ID   Q6CSP3_KLULA            Unreviewed;      1286 AA.
AC   Q6CSP3;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   28-JAN-2026, entry version 97.
DE   SubName: Full=KLLA0C18975p {ECO:0000313|EMBL:CAH01897.1};
GN   ORFNames=KLLA0_C18975g {ECO:0000313|EMBL:CAH01897.1};
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590 {ECO:0000313|EMBL:CAH01897.1, ECO:0000313|Proteomes:UP000000598};
RN   [1] {ECO:0000313|EMBL:CAH01897.1, ECO:0000313|Proteomes:UP000000598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37 {ECO:0000313|Proteomes:UP000000598};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA   Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA   Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; CR382123; CAH01897.1; -; Genomic_DNA.
DR   FunCoup; Q6CSP3; 888.
DR   STRING; 284590.Q6CSP3; -.
DR   PaxDb; 284590-Q6CSP3; -.
DR   KEGG; kla:KLLA0_C18975g; -.
DR   eggNOG; KOG1939; Eukaryota.
DR   HOGENOM; CLU_002157_0_1_1; -.
DR   InParanoid; Q6CSP3; -.
DR   OMA; TDCNVML; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR   GO; GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; IEA:TreeGrafter.
DR   GO; GO:0006749; P:glutathione metabolic process; IEA:TreeGrafter.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase-like.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000598}.
FT   DOMAIN          13..228
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          248..541
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          675..730
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          749..1285
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1286 AA;  140586 MW;  3480EF34F2F1929D CRC64;
     MTVDRSEKTG GIRIAVDRGG TFTDCIGNPG TNRQEDDVVI KLLSVDPKNY PDAPLEGIRR
     LLEIIEDRKI PRGTPLDVSG VKSVRMGTTL ATNCALERNG ERCAFITTLG FKDALLIGDQ
     TRPDIFDLNI RKSEPLYDMV VEVDERVTLE DFSEDPDNVK STENLKDNTV MGTSGEVVRV
     LKRPDLSSIE ATLRLVYDSG IKSIAVALLH AYTYPDHELL IGKIAHKIGF KHVSLSSQVS
     PMIKFLPRAH SSVADAYLTP VIKKYLESIE SGLTNAENTN VQFMQSDGGL VDGKKFSGLK
     SILSGPAGGV VGYSSTCYDD ENRIPLIGFD MGGTSTDVSR YGDGKLEHIF ETTTAGIVIQ
     SPQLDINTVA AGGSSRLFWE NGLFRVGPES ATADPGPAAY RKGGPLTITD ANLFLGRLVP
     EFFPSIFGPN EDETLDLETT TKLFLELTDT INKDLNANFT PDEIAYGFLK VANESMARPI
     RAITEAKGHA VQNHRLVTFG GAGGQHAVAV AKSLGIKEVL AHRYSSILSA YGIFLADVVE
     EKQEPCSFIL EDSSTMDKVK LRFDNLCAMS KASFRNQGFD DSDLVFEKYL NLRYEGTETS
     LMILQEDDSY EFKKWFSRCH KTEFGFDSAD KNIIVDDIRV RTIAKSNVRK EDSVDSQLSM
     LSRNAIDRKT HASFTKLVYF NGKRVETPVY RIEKMPLGSV ITGPAILADG TQTNVIPPNT
     EAVILKSHIF IKLLSAVDDA KPVSDDEIDP VLLSIFSHRF MDIAEQMGNQ LRKTSVSTNV
     KERLDFSCAL FDNTGNLVAN APHVPVHLGS MSTCIAAQAK LWKGKLKPGD VIITNHPEIG
     GTHLPDITII TPAFSEKTGE LIFYVASRAH HADIGGILPG SVPPNSKELY EEGAAIYSEL
     ITKDGEFQND LVKEYLLYKP AQYPKCSGSR KISDNISDLK AQVAANNKGI QLIQKLNEEY
     GITVIKRYME AIQDNASTTI KSMLRKMANH FNTTEFSGED LMDDGSTIKL KVNLDVENEE
     YTFDFEGTSP QIYGNLNAPE AITNSAILYC LRCLVGEDIP LNQGCLKPLT IKIPKGSILS
     PTKGMAVVGG NVLTSQRVTD VVLKTFQVMA DSQGDCNNFT FGTGGKDPIT GETKDGFGYY
     ETICGGHGAG CDSWRGNGWN GADAVHTNMT NTRITDVEIF ERRYPVILNE FSIRQNSGGK
     GKYKGGNGIV RDITFRKEVQ ASILSERRVI APHGIAGGGD GARGMNIWVR HETNSKVNMG
     GKNTVPIRPG DRVIIMTPGG GGCGRA
//