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<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-09-02" version="114" xmlns="http://uniprot.org/uniprot">
  <accession>Q7W1T9</accession>
  <name>ASPD1_BORPA</name>
  <protein>
    <recommendedName>
      <fullName evidence="1">L-aspartate dehydrogenase 1</fullName>
      <ecNumber evidence="1">1.4.1.21</ecNumber>
    </recommendedName>
  </protein>
  <gene>
    <name evidence="1" type="primary">nadX1</name>
    <name type="ordered locus">BPP0257</name>
  </gene>
  <organism>
    <name type="scientific">Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)</name>
    <dbReference type="NCBI Taxonomy" id="257311"/>
    <lineage>
      <taxon>Bacteria</taxon>
      <taxon>Pseudomonadati</taxon>
      <taxon>Pseudomonadota</taxon>
      <taxon>Betaproteobacteria</taxon>
      <taxon>Burkholderiales</taxon>
      <taxon>Alcaligenaceae</taxon>
      <taxon>Bordetella</taxon>
    </lineage>
  </organism>
  <reference key="1">
    <citation type="journal article" date="2003" name="Nat. Genet." volume="35" first="32" last="40">
      <title>Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.</title>
      <authorList>
        <person name="Parkhill J."/>
        <person name="Sebaihia M."/>
        <person name="Preston A."/>
        <person name="Murphy L.D."/>
        <person name="Thomson N.R."/>
        <person name="Harris D.E."/>
        <person name="Holden M.T.G."/>
        <person name="Churcher C.M."/>
        <person name="Bentley S.D."/>
        <person name="Mungall K.L."/>
        <person name="Cerdeno-Tarraga A.-M."/>
        <person name="Temple L."/>
        <person name="James K.D."/>
        <person name="Harris B."/>
        <person name="Quail M.A."/>
        <person name="Achtman M."/>
        <person name="Atkin R."/>
        <person name="Baker S."/>
        <person name="Basham D."/>
        <person name="Bason N."/>
        <person name="Cherevach I."/>
        <person name="Chillingworth T."/>
        <person name="Collins M."/>
        <person name="Cronin A."/>
        <person name="Davis P."/>
        <person name="Doggett J."/>
        <person name="Feltwell T."/>
        <person name="Goble A."/>
        <person name="Hamlin N."/>
        <person name="Hauser H."/>
        <person name="Holroyd S."/>
        <person name="Jagels K."/>
        <person name="Leather S."/>
        <person name="Moule S."/>
        <person name="Norberczak H."/>
        <person name="O'Neil S."/>
        <person name="Ormond D."/>
        <person name="Price C."/>
        <person name="Rabbinowitsch E."/>
        <person name="Rutter S."/>
        <person name="Sanders M."/>
        <person name="Saunders D."/>
        <person name="Seeger K."/>
        <person name="Sharp S."/>
        <person name="Simmonds M."/>
        <person name="Skelton J."/>
        <person name="Squares R."/>
        <person name="Squares S."/>
        <person name="Stevens K."/>
        <person name="Unwin L."/>
        <person name="Whitehead S."/>
        <person name="Barrell B.G."/>
        <person name="Maskell D.J."/>
      </authorList>
      <dbReference type="PubMed" id="12910271"/>
      <dbReference type="DOI" id="10.1038/ng1227"/>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain>12822 / ATCC BAA-587 / NCTC 13253</strain>
    </source>
  </reference>
  <comment type="function">
    <text evidence="1">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="1">
      <text>L-aspartate + NADP(+) + H2O = oxaloacetate + NH4(+) + NADPH + H(+)</text>
      <dbReference type="Rhea" id="RHEA:11784"/>
      <dbReference type="ChEBI" id="CHEBI:15377"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:16452"/>
      <dbReference type="ChEBI" id="CHEBI:28938"/>
      <dbReference type="ChEBI" id="CHEBI:29991"/>
      <dbReference type="ChEBI" id="CHEBI:57783"/>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
      <dbReference type="EC" id="1.4.1.21"/>
    </reaction>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="1">
      <text>L-aspartate + NAD(+) + H2O = oxaloacetate + NH4(+) + NADH + H(+)</text>
      <dbReference type="Rhea" id="RHEA:11788"/>
      <dbReference type="ChEBI" id="CHEBI:15377"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:16452"/>
      <dbReference type="ChEBI" id="CHEBI:28938"/>
      <dbReference type="ChEBI" id="CHEBI:29991"/>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
      <dbReference type="ChEBI" id="CHEBI:57945"/>
      <dbReference type="EC" id="1.4.1.21"/>
    </reaction>
  </comment>
  <comment type="pathway">
    <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
  </comment>
  <comment type="miscellaneous">
    <text evidence="1">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
  </comment>
  <comment type="similarity">
