##gff-version 3 Q63604 UniProtKB Signal peptide 1 31 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q63604 UniProtKB Chain 32 821 . . . ID=PRO_0000016729;Note=BDNF/NT-3 growth factors receptor Q63604 UniProtKB Topological domain 32 429 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Transmembrane 430 453 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Topological domain 454 821 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Domain 32 61 . . . Note=LRRNT Q63604 UniProtKB Repeat 92 113 . . . Note=LRR 1 Q63604 UniProtKB Repeat 116 137 . . . Note=LRR 2 Q63604 UniProtKB Domain 148 196 . . . Note=LRRCT Q63604 UniProtKB Domain 197 282 . . . Note=Ig-like C2-type 1 Q63604 UniProtKB Domain 295 365 . . . Note=Ig-like C2-type 2 Q63604 UniProtKB Domain 537 806 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q63604 UniProtKB Region 454 465 . . . Note=Interaction with MAPK8IP3/JIP3;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21775604;Dbxref=PMID:21775604 Q63604 UniProtKB Region 474 497 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q63604 UniProtKB Compositional bias 484 494 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q63604 UniProtKB Active site 675 675 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 Q63604 UniProtKB Binding site 543 551 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q63604 UniProtKB Binding site 571 571 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 Q63604 UniProtKB Site 515 515 . . . Note=Interaction with SHC1 Q63604 UniProtKB Site 705 705 . . . Note=Interaction with SH2D1A Q63604 UniProtKB Site 816 816 . . . Note=Interaction with PLCG1;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q63604 UniProtKB Modified residue 515 515 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P15209 Q63604 UniProtKB Modified residue 701 701 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8106527;Dbxref=PMID:8106527 Q63604 UniProtKB Modified residue 705 705 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8106527;Dbxref=PMID:8106527 Q63604 UniProtKB Modified residue 706 706 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8106527;Dbxref=PMID:8106527 Q63604 UniProtKB Modified residue 816 816 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8106527;Dbxref=PMID:8106527 Q63604 UniProtKB Glycosylation 67 67 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 95 95 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24090084;Dbxref=PMID:24090084 Q63604 UniProtKB Glycosylation 121 121 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 178 178 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 205 205 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 241 241 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24090084;Dbxref=PMID:24090084 Q63604 UniProtKB Glycosylation 254 254 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 280 280 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 325 325 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 338 338 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 350 350 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Glycosylation 411 411 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q63604 UniProtKB Disulfide bond 32 38 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q63604 UniProtKB Disulfide bond 36 45 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q63604 UniProtKB Disulfide bond 152 176 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q63604 UniProtKB Disulfide bond 154 194 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q63604 UniProtKB Disulfide bond 218 266 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q63604 UniProtKB Disulfide bond 302 345 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 Q63604 UniProtKB Alternative sequence 466 476 . . . ID=VSP_002910;Note=In isoform T1. PASVISNDDDS->FVLFHKIPLDG;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q63604 UniProtKB Alternative sequence 466 474 . . . ID=VSP_002912;Note=In isoform T2. PASVISNDD->KQKCAYFAS;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q63604 UniProtKB Alternative sequence 475 821 . . . ID=VSP_002913;Note=In isoform T2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q63604 UniProtKB Alternative sequence 477 821 . . . ID=VSP_002911;Note=In isoform T1. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q63604 UniProtKB Mutagenesis 515 515 . . . Note=Loss of interaction with SHC1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10196222;Dbxref=PMID:10196222 Q63604 UniProtKB Mutagenesis 571 571 . . . Note=Loss of kinase activity. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582017;Dbxref=PMID:9582017 Q63604 UniProtKB Mutagenesis 701 701 . . . Note=Loss of autophosphorylation and altered interaction with SHC1 and PLCG1%3B when associated with F-705 and F-706. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582017;Dbxref=PMID:9582017 Q63604 UniProtKB Mutagenesis 705 705 . . . Note=Loss of autophosphorylation%3B when associated with F-701 and F-706. Y->F;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16223723,ECO:0000269|PubMed:9582017;Dbxref=PMID:16223723,PMID:9582017 Q63604 UniProtKB Mutagenesis 706 706 . . . Note=Loss of autophosphorylation%3B when associated with F-701 and F-705. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9582017;Dbxref=PMID:9582017