ID   COX4_MYCPA              Reviewed;         139 AA.
AC   Q73YL6;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   04-NOV-2026, entry version 104.
DE   RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 4;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
GN   Name=ctaF; OrderedLocusNames=MAP_1939c;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Mycobacteriaceae; Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-
CC         [cytochrome c] + 2 H2O + 4 H(+)(out); Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC       family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS04256.1; -; Genomic_DNA.
DR   RefSeq; WP_003872269.1; NC_002944.2.
DR   SMR; Q73YL6; -.
DR   STRING; 262316.MAP_1939c; -.
DR   GeneID; 75269842; -.
DR   KEGG; mpa:MAP_1939c; -.
DR   eggNOG; ENOG5032TTI; Bacteria.
DR   HOGENOM; CLU_145919_0_0_11; -.
DR   OMA; AALYVYW; -.
DR   InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR   Pfam; PF12270; Cyt_c_ox_IV; 1.
DR   PIRSF; PIRSF017385; CtaF; 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0022900; P:electron transport chain; IEA:InterPro.
DR   AlphaFoldDB; Q73YL6; -.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Translocase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..139
FT                   /note="Probable cytochrome c oxidase polypeptide 4"
FT                   /id="PRO_0000220018"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  15076 MW;  982FDD33F94C2CBA CRC64;
     MHIEARLFEF IAGFFFLTAL LYGVLTALFA TGGEEWAGTT ALALTGGLAL IVATFFRFVA
     RRIDTRPEDY EGAEISDGAG ELGFFSPHSW WPILIALSGS VAAVGIALWL PWLIVAGVMF
     ILSSVAGLVF EYYLGPEKH
//