ID Q6PJD6_HUMAN Unreviewed; 531 AA. AC Q6PJD6; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 08-OCT-2025, entry version 110. DE SubName: Full=DVL1 protein {ECO:0000313|EMBL:AAH17225.1}; DE Flags: Fragment; GN Name=DVL1 {ECO:0000313|EMBL:AAH17225.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH17225.1}; RN [1] {ECO:0000313|EMBL:AAH17225.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye {ECO:0000313|EMBL:AAH17225.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC017225; AAH17225.1; -; mRNA. DR AlphaFoldDB; Q6PJD6; -. DR PeptideAtlas; Q6PJD6; -. DR OrthoDB; 10031689at2759; -. DR ChiTaRS; DVL1; human. DR GO; GO:0005109; F:frizzled binding; IEA:UniProtKB-ARBA. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProtKB-ARBA. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:InterPro. DR CDD; cd04438; DEP_dishevelled; 1. DR CDD; cd06717; PDZ_Dishevelled-like; 1. DR FunFam; 1.10.10.10:FF:000040; segment polarity protein dishevelled homolog DVL-3; 1. DR FunFam; 2.30.42.10:FF:000014; Segment polarity protein dishevelled homolog DVL-3; 1. DR Gene3D; 2.30.42.10; -; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR000591; DEP_dom. DR InterPro; IPR024580; Dishevelled_C-dom. DR InterPro; IPR008339; Dishevelled_fam. DR InterPro; IPR003351; Dishevelled_protein_dom. DR InterPro; IPR015506; Dsh/Dvl-rel. DR InterPro; IPR001478; PDZ. DR InterPro; IPR036034; PDZ_sf. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1. DR PANTHER; PTHR10878:SF5; SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1-RELATED; 1. DR Pfam; PF00610; DEP; 1. DR Pfam; PF02377; Dishevelled; 1. DR Pfam; PF12316; Dsh_C; 1. DR Pfam; PF00595; PDZ; 1. DR PRINTS; PR01760; DISHEVELLED. DR PRINTS; PR01761; DISHEVELLED1. DR SMART; SM00049; DEP; 1. DR SMART; SM00228; PDZ; 1. DR SUPFAM; SSF50156; PDZ domain-like; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS50186; DEP; 1. DR PROSITE; PS50106; PDZ; 1. PE 2: Evidence at transcript level; FT DOMAIN 175..247 FT /note="PDZ" FT /evidence="ECO:0000259|PROSITE:PS50106" FT DOMAIN 324..398 FT /note="DEP" FT /evidence="ECO:0000259|PROSITE:PS50186" FT REGION 9..161 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 442..531 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 66..75 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 76..95 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 100..116 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 124..138 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 139..152 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 450..479 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAH17225.1" SQ SEQUENCE 531 AA; 57560 MW; BBAF00C1CD0FC781 CRC64; VVSWLVLAEG AHSDAGSQGT DSHTDLPPPL ERTGGIGDSR PPSFHPNVAS SRDGMDNETG TESMVSHRRE RARRRNREEA ARTNGHPRGD RRRDVGLPPD SASTALSSEL ESSSFVDSDE DGSTSRLSSS TEQSTSSRLI RKHKRRRRKQ RLRQADRASS FSSITDSTMS LNIVTVTLNM ERHHFLGISI VGQSNDRGDG GIYIGSIMKG GAVAADGRIE PGDMLLQVND VNFENMSNDD AVRVLREIVS QTGPISLTVA KCWDPTPRSY FTVPRADPVR PIDPAAWLSH TAALTGALPR YELEEAPLTV KSDMSAVVRV MQLPDSGLEI RDRMWLKITI ANAVIGADVV DWLYTHVEGF KERREARKYA SSLLKHGFLR HTVNKITFSE QCYYVFGDLC SNLATLNLNS GSSGTSDQDT LAPLPHPAAP WPLGQGYPYQ YPGPPPCFPP AYQDPGFSYG SGSTGSQQSE GSKSSGSTRS SRRAPGREKE RRAAGAGGSG SESDHTAPSG VGSSWRERPA GQLSRGSSPR S //