Q9UBQ7 Q5T945 Q9H3E9 Q9H636 Q9UKX1 GRHPR_HUMAN Glyoxylate reductase/hydroxypyruvate reductase 1.1.1.79 1.1.1.81 GRHPR GLXR MSTP035 Homo sapiens Human Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Identification and expression of a cDNA for human hydroxypyruvate/glyoxylate reductase. NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) SUBUNIT CATALYTIC ACTIVITY FUNCTION Liver The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II. NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1) INVOLVEMENT IN HP2 CATALYTIC ACTIVITY FUNCTION Liver NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) Aorta Complete sequencing and characterization of 21,243 full-length human cDNAs. NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2) Small intestine Testis DNA sequence and analysis of human chromosome 9. NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) Kidney Cloning and characterization of a putative human D-2-hydroxyacid dehydrogenase in chromosome 9q. NUCLEOTIDE SEQUENCE [MRNA] OF 45-328 (ISOFORM 1) TISSUE SPECIFICITY Initial characterization of the human central proteome. IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-272 AND THR-298 IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Liver N-terminome analysis of the human mitochondrial proteome. IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase. X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH NADP AND SUBSTRATE SUBUNIT Crystal structure of a glyoxylate/hydroxypyruvate reductase from Homo sapiens. X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 2-328 Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate, oxidizes D-glycerate to hydroxypyruvate. glycolate + NADP(+) = glyoxylate + NADPH + H(+) (R)-glycerate + NAD(+) = 3-hydroxypyruvate + NADH + H(+) (R)-glycerate + NADP(+) = 3-hydroxypyruvate + NADPH + H(+) Homodimer. Q9UBQ7 Q9UHI7 false 6 Q9UBQ7-1 1 Q9UBQ7-2 2 Ubiquitous. Most abundantly expressed in the liver. Hyperoxaluria primary 2 HP2 A disorder characterized by elevated urinary excretion of oxalate and L-glycerate, progressive tissue accumulation of insoluble calcium oxalate, nephrolithiasis, nephrocalcinosis, and end-stage renal disease. The disease is caused by variants affecting the gene represented in this entry. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. 3D-structure Alternative splicing NADP Oxidoreductase Phosphoprotein Proteomics identification Reference proteome substrate NADP(+) NADP(+) NADP(+) NADP(+) substrate substrate substrate NADP(+) MRPVRLMKVFVTRRIPAEGRV MLGGVPTLCGTGNETWTLLAL GDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL YPRATLPSKPGEEPSPLLPSGDFLPRGLLVRPQAELAGFHKPNNQLRNSWEYTRPPYREEEPSEWAWPVCFSAVAPTRRGLAHSSVASGSVPREPLQAHYPPPQRAGLEDLKGPLEAASHTAEPGFVWLWFSDTLNLMLLGGQTLKLTWS R Q MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHRTRNTMSLLAANNLLAGLRGEPMPSELKL Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License