ID   PG044_VACCA             Reviewed;         149 AA.
AC   Q76ZX2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-SEP-2026, entry version 64.
DE   RecName: Full=Protein K7;
GN   Name=OPG044; OrderedLocusNames=MVA028R, ACAM3000_MVA_028;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Virulence factor that affects the acute immune response to
CC       infection. Bcl-2-like protein which, through its interaction with the
CC       DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated
CC       IRF3 activation. Contributes to virulence by binding to the host TRAF6
CC       and IRAK2 and preventing host NF-kappa-B activation.
CC       {ECO:0000250|UniProtKB:P68466}.
CC   -!- SUBUNIT: Interacts with DDX3; this interaction inhibits DDX3 and
CC       suppresses DDX3-mediated IFN-beta promoter induction. Interacts with
CC       TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB
CC       activation. {ECO:0000250|UniProtKB:P68466}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250|UniProtKB:P68466}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC       {ECO:0000250|UniProtKB:P68466}.
CC   -!- SIMILARITY: Belongs to the orthopoxvirus OPG044 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U94848; AAB96484.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10426.1; -; Genomic_DNA.
DR   RefSeq; YP_232921.1; NC_006998.1.
DR   BMRB; Q76ZX2; -.
DR   SMR; Q76ZX2; -.
DR   DNASU; 3707496; -.
DR   GeneID; 3707496; -.
DR   KEGG; vg:3707496; -.
DR   GO; GO:0030430; C:host cell cytoplasm; ISS:UniProtKB.
DR   GO; GO:0052170; P:symbiont-mediated suppression of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.437.20; dsDNA poxvirus; 1.
DR   InterPro; IPR009174; Orthopox_K7.
DR   InterPro; IPR022819; Poxvirus_Bcl-2-like.
DR   InterPro; IPR043018; Poxvirus_sf.
DR   Pfam; PF06227; Poxv_Bcl-2-like; 1.
DR   PIRSF; PIRSF003764; VAC_K7R; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host RLR pathway by virus; Viral immunoevasion.
FT   CHAIN           1..149
FT                   /note="Protein K7"
FT                   /id="PRO_0000099607"
SQ   SEQUENCE   149 AA;  17468 MW;  B3E972A93DF97DC8 CRC64;
     MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC GRLYKELMKF
     DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA TIGICAKITE HWGYKKISES
     RFQSLGNITD LMTDDNINIL ILFLEKKLN
//