Q7N4T9 Q7N4T9_PHOLL ATP-dependent dethiobiotin synthetase BioD 6.3.3.3 DTB synthetase DTBS Dethiobiotin synthase bioD plu2227 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) Photorhabdus luminescens subsp. laumondii Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Enterobacterales Morganellaceae Photorhabdus NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] DSM 15139 / CIP 105565 / TT01 Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring. (7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H(+) Mg(2+) Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2. Homodimer. Cytoplasm Belongs to the dethiobiotin synthetase family. Lacks conserved residue(s) required for the propagation of feature annotation. ATP-binding Biotin biosynthesis Cytoplasm Ligase Magnesium Metal-binding Nucleotide-binding Reference proteome ATP Mg(2+) substrate ATP Mg(2+) ATP Mg(2+) ATP ATP MLTRLFVTGTDTNIGKTIVTRALLQAFNRDGATAVGYKPIATEGYETEEGMRNRDGVILQKSSPVPLKYEEINPVIWKNSYCEGNQVDFEQMKKGLNNLSNKADRVIIEGNGGWRVLLDDETFYFDWVIQEKIPVILVVGIQPGCVNHSILTAQAIINDGLQLVGWVANRINPGLSHYTKVMDRLRRHINAPQLGEIPYILRPEEKDLSCYLDVATIFKQVGGSESEVGIESQYT Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License