ID   Q74CL9_GEOSL            Unreviewed;       349 AA.
AC   Q74CL9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   28-JAN-2026, entry version 132.
DE   SubName: Full=Response receiver-modulated cyclic diguanylate phosphodiesterase {ECO:0000313|EMBL:AAR35028.1};
GN   OrderedLocusNames=GSU1654 {ECO:0000313|EMBL:AAR35028.1};
OS   Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC   Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfuromonadia;
OC   Geobacterales; Geobacteraceae; Geobacter.
OX   NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR35028.1, ECO:0000313|Proteomes:UP000000577};
RN   [1] {ECO:0000313|EMBL:AAR35028.1, ECO:0000313|Proteomes:UP000000577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA
RC   {ECO:0000313|Proteomes:UP000000577};
RX   PubMed=14671304; DOI=10.1126/science.1088727;
RA   Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA   Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA   Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA   Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA   Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA   Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA   Fraser C.M.;
RT   "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT   environments.";
RL   Science 302:1967-1969(2003).
RN   [2] {ECO:0000313|EMBL:AAR35028.1, ECO:0000313|Proteomes:UP000000577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51573 / DSM 12127 / PCA
RC   {ECO:0000313|Proteomes:UP000000577};
RX   PubMed=22967216; DOI=10.1186/1471-2164-13-471;
RA   Butler J.E., Young N.D., Aklujkar M., Lovley D.R.;
RT   "Comparative genomic analysis of Geobacter sulfurreducens KN400, a strain
RT   with enhanced capacity for extracellular electron transfer and electricity
RT   production.";
RL   BMC Genomics 13:471-471(2012).
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DR   EMBL; AE017180; AAR35028.1; -; Genomic_DNA.
DR   RefSeq; WP_010942298.1; NC_002939.5.
DR   AlphaFoldDB; Q74CL9; -.
DR   SMR; Q74CL9; -.
DR   STRING; 243231.GSU1654; -.
DR   EnsemblBacteria; AAR35028; AAR35028; GSU1654.
DR   KEGG; gsu:GSU1654; -.
DR   PATRIC; fig|243231.5.peg.1695; -.
DR   eggNOG; COG3437; Bacteria.
DR   HOGENOM; CLU_000445_92_10_7; -.
DR   InParanoid; Q74CL9; -.
DR   OrthoDB; 9776250at2; -.
DR   Proteomes; UP000000577; Chromosome.
DR   GO; GO:0004112; F:cyclic-nucleotide phosphodiesterase activity; IBA:GO_Central.
DR   GO; GO:0009214; P:cyclic nucleotide catabolic process; IBA:GO_Central.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR052020; Cyclic_di-GMP/3'3'-cGAMP_PDE.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR45228; CYCLIC DI-GMP PHOSPHODIESTERASE TM_0186-RELATED; 1.
DR   PANTHER; PTHR45228:SF5; CYCLIC DI-GMP PHOSPHODIESTERASE VC_1348-RELATED; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00471; HDc; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF52172; CheY-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   4: Predicted;
KW   Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000577}.
FT   DOMAIN          4..118
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000259|PROSITE:PS50110"
FT   DOMAIN          152..347
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   349 AA;  39136 MW;  ACF757A2724ED985 CRC64;
     MKATILTVDD EEMIRDLLVT ALSREGYDCF QAGSADEARD VLLNNRVELA LLDIMMPGTS
     GVDLLKEIKK ISADTVVLMV TAISDMETAM RCIHLGADDY ILKPFDIERV LLTIKNSLEK
     QRLLIENREY QANLEKKVLE QTGQIRSAME ELNLTYDHTL TTLVRALDAR EKETGSHSER
     VMNYTILLAE TMGIRAAEVA IMARGALLHD IGKIGVSDNI LLKPAKLDEV EWRHMKQHPQ
     MGYDILSGIK FLKAPAEVVY AHHERYDGTG YPKGLRGSEI PLGARIFSLV DTLDAMTSDR
     PYRRALPFSA VLAEVERCIG SQFDPSIAAT FLSIPKDKWE KAGKRLFLD
//