Q6N0T9 HGD_RHOPA Homogentisate 1,2-dioxygenase HGDO 1.13.11.5 Homogentisate oxygenase Homogentisic acid oxidase Homogentisicase hmgA RPA4672 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) Bacteria Pseudomonadati Pseudomonadota Alphaproteobacteria Hyphomicrobiales Nitrobacteraceae Rhodopseudomonas NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] ATCC BAA-98 / CGA009 Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. homogentisate + O2 = 4-maleylacetoacetate + H(+) Fe cation Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. Hexamer; dimer of trimers. Belongs to the homogentisate dioxygenase family. Dioxygenase Iron Metal-binding Oxidoreductase Phenylalanine catabolism Tyrosine catabolism Fe cation Fe cation homogentisate Fe cation homogentisate MNINAAPQILGRSSQDITPGYMSGFGNSFETEALPGALPVGRNSPQRCAYGLYAEQLSGSPFTAPRGANERSWLYRIRPSVKHSGRFAKTDMGLWRSAPCFEHDLPIAQLRWDPPPMPQEALTFLQGVRTMTTAGDVNTQAGMATHLYLITQSMVDQHFYNADGEMMFVPQQGSLRLVTEFGIITIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDFLTPVAAYEDKDTPTELYVKWGGSLYVTKLPHSPIDVVAWHGNYAPYKYDLRTYSPVGAIGFDHPDPSIFTVLTSPSETPGTANIDFVIFPERWMVADNTFRPPWYHMNIMSEFMGLIYGVYDAKPQGFVPGGASLHNMMLPHGPDREAFDHASNGELKPVKLTGTMAFMFETRYPQRVTEYAASSGLLQDDYADCWNGLEKRFDPNRP Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License