ID   Q6PH56_DANRE            Unreviewed;       643 AA.
AC   Q6PH56; A0A8M1PBC6;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   02-SEP-2026, entry version 164.
DE   RecName: Full=Heat shock cognate 71 kDa protein {ECO:0000256|ARBA:ARBA00040611};
GN   Name=hsp70.3 {ECO:0000313|ZFIN:ZDB-GENE-110713-1};
GN   Synonyms=hsp70 {ECO:0000313|EMBL:AAH56709.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH56709.1};
RN   [1] {ECO:0000313|EMBL:AAH56709.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH56709.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|ARBA:ARBA00007381, ECO:0000256|RuleBase:RU003322}.
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DR   EMBL; BC056709; AAH56709.1; -; mRNA.
DR   RefSeq; NP_571472.2; NM_131397.3.
DR   AlphaFoldDB; Q6PH56; -.
DR   SMR; Q6PH56; -.
DR   STRING; 7955.ENSDARP00000010413; -.
DR   PaxDb; 7955-ENSDARP00000010413; -.
DR   PeptideAtlas; Q6PH56; -.
DR   GeneID; 30671; -.
DR   KEGG; dre:30671; -.
DR   AGR; ZFIN:ZDB-GENE-110713-1; -.
DR   CTD; 30671; -.
DR   ZFIN; ZDB-GENE-110713-1; hsp70.3.
DR   eggNOG; KOG0101; Eukaryota.
DR   GeneTree; ENSGT00940000154813; -.
DR   HOGENOM; CLU_005965_3_0_1; -.
DR   OMA; CWTSARR; -.
DR   OrthoDB; 2401965at2759; -.
DR   Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-DRE-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR   Reactome; R-DRE-3371568; Attenuation phase.
DR   Reactome; R-DRE-3371571; HSF1-dependent transactivation.
DR   Reactome; R-DRE-9833482; PKR-mediated signaling.
DR   Bgee; ENSDARG00000021924; Expressed in pharyngeal gill and 21 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0048593; P:camera-type eye morphogenesis; IMP:ZFIN.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   CDD; cd10233; ASKHA_NBD_HSP70_HSPA1; 1.
DR   FunFam; 2.60.34.10:FF:000002; Heat shock 70 kDa; 1.
DR   FunFam; 3.30.420.40:FF:000172; Heat shock 70 kDa protein; 1.
DR   FunFam; 3.30.30.30:FF:000001; heat shock 70 kDa protein-like; 1.
DR   FunFam; 3.30.420.40:FF:000028; heat shock 70 kDa protein-like; 1.
DR   FunFam; 3.30.420.40:FF:000135; Heat shock cognate 71 kDa protein; 1.
DR   FunFam; 3.90.640.10:FF:000134; Heat shock cognate 71 kDa protein; 1.
DR   FunFam; 1.20.1270.10:FF:000003; heat shock cognate 71 kDa protein-like; 1.
DR   FunFam; 3.30.420.40:FF:000026; Heat shock protein 70; 1.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 3.30.30.30; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 3.90.640.10; Actin, Chain A, domain 4; 1.
DR   Gene3D; 2.60.34.10; Substrate Binding Domain Of DNAk, Chain A, domain 1; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   NCBIfam; NF001413; PRK00290.1; 1.
DR   PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR   SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU003322};
KW   Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT   REGION          620..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        624..636
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  70470 MW;  EBC67C8CAD366161 CRC64;
     MSSPKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ
     VAMNPNNTVF DAKRLIGRRF DDPVVQSDMK HWSFKVVSDG GKPKVAVEHK GENKTFNPEE
     ISSMVLVKMK EIAEAYLGQK VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA
     AAIAYGLDKG KSSERNVLIF DLGGGTFDVS ILTIEDGIFE VKATAGDTHL GGEDFDNRMV
     NHFVEEFKRK HKKDISQNKR ALRRLRTACE RAKRTLSSSS QASIEIDSLY EGIDFYTSIT
     RARFEELCSD LFRGTLDPVE KALRDAKMDK AQIHDIVLVG GSTRIPKIQK LLQDFFNGRE
     LNKSINPDEA VAYGAAVQAA ILMGDTSGNV QDLLLLDVAP LSLGIETAGG VMTALIKRNT
     TIPTKQTQTF TTYSDNQPGV LIQVFEGERA MTKDNNLLGK FELTGIPPAP RGVPQIEVTF
     DIDANGILNV SAADKSTGKQ NKITITNDKG RLSKEEIERM VQEADKYKAE DDLQREKISA
     KNSLESYAFN MKNSVEDDNL KGKISEEDKK RVIEKCNEAV SWLENNQLAD KEEYEHQLKE
     LEKVCNPVIS KLYQGGMPAG GCGAQARGAS GASAQGPTIE EVD
//