ID   Q65DF6_BACLD            Unreviewed;       479 AA.
AC   Q65DF6; Q62NX6;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   04-NOV-2026, entry version 123.
DE   SubName: Full=2-methylisocitrate dehydratase {ECO:0000313|EMBL:AAU25535.1};
GN   Name=mmgE {ECO:0000313|EMBL:AAU25535.1};
GN   OrderedLocusNames=BL00562 {ECO:0000313|EMBL:AAU25535.1};
OS   Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 /
OS   NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46).
OC   Bacteria; Bacillati; Bacillota; Bacilli; Caryophanales; Bacillaceae;
OC   Bacillus.
OX   NCBI_TaxID=279010 {ECO:0000313|EMBL:AAU25535.1, ECO:0000313|Proteomes:UP000000606};
RN   [1] {ECO:0000313|EMBL:AAU25535.1, ECO:0000313|Proteomes:UP000000606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB
RC   9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46
RC   {ECO:0000313|Proteomes:UP000000606};
RX   PubMed=15461803; DOI=10.1186/gb-2004-5-10-r77;
RA   Rey M.W., Ramaiya P., Nelson B.A., Brody-Karpin S.D., Zaretsky E.J.,
RA   Tang M., Lopez de Leon A., Xiang H., Gusti V., Clausen I.G., Olsen P.B.,
RA   Rasmussen M.D., Andersen J.T., Jorgensen P.L., Larsen T.S., Sorokin A.,
RA   Bolotin A., Lapidus A., Galleron N., Ehrlich S.D., Berka R.M.;
RT   "Complete genome sequence of the industrial bacterium Bacillus
RT   licheniformis and comparisons with closely related Bacillus species.";
RL   Genome Biol. 5:R77.1-R77.12(2004).
CC   -!- SIMILARITY: Belongs to the PrpD family.
CC       {ECO:0000256|ARBA:ARBA00006174}.
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DR   EMBL; CP000002; AAU25535.1; -; Genomic_DNA.
DR   RefSeq; WP_011198422.1; NC_006270.3.
DR   AlphaFoldDB; Q65DF6; -.
DR   STRING; 279010.BL00562; -.
DR   GeneID; 92859333; -.
DR   KEGG; bld:BLi04095; -.
DR   KEGG; bli:BL00562; -.
DR   PATRIC; fig|279010.13.peg.4174; -.
DR   eggNOG; COG2079; Bacteria.
DR   HOGENOM; CLU_021803_1_0_9; -.
DR   OMA; AAEHYED; -.
DR   Proteomes; UP000000606; Chromosome.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0047547; F:2-methylcitrate dehydratase activity; IEA:InterPro.
DR   GO; GO:0019543; P:propionate catabolic process; IEA:InterPro.
DR   FunFam; 3.30.1330.120:FF:000001; 2-methylcitrate dehydratase; 1.
DR   Gene3D; 1.10.4100.10; 2-methylcitrate dehydratase PrpD; 1.
DR   Gene3D; 3.30.1330.120; 2-methylcitrate dehydratase PrpD; 1.
DR   InterPro; IPR012705; 2Me_IsoCit_deHydtase_PrpD.
DR   InterPro; IPR036148; MmgE/PrpD_sf.
DR   InterPro; IPR042183; MmgE/PrpD_sf_1.
DR   InterPro; IPR042188; MmgE/PrpD_sf_2.
DR   InterPro; IPR005656; MmgE_PrpD.
DR   InterPro; IPR045337; MmgE_PrpD_C.
DR   InterPro; IPR045336; MmgE_PrpD_N.
DR   NCBIfam; NF006943; PRK09425.1; 1.
DR   NCBIfam; TIGR02330; prpD; 1.
DR   PANTHER; PTHR16943:SF8; 2-METHYLCITRATE DEHYDRATASE; 1.
DR   PANTHER; PTHR16943; 2-METHYLCITRATE DEHYDRATASE-RELATED; 1.
DR   Pfam; PF19305; MmgE_PrpD_C; 1.
DR   Pfam; PF03972; MmgE_PrpD_N; 1.
DR   SUPFAM; SSF103378; 2-methylcitrate dehydratase PrpD; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000606};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          16..267
FT                   /note="MmgE/PrpD N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03972"
FT   DOMAIN          286..457
FT                   /note="MmgE/PrpD C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19305"
SQ   SEQUENCE   479 AA;  52976 MW;  7E24E2A1A82AFA70 CRC64;
     MKTESQTLQN CDQLLEEIAD YTVNAKISSE EAIETARYVL MDTLGCGILA LKYPECAKHL
     GPIAPGTVVP NGTRVPGTQF ELDPVHGAFN IGCMIRWLDY NDTWLAAEWG HPSDNLGAIL
     ACADYVSRQL LAAGKEPLTI NDVLTAIVKA HEIQGVLALD NSLNRNGLDH VLFVKVASTA
     VACSLLGGTK QDVINAVSQA WVDNSSLRTY RHAPNTGSRK SWAAGDATSR GVRLAMMTLK
     GEMGYKTALS APMWGFQDVL FGGKELTLAR PLDSYVIENV LFKISYPAEF HAQTAAEAAI
     RLHPEVKDRL DDIGQIVITT HESAIRIIDK TGELHNPADR DHCLQYITAI GLIYGDITAD
     HYEDETAQNP EIDRLREKMT TVENKQYSVD YLDPEKRSIA NAVQVFYKDG THSEKIAVEY
     PIGHRRRRNE GIPLLKDKFI NNLKTRFPAG QAERINALLN DPHRLSGAPV PDFMELFVI
//