ID   G3V6V7_RAT              Unreviewed;       208 AA.
AC   G3V6V7; Q6PCV0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   02-SEP-2026, entry version 98.
DE   RecName: Full=T-cell surface glycoprotein CD8 beta chain {ECO:0000256|ARBA:ARBA00072266};
GN   Name=Cd8b {ECO:0000313|Ensembl:ENSRNOP00000009392.6,
GN   ECO:0000313|RGD:2317};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000009392.6, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000009392.6}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009392.6};
RA   Doris P.A., Kalbfleisch T., Li K., Howe K., Wood J.;
RT   "GRCr8: a new rat reference genome assembly contstructed from accurate long
RT   reads and long range scaffolding.";
RL   Submitted (JAN-2024) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000009392.6}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000009392.6};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
CC   -!- SUBUNIT: Forms disulfide-linked heterodimers with CD8A at the cell
CC       surface. Interacts with CD3D; this interaction couples TCR-CD3 with
CC       CD8. Interacts with LCK. {ECO:0000256|ARBA:ARBA00061995}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00114}.
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DR   RefSeq; NP_113727.2; NM_031539.2.
DR   AlphaFoldDB; G3V6V7; -.
DR   SMR; G3V6V7; -.
DR   Ensembl; ENSRNOT00000009392.9; ENSRNOP00000009392.6; ENSRNOG00000007129.9.
DR   GeneID; 24931; -.
DR   KEGG; rno:24931; -.
DR   CTD; 926; -.
DR   RGD; 2317; Cd8b.
DR   GeneTree; ENSGT00510000048998; -.
DR   HOGENOM; CLU_089344_0_0_1; -.
DR   OMA; RLWLRIH; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000007129; Expressed in thymus and 11 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-ARBA.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0042288; F:MHC class I protein binding; IEA:InterPro.
DR   GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR   CDD; cd07700; IgV_CD8_beta; 1.
DR   FunFam; 2.60.40.10:FF:000645; T-cell surface glycoprotein CD8 beta chain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR042414; CD8B.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR11292; T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN; 1.
DR   PANTHER; PTHR11292:SF7; T-CELL SURFACE GLYCOPROTEIN CD8 BETA CHAIN-RELATED; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   4: Predicted;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319, ECO:0000256|PROSITE-
KW   ProRule:PRU00114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..208
FT                   /note="T-cell surface glycoprotein CD8 beta chain"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015091708"
FT   TRANSMEM        168..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          20..115
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   208 AA;  23389 MW;  982DA164DFA1AEDA CRC64;
     MQPWLWLVFS VKLSALWGSS ALLQTPSSLL VQTNQTAKMS CEAKTFPKGT TIYWLRELQD
     SNKNKHFEFL ASRTSTKGIK YGERVKKNMT LSFNSTLPFL KIMDVKPEDS GFYFCAMVGS
     PMVVFGTGTK LTVVDVLPTT APTKKTTLKK KQCPTPHPKT QKGLTCGLIT LSLLVACILV
     LLVSLSVAIH FHCTRRRARI RFMKQFHK
//