ID   Q6LS46_PHOPR            Unreviewed;       367 AA.
AC   Q6LS46;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   04-NOV-2026, entry version 128.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase {ECO:0000256|HAMAP-Rule:MF_00137};
DE            EC=6.3.2.6 {ECO:0000256|HAMAP-Rule:MF_00137};
DE   AltName: Full=SAICAR synthetase {ECO:0000256|HAMAP-Rule:MF_00137};
GN   Name=purC {ECO:0000256|HAMAP-Rule:MF_00137};
GN   OrderedLocusNames=PBPRA1469 {ECO:0000313|EMBL:CAG19880.1};
OS   Photobacterium profundum (strain SS9).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Photobacterium.
OX   NCBI_TaxID=298386 {ECO:0000313|EMBL:CAG19880.1, ECO:0000313|Proteomes:UP000000593};
RN   [1] {ECO:0000313|Proteomes:UP000000593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1253 / SS9 {ECO:0000313|Proteomes:UP000000593};
RX   PubMed=15746425; DOI=10.1126/science.1103341;
RA   Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA   Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA   Bartlett D.H., Valle G.;
RT   "Life at depth: Photobacterium profundum genome sequence and expression
RT   analysis.";
RL   Science 307:1459-1461(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-
CC         aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-
CC         ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+);
CC         Xref=Rhea:RHEA:22628, ChEBI:CHEBI:15378, ChEBI:CHEBI:29991,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58443,
CC         ChEBI:CHEBI:77657, ChEBI:CHEBI:456216; EC=6.3.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00048475, ECO:0000256|HAMAP-
CC         Rule:MF_00137};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
CC       {ECO:0000256|ARBA:ARBA00004672, ECO:0000256|HAMAP-Rule:MF_00137}.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
CC       {ECO:0000256|ARBA:ARBA00010190, ECO:0000256|HAMAP-Rule:MF_00137}.
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DR   EMBL; CR378667; CAG19880.1; -; Genomic_DNA.
DR   RefSeq; WP_011218202.1; NC_006370.1.
DR   AlphaFoldDB; Q6LS46; -.
DR   STRING; 298386.PBPRA1469; -.
DR   KEGG; ppr:PBPRA1469; -.
DR   eggNOG; COG0152; Bacteria.
DR   HOGENOM; CLU_064197_0_0_6; -.
DR   OMA; ADEWEPG; -.
DR   UniPathway; UPA00074; UER00131.
DR   Proteomes; UP000000593; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01414; SAICAR_synt_Sc; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   HAMAP; MF_00137; SAICAR_synth; 1.
DR   InterPro; IPR028923; SAICAR_synt/ADE2_N.
DR   InterPro; IPR014106; SAICAR_synthase_Vibrio-typ.
DR   NCBIfam; NF010567; PRK13960.1; 1.
DR   NCBIfam; TIGR02735; purC_vibrio; 1.
DR   PANTHER; PTHR43700; PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; 1.
DR   PANTHER; PTHR43700:SF1; PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE; 1.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   SUPFAM; SSF56104; SAICAR synthase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00137};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00137};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00137};
KW   Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755, ECO:0000256|HAMAP-
KW   Rule:MF_00137}; Reference proteome {ECO:0000313|Proteomes:UP000000593}.
FT   DOMAIN          47..295
FT                   /note="SAICAR synthetase/ADE2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01259"
SQ   SEQUENCE   367 AA;  41499 MW;  7D4664C0DAE26B69 CRC64;
     MSLADQVLAV NDDLPIRTDK PVHSGKVRSV YWLTEADSRR LIEEKGYNVA PDAPLAIMVI
     SDRISAFDCI WHGEGGMKGV PGKGAALNAI SNHWFKLFRD NDLAESHILD IPHPFIWIVQ
     KAKPVMIEAI CRQYITGSMW RSYSKGERDF CGIEVPEGLN KDQKLPELLI TPSTKGILEG
     IPGVPAVDDV NITRKNIEEN FEAFNFRNTD DINHYEKLLQ EGFDVISSEL EKLDQIFVDT
     KFEFGYVTDA SGKEKLIYMD EVGTPDSSRI WDAAAYRDGK IVENSKEDFR QLLLNHFPDP
     DILLNKDRME ERSALARDNA LPEEVLMQVS KIYTDIAEKI TGKKIVLSKN PKAEITAILR
     DQYGLVD
//