ID   MUTL_MANSM              Reviewed;         631 AA.
AC   Q65SD7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   28-JAN-2026, entry version 125.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=MS1516;
OS   Mannheimia succiniciproducens (strain KCTC 0769BP / MBEL55E).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pasteurellales; Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 0769BP / MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; AE016827; AAU38123.1; -; Genomic_DNA.
DR   RefSeq; WP_011200689.1; NC_006300.1.
DR   AlphaFoldDB; Q65SD7; -.
DR   SMR; Q65SD7; -.
DR   STRING; 221988.MS1516; -.
DR   KEGG; msu:MS1516; -.
DR   eggNOG; COG0323; Bacteria.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03482; MutL_Trans_MutL; 1.
DR   FunFam; 3.30.230.10:FF:000013; DNA mismatch repair endonuclease MutL; 1.
DR   FunFam; 3.30.565.10:FF:000003; DNA mismatch repair endonuclease MutL; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   NCBIfam; NF000948; PRK00095.1-1; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..631
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010041"
SQ   SEQUENCE   631 AA;  70906 MW;  D009C3A26B8235A8 CRC64;
     MPIHILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAS RIQIDIENGG ATLIRIRDNG
     LGIAKEDLSL ALARHATSKI SCLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTAEQKEA
     WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTEKTEFAH IDEVVRRIAL
     AKPQIAFTLT HNGKILRQYK SAVEIEQKLK RVSAICGEDF VQNALQIDWK HDNLHLSGWV
     AVPNFHRPQN DLSYSYVNGR MIRDKVINHA IRQAYGDYLT NEQYPAFVLY LDLDPNEVDV
     NVHPTKHEVR FHQARLIHDF ICQGVGNALQ SEQADFARYD TPASADEIQE PAANWHSSLI
     KPNRSAAGHN IFESASDKNI SGANTYSHGS AKINRFSTKF AENIPHFSTK SVSKTEQKLY
     GNLLTTPAEA KKNTAINAES ENSFEKNVST PQQSTQLSGQ FLHSLALVKN QALLLQQGQD
     FYLLPLAKLQ KLKFELTLQQ PDIAQQPLLI PILFRLNERQ LAQWQKQKNF FLQSGFEFDE
     NPAQHRITLN KVPSCLRQQN LQGCVIRLLE ENHEKISDFL TALCNQLQLN EIHVLADALT
     LLTEVELLLK TQNKIQLAQL LISVDFTQYL Q
//