ID Q7PL26_DROME Unreviewed; 226 AA. AC Q7PL26; DT 15-DEC-2003, integrated into UniProtKB/TrEMBL. DT 15-JAN-2008, sequence version 2. DT 02-SEP-2026, entry version 164. DE RecName: Full=Repressor of RNA polymerase III transcription MAF1 {ECO:0000256|PIRNR:PIRNR037240}; GN Name=Maf1 {ECO:0000313|EMBL:EAA46257.2, GN ECO:0000313|FlyBase:FBgn0267861}; GN Synonyms=CR41604 {ECO:0000313|EMBL:EAA46257.2}, dMaf1 GN {ECO:0000313|EMBL:EAA46257.2}, Dmel\CG40196 GN {ECO:0000313|EMBL:EAA46257.2}, Maf {ECO:0000313|EMBL:EAA46257.2}, maf1 GN {ECO:0000313|EMBL:EAA46257.2}; GN ORFNames=CG40196 {ECO:0000313|EMBL:EAA46257.2, GN ECO:0000313|FlyBase:FBgn0267861}, Dmel_CG40196 GN {ECO:0000313|EMBL:EAA46257.2}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Altocrustacea; Allotriocarida; OC Hexapoda; Insecta; Pterygota; Neoptera; Eumetabola; Endopterygota; OC Aparaglossata; Panorpida; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [5] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:EAA46257.2} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [9] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [10] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [11] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [12] {ECO:0000313|EMBL:EAA46257.2, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [13] {ECO:0000313|EMBL:EAA46257.2} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (DEC-2023) to the EMBL/GenBank/DDBJ databases. RN [14] {ECO:0000313|EMBL:EAA46257.2} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2025) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Element of the TORC1 signaling pathway that acts as a CC mediator of diverse signals and that represses RNA polymerase III CC transcription. Inhibits the de novo assembly of TFIIIB onto DNA. CC {ECO:0000256|PIRNR:PIRNR037240}. CC -!- INTERACTION: CC Q7PL26; Q9VEL2: Brf; NbExp=2; IntAct=EBI-7766765, EBI-3412060; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR037240}. CC -!- SIMILARITY: Belongs to the MAF1 family. {ECO:0000256|ARBA:ARBA00006231, CC ECO:0000256|PIRNR:PIRNR037240}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE013599; EAA46257.2; -; Genomic_DNA. DR EMBL; AE013599; EAA46258.2; -; Genomic_DNA. DR EMBL; AE013599; EDP27993.1; -; Genomic_DNA. DR EMBL; AE013599; EFA98710.1; -; Genomic_DNA. DR EMBL; AE013599; EYR77331.1; -; Genomic_DNA. DR RefSeq; NP_001015167.2; NM_001015167.3. DR RefSeq; NP_001015168.2; NM_001015168.4. DR RefSeq; NP_001104014.1; NM_001110544.3. DR RefSeq; NP_001163882.1; NM_001170411.1. DR RefSeq; NP_001287649.1; NM_001300720.1. DR AlphaFoldDB; Q7PL26; -. DR SMR; Q7PL26; -. DR IntAct; Q7PL26; 1. DR STRING; 7227.FBpp0112553; -. DR PaxDb; 7227-FBpp0112553; -. DR PeptideAtlas; Q7PL26; -. DR GeneID; 3354925; -. DR KEGG; dme:Dmel_CG40196; -. DR UCSC; CG40196-RA; d. melanogaster. DR AGR; FB:FBgn0267861; -. DR CTD; 84232; -. DR FlyBase; FBgn0267861; Maf1. DR VEuPathDB; VectorBase:FBgn0267861; -. DR eggNOG; KOG3104; Eukaryota. DR HOGENOM; CLU_037043_3_1_1; -. DR OMA; CKMAGDH; -. DR OrthoDB; 277029at2759; -. DR Reactome; R-DME-8943724; Regulation of PTEN gene transcription. DR BioGRID-ORCS; 3354925; 1 hit in 1 CRISPR screen. DR Proteomes; UP000000803; Chromosome 2R. DR Bgee; FBgn0267861; Expressed in distal medullary amacrine neuron Dm11 in insect head and 261 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000994; F:RNA polymerase III core binding; IBA:GO_Central. DR GO; GO:0016480; P:negative regulation of transcription by RNA polymerase III; IMP:FlyBase. DR FunFam; 3.40.1000.50:FF:000003; Repressor of RNA polymerase III transcription MAF1; 1. DR Gene3D; 3.40.1000.50; Repressor of RNA polymerase III transcription Maf1; 1. DR InterPro; IPR015257; Maf1. DR InterPro; IPR038564; Maf1_sf. DR PANTHER; PTHR22504; REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1; 1. DR PANTHER; PTHR22504:SF0; REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG; 1. DR Pfam; PF09174; Maf1; 1. DR PIRSF; PIRSF037240; RNA_polIII_Trep_MAF1; 1. PE 1: Evidence at protein level; KW Nucleus {ECO:0000256|PIRNR:PIRNR037240}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Repressor {ECO:0000256|PIRNR:PIRNR037240}; KW Transcription {ECO:0000256|PIRNR:PIRNR037240}; KW Transcription regulation {ECO:0000256|PIRNR:PIRNR037240}. SQ SEQUENCE 226 AA; 25655 MW; 63906EFF1748CE12 CRC64; MKLLESSRFE AINNALSIQT SGITIFGRIE SYSCKMVAAE KVLYKRFTAD SHGHDLQALS PPQTLADFSP NFRRNNSQSG DEGITLCDTI SRKTLFYLIA TLNASFEPDY DFSEAKSHEF SKEPSLQWVM NSIHANLSAL AGDKYQAIRQ PLWSAVDDEV ILSECDIYSY NPDLSCDPFG EPGCLWSFNY FFYNKKLKRI VFFTSRAVNS LYAGETLPFS MEEEVY //