ID   NRDR_MANSM              Reviewed;         149 AA.
AC   Q65SS8;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   02-SEP-2026, entry version 111.
DE   RecName: Full=Transcriptional repressor NrdR {ECO:0000255|HAMAP-Rule:MF_00440};
GN   Name=nrdR {ECO:0000255|HAMAP-Rule:MF_00440}; OrderedLocusNames=MS1375;
OS   Mannheimia succiniciproducens (strain KCTC 0769BP / MBEL55E).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pasteurellales; Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 0769BP / MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: Negatively regulates transcription of bacterial
CC       ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC       boxes. {ECO:0000255|HAMAP-Rule:MF_00440}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00440};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00440};
CC   -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000255|HAMAP-
CC       Rule:MF_00440}.
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DR   EMBL; AE016827; AAU37982.1; -; Genomic_DNA.
DR   RefSeq; WP_011200549.1; NC_006300.1.
DR   AlphaFoldDB; Q65SS8; -.
DR   SMR; Q65SS8; -.
DR   STRING; 221988.MS1375; -.
DR   KEGG; msu:MS1375; -.
DR   eggNOG; COG1327; Bacteria.
DR   HOGENOM; CLU_108412_0_0_6; -.
DR   OrthoDB; 9807461at2; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00440; NrdR; 1.
DR   InterPro; IPR005144; ATP-cone_dom.
DR   InterPro; IPR055173; NrdR-like_N.
DR   InterPro; IPR003796; RNR_NrdR-like.
DR   NCBIfam; TIGR00244; transcriptional regulator NrdR; 1.
DR   PANTHER; PTHR30455; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR   PANTHER; PTHR30455:SF2; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR   Pfam; PF03477; ATP-cone; 1.
DR   Pfam; PF22811; Zn_ribbon_NrdR; 1.
DR   PROSITE; PS51161; ATP_CONE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..149
FT                   /note="Transcriptional repressor NrdR"
FT                   /id="PRO_0000182316"
FT   DOMAIN          49..139
FT                   /note="ATP-cone"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
FT   ZN_FING         3..34
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00440"
SQ   SEQUENCE   149 AA;  17326 MW;  53A74AB7349E1138 CRC64;
     MHCPFCSTEE TKVIDSRLVS DGYQVRRRRE CTKCHERFTT FETAELVVPK IIKNNGMREP
     FNEDKLRRGI QHALEKRPVS ADDVEKAISH ITHQLRATGE REVPSKLVGS LVMEELKKLD
     KVAYIRFASV YLSFENINEF SNEIEKLKD
//