ID   ZN852_HUMAN             Reviewed;         543 AA.
AC   Q6ZMS4; B4DLD7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 4.
DT   02-SEP-2026, entry version 156.
DE   RecName: Full=Zinc finger protein 852;
GN   Name=ZNF852;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tongue;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAG59499.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK296954; BAG59499.1; ALT_FRAME; mRNA.
DR   EMBL; AC099669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001274278.1; NM_001287349.3.
DR   RefSeq; NP_001410398.1; NM_001423469.1.
DR   AlphaFoldDB; Q6ZMS4; -.
DR   SMR; Q6ZMS4; -.
DR   BioGRID; 130087; 10.
DR   FunCoup; Q6ZMS4; 95.
DR   IntAct; Q6ZMS4; 8.
DR   STRING; 9606.ENSP00000389841; -.
DR   iPTMnet; Q6ZMS4; -.
DR   PhosphoSitePlus; Q6ZMS4; -.
DR   BioMuta; ZNF852; -.
DR   DMDM; 298286894; -.
DR   jPOST; Q6ZMS4; -.
DR   MassIVE; Q6ZMS4; -.
DR   PaxDb; 9606-ENSP00000389841; -.
DR   PeptideAtlas; Q6ZMS4; -.
DR   ProteomicsDB; 67908; -.
DR   Pumba; Q6ZMS4; -.
DR   Antibodypedia; 62713; 23 antibodies from 5 providers.
DR   DNASU; 285346; -.
DR   Ensembl; ENST00000436261.7; ENSP00000389841.2; ENSG00000178917.19.
DR   GeneID; 285346; -.
DR   KEGG; hsa:285346; -.
DR   UCSC; uc062iux.1; human.
DR   AGR; HGNC:27713; -.
DR   CTD; 285346; -.
DR   DisGeNET; 285346; -.
DR   GeneCards; ZNF852; -.
DR   HGNC; HGNC:27713; ZNF852.
DR   HPA; ENSG00000178917; Low tissue specificity.
DR   OpenTargets; ENSG00000178917; -.
DR   VEuPathDB; HostDB:ENSG00000178917; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000165221; -.
DR   HOGENOM; CLU_002678_44_5_1; -.
DR   InParanoid; Q6ZMS4; -.
DR   OMA; HHLKAWF; -.
DR   OrthoDB; 9411774at2759; -.
DR   PAN-GO; Q6ZMS4; 4 GO annotations based on evolutionary models.
DR   PhylomeDB; Q6ZMS4; -.
DR   PathwayCommons; Q6ZMS4; -.
DR   SignaLink; Q6ZMS4; -.
DR   Agora; ENSG00000178917; -.
DR   BioGRID-ORCS; 285346; 5 hits in 326 CRISPR screens.
DR   GenomeRNAi; 285346; -.
DR   Pharos; Q6ZMS4; Tdark.
DR   PRO; PR:Q6ZMS4; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q6ZMS4; protein.
DR   Bgee; ENSG00000178917; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 110 other cell types or tissues.
DR   ExpressionAtlas; Q6ZMS4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   FunFam; 3.30.160.60:FF:000250; zinc finger protein 197 isoform X1; 1.
DR   FunFam; 3.30.160.60:FF:000512; zinc finger protein 197 isoform X1; 1.
DR   FunFam; 3.30.160.60:FF:002343; Zinc finger protein 33A; 1.
DR   FunFam; 3.30.160.60:FF:000016; zinc finger protein 37 homolog; 1.
DR   FunFam; 3.30.160.60:FF:002090; Zinc finger protein 473; 1.
DR   FunFam; 3.30.160.60:FF:002254; Zinc finger protein 540; 1.
DR   FunFam; 3.30.160.60:FF:000878; Zinc finger protein 544; 1.
DR   FunFam; 3.30.160.60:FF:001090; zinc finger protein 629 isoform X2; 1.
DR   FunFam; 3.30.160.60:FF:000785; zinc finger protein 648; 1.
DR   FunFam; 3.30.160.60:FF:000459; Zinc finger with KRAB and SCAN domains 1; 2.
DR   FunFam; 3.30.160.60:FF:000537; Zinc finger with KRAB and SCAN domains 7; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR050758; Znf_C2H2-type.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23234:SF8; C2H2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR23234; ZNF44 PROTEIN; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 12.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   1: Evidence at protein level;
KW   Metal-binding; Nucleus; Phosphoprotein; Proteomics identification;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..543
FT                   /note="Zinc finger protein 852"
FT                   /id="PRO_0000332125"
FT   DOMAIN          8..82
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         159..181
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         187..209
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         215..237
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         243..265
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         271..293
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         299..321
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         327..349
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         355..377
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         383..405
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         411..433
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         439..461
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         467..489
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOD_RES         145
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   CONFLICT        158
FT                   /note="S -> P (in Ref. 1; BAG59499)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   543 AA;  62084 MW;  4DE82359226B9414 CRC64;
     MVRPQDTVAY EDLSEDYTQK KWKGLALSQR ALHWNMMLEN DRSMASLGRN MMESSELTPK
     QEIFKGSESS NSTSGGLFGV VPGGTETGDV CEDTFKELEG QPSNEEGSRL ESDFLEIIDE
     DKKKSTKDRY EEYKEVEEHP PLSSSPVEHE GVLKGQKSYR CDECGKAFYW SSHLIGHRRI
     HTGEKPYECN ECGKTFRQTS QLIVHLRTHT GEKPYECSEC GKAYRHSSHL IQHQRLHNGE
     KPYKCNECAK AFNQSSKLFD HQRTHTGEKP YECKECGAAF SRSKNLVRHQ FLHTGKKPYK
     CNECGRAFCS NRNLIDHQRT HTGEKPYKCN ECGKAFSRSK CLIRHQSLHT GEKPYKCSEC
     GKAFNQISQL VEHERIHTGE KPFKCSECGK AFGLSKCLIR HQRLHTSEKP YKCNECGKSF
     NQNSYLIIHQ RIHTGEKPYE CNECGKVFSY NSSLMVHQRT HTGEKPYKCN SCGKAFSDSS
     QLTVHQRVHT GEKNLMNVLS VGKPLVSVPL LITTSELMLE RSPQVWLGHL LKAWFSETDS
     KDL
//