ID   Q6DF36_XENTR            Unreviewed;       216 AA.
AC   Q6DF36; F7CEP9;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   02-SEP-2026, entry version 141.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|ARBA:ARBA00017144};
DE            EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
DE   AltName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00029962};
GN   Name=dtymk {ECO:0000313|EMBL:AAH76907.1,
GN   ECO:0000313|Xenbase:XB-GENE-1004306};
GN   ORFNames=TEgg023c22.1-001 {ECO:0000313|EMBL:CAJ81735.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH76907.1};
RN   [1] {ECO:0000313|EMBL:AAH76907.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole body {ECO:0000313|EMBL:AAH76907.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAJ81735.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA   Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA   McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA   Zorn A.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the phosphorylation of thymidine monophosphate
CC       (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the
CC       DNA building block dTTP, with ATP as the preferred phosphoryl donor in
CC       the presence of Mg(2+). {ECO:0000256|ARBA:ARBA00056272}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTMP + ATP = dTDP + ADP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9;
CC         Evidence={ECO:0000256|ARBA:ARBA00048743};
CC   -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004992}.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00009776}.
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DR   EMBL; BC076907; AAH76907.1; -; mRNA.
DR   EMBL; CR761321; CAJ81735.1; -; mRNA.
DR   RefSeq; NP_001006834.1; NM_001006833.1.
DR   AlphaFoldDB; Q6DF36; -.
DR   STRING; 8364.ENSXETP00000044270; -.
DR   PaxDb; 8364-ENSXETP00000044270; -.
DR   DNASU; 448574; -.
DR   GeneID; 448574; -.
DR   KEGG; xtr:448574; -.
DR   AGR; Xenbase:XB-GENE-1004306; -.
DR   CTD; 1841; -.
DR   Xenbase; XB-GENE-1004306; dtymk.
DR   eggNOG; KOG3327; Eukaryota.
DR   GeneTree; ENSGT00940000154030; -.
DR   HOGENOM; CLU_049131_3_3_1; -.
DR   OMA; YWHQFDA; -.
DR   OrthoDB; 425602at2759; -.
DR   Reactome; R-XTR-499943; Interconversion of nucleotide di- and triphosphates.
DR   Bgee; ENSXETG00000002980; Expressed in egg cell and 17 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004798; F:dTMP kinase activity; IBA:GO_Central.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006227; P:dUDP biosynthetic process; IBA:GO_Central.
DR   CDD; cd01672; TMPK; 1.
DR   FunFam; 3.40.50.300:FF:000679; Thymidylate kinase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   NCBIfam; TIGR00041; DTMP_kinase; 1.
DR   PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR   PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAH76907.1};
KW   Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          11..190
FT                   /note="Thymidylate kinase-like"
FT                   /evidence="ECO:0000259|Pfam:PF02223"
SQ   SEQUENCE   216 AA;  24508 MW;  ACE3ECCCC3DB79CD CRC64;
     MAGLRGALIV LEGADRAGKS TQARRLVEAL KERGYKTEGL RFPERTTEIG RLIGSYLEKK
     SNLEDHTIHL LFSANRWEQV PMIKEKLRSG VTLVIDRYAF SGVAFTSSKE NFDLHWCKQP
     DVGLPKPDLV LFLNVSPEVA ASRGGFGNEI YETNSFQEKV SKRYAELMED KTVNWTLIDA
     SQNIEDVHRQ LKELTEKAIE DAKDKPIGKL WEEESP
//