ID   Q7PSL0_ANOGA            Unreviewed;       374 AA.
AC   Q7PSL0;
DT   15-DEC-2003, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 5.
DT   02-SEP-2026, entry version 124.
DE   RecName: Full=Luciferin 4-monooxygenase {ECO:0000256|ARBA:ARBA00019043};
DE            EC=1.13.12.7 {ECO:0000256|ARBA:ARBA00012532};
GN   Name=1270951 {ECO:0000313|EnsemblMetazoa:AGAP003481-PA};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida;
OC   Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota;
OC   Aparaglossata; Panorpida; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165 {ECO:0000313|EnsemblMetazoa:AGAP003481-PA, ECO:0000313|Proteomes:UP000007062};
RN   [1] {ECO:0000313|EnsemblMetazoa:AGAP003481-PA, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP003481-PA,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M., Wides R.,
RA   Salzberg S.L., Loftus B., Yandell M., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A., Liang Y., Lin J.J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z., Unger M.F., Walenz B., Wang A.,
RA   Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A.,
RA   Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2] {ECO:0000313|EnsemblMetazoa:AGAP003481-PA, ECO:0000313|Proteomes:UP000007062}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP003481-PA,
RC   ECO:0000313|Proteomes:UP000007062};
RX   PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA   Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT   "The Anopheles gambiae genome: an update.";
RL   Trends Parasitol. 20:49-52(2004).
RN   [3] {ECO:0000313|EnsemblMetazoa:AGAP003481-PA}
RP   IDENTIFICATION.
RC   STRAIN=PEST {ECO:0000313|EnsemblMetazoa:AGAP003481-PA};
RG   EnsemblMetazoa;
RL   Submitted (JAN-2021) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu +
CC         AMP + CO2 + diphosphate; Xref=Rhea:RHEA:10732, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16792, ChEBI:CHEBI:30212,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58038,
CC         ChEBI:CHEBI:456215; EC=1.13.12.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00048497};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; AAAB01008820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q7PSL0; -.
DR   STRING; 7165.Q7PSL0; -.
DR   PaxDb; 7165-Q7PSL0; -.
DR   EnsemblMetazoa; AGAP003481-RA; AGAP003481-PA; AGAP003481.
DR   KEGG; aga:1270951; -.
DR   VEuPathDB; VectorBase:AGAMI1_001200; -.
DR   VEuPathDB; VectorBase:AGAP003481; -.
DR   eggNOG; KOG1176; Eukaryota.
DR   HOGENOM; CLU_000022_59_4_1; -.
DR   OMA; YETEGCK; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 2.30.38.10; Luciferase, Domain 3; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_synth/lig_dom.
DR   PANTHER; PTHR24096:SF423; GM05240P; 1.
DR   PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Luminescence {ECO:0000256|ARBA:ARBA00023223};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Photoprotein {ECO:0000256|ARBA:ARBA00023262};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007062}.
FT   DOMAIN          49..370
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   374 AA;  40934 MW;  D23C21C2A0144FCA CRC64;
     MHTKEDDQFV LYGGPDPTDL DRYGSLGEVI VAELKLRPAN IGLIDPVTLE ELSYSQILER
     SARLAIGLAK LGIKRTDNVA IFSQNSLEYC ITMFGSIFVG APLALLNPAY VEGELRHAIG
     LANPKLIFIS PDVLQKLMHT LRGIQGPKPR VVLCGEHPDA RQYPELIPFA SLLDNAPLDV
     NVYRPEPVNK AGQVALIVLS SGTTGLPKGV ELTHQSIIAT IAHSKESAKL LELPDQLVAL
     AVTPLFHVVA GVGLLNMVTN NCRCVVMPRF DPHLFLSCIE KYRVNLMTLV PPLMVFLAKH
     PMVDNYDLSS LMTLFCGAAP LSKEIEDQVR ERLGVAFIRQ GYGMSETTLG VLMQDGFENK
     AGSVGKVRMG QWVK
//