ID   XKR5_HUMAN              Reviewed;         686 AA.
AC   Q6UX68; A0A087X143; A0A096LPC1; Q5GH74;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   02-SEP-2026, entry version 138.
DE   RecName: Full=XK-related protein 5 {ECO:0000305};
GN   Name=XKR5 {ECO:0000312|HGNC:HGNC:20782};
GN   Synonyms=XRG5 {ECO:0000303|Ref.1};
GN   ORFNames=UNQ2754/PRO6493 {ECO:0000303|PubMed:12975309};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH66};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=5a {ECO:0000303|Ref.1};
CC         IsoId=Q6UX68-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6UX68-3; Sequence=VSP_059371, VSP_059372;
CC   -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC       premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC       decay. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAT07092.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR   EMBL; AY534242; AAT07091.1; -; mRNA.
DR   EMBL; AY534243; AAT07092.1; ALT_SEQ; mRNA.
DR   EMBL; AY358489; AAQ88853.1; -; mRNA.
DR   EMBL; AF233439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471153; EAW80480.1; -; Genomic_DNA.
DR   CCDS; CCDS47763.2; -. [Q6UX68-1]
DR   RefSeq; NP_001276902.1; NM_001289973.2.
DR   RefSeq; NP_997294.3; NM_207411.5. [Q6UX68-1]
DR   AlphaFoldDB; Q6UX68; -.
DR   SMR; Q6UX68; -.
DR   BioGRID; 133187; 1.
DR   FunCoup; Q6UX68; 507.
DR   IntAct; Q6UX68; 1.
DR   STRING; 9606.ENSP00000483879; -.
DR   TCDB; 2.A.112.1.14; the kx blood-group antigen (kxa) family.
DR   GlyGen; Q6UX68; 5 sites, 1 O-linked glycan (4 sites).
DR   iPTMnet; Q6UX68; -.
DR   PhosphoSitePlus; Q6UX68; -.
DR   BioMuta; XKR5; -.
DR   DMDM; 74738183; -.
DR   MassIVE; Q6UX68; -.
DR   PaxDb; 9606-ENSP00000483879; -.
DR   PeptideAtlas; Q6UX68; -.
DR   ProteomicsDB; 67569; -. [Q6UX68-1]
DR   Antibodypedia; 74670; 8 antibodies from 4 providers.
DR   DNASU; 389610; -.
DR   Ensembl; ENST00000618742.3; ENSP00000483879.1; ENSG00000275591.6. [Q6UX68-1]
DR   Ensembl; ENST00000618990.4; ENSP00000485506.1; ENSG00000275591.6. [Q6UX68-3]
DR   GeneID; 389610; -.
DR   KEGG; hsa:389610; -.
DR   MANE-Select; ENST00000618742.3; ENSP00000483879.1; NM_207411.5; NP_997294.3.
DR   UCSC; uc033baq.2; human.
DR   AGR; HGNC:20782; -.
DR   ClinPGx; PA142670564; -.
DR   CTD; 389610; -.
DR   GeneCards; XKR5; -.
DR   HGNC; HGNC:20782; XKR5.
DR   HPA; ENSG00000275591; Not detected.
DR   MIM; 621391; gene.
DR   OpenTargets; ENSG00000275591; -.
DR   VEuPathDB; HostDB:ENSG00000275591; -.
DR   eggNOG; KOG4790; Eukaryota.
DR   GeneTree; ENSGT01140000282533; -.
DR   InParanoid; Q6UX68; -.
DR   OMA; VDSTCHW; -.
DR   OrthoDB; 6348184at2759; -.
DR   PAN-GO; Q6UX68; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; Q6UX68; -.
DR   PathwayCommons; Q6UX68; -.
DR   SignaLink; Q6UX68; -.
DR   Agora; ENSG00000275591; -.
DR   BioGRID-ORCS; 389610; 0 hits in 183 CRISPR screens.
DR   GenomeRNAi; 389610; -.
DR   Pharos; Q6UX68; Tdark.
DR   PRO; PR:Q6UX68; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q6UX68; protein.
DR   Bgee; ENSG00000275591; Expressed in stromal cell of endometrium and 20 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR018629; XK-rel.
DR   InterPro; IPR050895; XK-related_scramblase.
DR   PANTHER; PTHR16024; XK-RELATED PROTEIN; 1.
DR   PANTHER; PTHR16024:SF15; XK-RELATED PROTEIN 5; 1.
DR   Pfam; PF09815; XK-related; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Membrane; Proteomics identification;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..686
FT                   /note="XK-related protein 5"
FT                   /id="PRO_0000190782"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          339..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..509
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..536
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..567
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         82..86
FT                   /note="HWDAA -> PQIHL (in isoform 2)"
FT                   /id="VSP_059371"
FT   VAR_SEQ         87..686
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_059372"
FT   CONFLICT        69
FT                   /note="M -> V (in Ref. 1; AAT07091 and 2; AAQ88853)"
SQ   SEQUENCE   686 AA;  75014 MW;  DD0B46DA37F27F57 CRC64;
     MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ ALSYLWFRAD
     GHPGHCSLMM LHLLQLGVWK RHWDAALTSL QKELEAPHRG WLQLQEADLS ALRLLEALLQ
     TGPHLLLQTY VFLASDFTDI VPGVSTLFSW SSLSWALVSY TRFMGFMKPG HLAMPWAALF
     CQQLWRMGML GTRVLSLVLF YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF
     NLLVGAVYIL CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV
     LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA TDLAGKRTES
     SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL SHHHWLWVKL ALKTGNVSKI
     NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS AQQELPSSSR DPSTLENSSA FEGVPKAEAD
     PLETSSYVSF ASDQQDEAPT QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS
     TLYFSATAEV ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP
     ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ LRTAHEPCLT
     STPKSESIQT DCSCREQMKQ EPSFFI
//