    <text evidence="1">Belongs to the L-aspartate dehydrogenase family.</text>
  </comment>
  <comment type="sequence caution" evidence="2">
    <conflict type="erroneous initiation">
      <sequence resource="EMBL-CDS" id="CAE39998" version="1"/>
    </conflict>
  </comment>
  <dbReference type="EC" id="1.4.1.21" evidence="1"/>
  <dbReference type="EMBL" id="BX640423">
    <property type="protein sequence ID" value="CAE39998.1"/>
    <property type="status" value="ALT_INIT"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="WP_003818490.1">
    <property type="nucleotide sequence ID" value="NC_002928.3"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q7W1T9"/>
  <dbReference type="SMR" id="Q7W1T9"/>
  <dbReference type="GeneID" id="93206488"/>
  <dbReference type="KEGG" id="bpa:BPP0257"/>
  <dbReference type="HOGENOM" id="CLU_089550_0_0_4"/>
  <dbReference type="UniPathway" id="UPA00253">
    <property type="reaction ID" value="UER00456"/>
  </dbReference>
  <dbReference type="GO" id="GO:0033735">
    <property type="term" value="F:L-aspartate dehydrogenase [NAD(P)+] activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-EC"/>
  </dbReference>
  <dbReference type="GO" id="GO:0051287">
    <property type="term" value="F:NAD binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="GO" id="GO:0050661">
    <property type="term" value="F:NADP binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="GO" id="GO:0009435">
    <property type="term" value="P:NAD+ biosynthetic process"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.30.360.10">
    <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.40.50.720">
    <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="HAMAP" id="MF_01265">
    <property type="entry name" value="NadX"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR005106">
    <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR002811">
    <property type="entry name" value="Asp_DH"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR020626">
    <property type="entry name" value="Asp_DH_prok"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR011182">
    <property type="entry name" value="L-Asp_DH"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR036291">
    <property type="entry name" value="NAD(P)-bd_dom_sf"/>
  </dbReference>
  <dbReference type="NCBIfam" id="NF009828">
    <property type="entry name" value="PRK13303.1-3"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="NCBIfam" id="NF009829">
    <property type="entry name" value="PRK13303.1-4"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR31873:SF6">
    <property type="entry name" value="ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR31873">
    <property type="entry name" value="L-ASPARTATE DEHYDROGENASE-RELATED"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF01958">
    <property type="entry name" value="Asp_DH_C"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF03447">
    <property type="entry name" value="NAD_binding_3"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PIRSF" id="PIRSF005227">
    <property type="entry name" value="Asp_dh_NAD_syn"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF55347">
    <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF51735">
    <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="inferred from homology"/>
  <keyword id="KW-0520">NAD</keyword>
  <keyword id="KW-0521">NADP</keyword>
  <keyword id="KW-0560">Oxidoreductase</keyword>
  <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
  <feature type="chain" id="PRO_0000144883" description="L-aspartate dehydrogenase 1">
    <location>
      <begin position="1"/>
      <end position="258"/>
    </location>
  </feature>
  <feature type="active site" evidence="1">
    <location>
      <position position="211"/>
    </location>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="121"/>
    </location>
    <ligand>
      <name>NAD(+)</name>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
    </ligand>
  </feature>
  <feature type="binding site" evidence="1">
    <location>
      <position position="181"/>
    </location>
    <ligand>
      <name>NAD(+)</name>
      <dbReference type="ChEBI" id="CHEBI:57540"/>
    </ligand>
  </feature>
  <evidence type="ECO:0000255" key="1">
    <source>
      <dbReference type="HAMAP-Rule" id="MF_01265"/>
    </source>
  </evidence>
  <evidence type="ECO:0000305" key="2"/>
  <sequence length="258" mass="26302" checksum="185F7E1B0C222E44" modified="2005-08-16" version="2">MNTPLRVGIVGCGVLANAMAGHLARQPRPVEIVGCLVRDPGRARGALPCHGSWEALLAQRPEVVVECAGQAALAQYAQAILAAGVDLVPASVGALADDALRGALLEAAAAAGARIRIPSGAMVGIDGLAAARHVGVAEVLYRGTMPPVALQRYVSGPLPERGLAFAGSAREAVARFPKNANLTGTIALAGIGFDRTRVEMLIDPDATANVHELLARGEFGDFHARVSGLRISESSPSSRIVAGSLAQAALGSGFLALS</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>