ID   Q5ZWI0_LEGPH            Unreviewed;       167 AA.
AC   Q5ZWI0;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   02-SEP-2026, entry version 119.
DE   RecName: Full=peptide-methionine (R)-S-oxide reductase {ECO:0000256|ARBA:ARBA00012499};
DE            EC=1.8.4.12 {ECO:0000256|ARBA:ARBA00012499};
GN   OrderedLocusNames=lpg1105 {ECO:0000313|EMBL:AAU27191.1};
OS   Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC
OS   33152 / DSM 7513).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Legionellales; Legionellaceae; Legionella.
OX   NCBI_TaxID=272624 {ECO:0000313|EMBL:AAU27191.1, ECO:0000313|Proteomes:UP000000609};
RN   [1] {ECO:0000313|EMBL:AAU27191.1, ECO:0000313|Proteomes:UP000000609}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Philadelphia 1 / ATCC 33152 / DSM 7513
RC   {ECO:0000313|Proteomes:UP000000609};
RX   PubMed=15448271; DOI=10.1126/science.1099776;
RA   Chien M., Morozova I., Shi S., Sheng H., Chen J., Gomez S.M., Asamani G.,
RA   Hill K., Nuara J., Feder M., Rineer J., Greenberg J.J., Steshenko V.,
RA   Park S.H., Zhao B., Teplitskaya E., Edwards J.R., Pampou S., Georghiou A.,
RA   Chou I.C., Iannuccilli W., Ulz M.E., Kim D.H., Geringer-Sameth A.,
RA   Goldsberry C., Morozov P., Fischer S.G., Segal G., Qu X., Rzhetsky A.,
RA   Zhang P., Cayanis E., De Jong P.J., Ju J., Kalachikov S., Shuman H.A.,
RA   Russo J.J.;
RT   "The genomic sequence of the accidental pathogen Legionella pneumophila.";
RL   Science 305:1966-1968(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-
CC         methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol;
CC         Xref=Rhea:RHEA:24164, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700,
CC         Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12314, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:45764,
CC         ChEBI:CHEBI:50058; EC=1.8.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00048488};
CC   -!- SIMILARITY: Belongs to the MsrB Met sulfoxide reductase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01126}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01126}.
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DR   EMBL; AE017354; AAU27191.1; -; Genomic_DNA.
DR   RefSeq; WP_010946839.1; NC_002942.5.
DR   AlphaFoldDB; Q5ZWI0; -.
DR   STRING; 272624.lpg1105; -.
DR   PaxDb; 272624-lpg1105; -.
DR   GeneID; 57035091; -.
DR   KEGG; lpn:lpg1105; -.
DR   PATRIC; fig|272624.6.peg.1155; -.
DR   eggNOG; COG0229; Bacteria.
DR   HOGENOM; CLU_031040_8_5_6; -.
DR   OrthoDB; 4174719at2; -.
DR   Proteomes; UP000000609; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030091; P:protein repair; IEA:InterPro.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   FunFam; 2.170.150.20:FF:000003; Peptide methionine sulfoxide reductase MsrB; 1.
DR   Gene3D; 2.170.150.20; Peptide methionine sulfoxide reductase; 1.
DR   InterPro; IPR028427; Met_Sox_Rdtase_MsrB.
DR   InterPro; IPR002579; Met_Sox_Rdtase_MsrB_dom.
DR   InterPro; IPR011057; Mss4-like_sf.
DR   NCBIfam; TIGR00357; peptide-methionine (R)-S-oxide reductase MsrB; 1.
DR   PANTHER; PTHR10173; METHIONINE SULFOXIDE REDUCTASE; 1.
DR   PANTHER; PTHR10173:SF59; PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA_MSRB; 1.
DR   Pfam; PF01641; SelR; 1.
DR   SUPFAM; SSF51316; Mss4-like; 1.
DR   PROSITE; PS51790; MSRB; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|PROSITE-
KW   ProRule:PRU01126}; Reference proteome {ECO:0000313|Proteomes:UP000000609};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..167
FT                   /note="peptide-methionine (R)-S-oxide reductase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004265360"
FT   DOMAIN          26..149
FT                   /note="MsrB"
FT                   /evidence="ECO:0000259|PROSITE:PS51790"
FT   ACT_SITE        138
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01126"
SQ   SEQUENCE   167 AA;  19312 MW;  A54CB56F4BEDDBC7 CRC64;
     MTKLISVVFY LFIIPNVMAY TPQFNKSEQL KKLTPLQYQV TQNGATEKSF DNAYWNNKEE
     GIYVDIVSGE PLFSSNDKYD SGTGWPSFTK PIDTSYLVFH TDRSYFFIVR TEVRSKYANS
     HLGHVFKDGP EPTGLRYCMN SAALKFIPKK EMEQAGYGEY LYLFNKK
//