ID   Q5LIN7_BACFN            Unreviewed;       384 AA.
AC   Q5LIN7;
DT   21-JUN-2005, integrated into UniProtKB/TrEMBL.
DT   21-JUN-2005, sequence version 1.
DT   02-SEP-2026, entry version 95.
DE   SubName: Full=Lactaldehyde reductase {ECO:0000313|EMBL:CAH05989.1};
DE            EC=1.1.1.77 {ECO:0000313|EMBL:CAH05989.1};
GN   Name=fucO {ECO:0000313|EMBL:CAH05989.1};
GN   ORFNames=BF9343_0210 {ECO:0000313|EMBL:CAH05989.1};
OS   Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019
OS   / LMG 10263 / NCTC 9343 / Onslow / VPI 2553 / EN-2).
OC   Bacteria; Pseudomonadati; Bacteroidota; Bacteroidia; Bacteroidales;
OC   Bacteroidaceae; Bacteroides.
OX   NCBI_TaxID=272559 {ECO:0000313|EMBL:CAH05989.1, ECO:0000313|Proteomes:UP000006731};
RN   [1] {ECO:0000313|EMBL:CAH05989.1, ECO:0000313|Proteomes:UP000006731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / LMG 10263 /
RC   NCTC 9343 / Onslow / VPI 2553 / EN-2
RC   {ECO:0000313|Proteomes:UP000006731};
RX   PubMed=15746427; DOI=10.1126/science.1107008;
RA   Cerdeno-Tarraga A.M., Patrick S., Crosmann L., Blakely G., Abratt V.,
RA   Lennard N., Duerden B., Poxton I., Harris B., Quail M.A., Barron A.,
RA   Clarck L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A.,
RA   Lord A., Norbertczak H., Ormond D., Price C., Rabbinowitsch E.,
RA   Woodward J., Barrel B.G., Parkhill J.;
RT   "Extensive DNA inversions in the B. fragilis genome control variable gene
RT   expression.";
RL   Science 307:1463-1465(2005).
CC   -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00007358}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR626927; CAH05989.1; -; Genomic_DNA.
DR   RefSeq; WP_005801896.1; NC_003228.3.
DR   AlphaFoldDB; Q5LIN7; -.
DR   GeneID; 60368630; -.
DR   KEGG; bfs:BF9343_0210; -.
DR   eggNOG; COG1454; Bacteria.
DR   HOGENOM; CLU_007207_0_0_10; -.
DR   BioCyc; BFRA272559:G1GHZ-218-MONOMER; -.
DR   Proteomes; UP000006731; Chromosome.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:TreeGrafter.
DR   GO; GO:0008912; F:lactaldehyde reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd08176; LPO; 1.
DR   FunFam; 3.40.50.1970:FF:000003; Alcohol dehydrogenase, iron-containing; 1.
DR   FunFam; 1.20.1090.10:FF:000001; Aldehyde-alcohol dehydrogenase; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR056798; ADH_Fe_C.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR013460; Lactal_redase.
DR   NCBIfam; TIGR02638; lactal_redase; 1.
DR   NCBIfam; NF007911; PRK10624.1; 1.
DR   PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR   Pfam; PF25137; ADH_Fe_C; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
DR   PROSITE; PS00060; ADH_IRON_2; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:CAH05989.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006731}.
FT   DOMAIN          12..177
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
FT   DOMAIN          189..384
FT                   /note="Fe-containing alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF25137"
SQ   SEQUENCE   384 AA;  41018 MW;  C6D8618BFD7DFB45 CRC64;
     MINRFILNEV SYFGPGAREV LPKEISRLGL HKAFVATDKD LIKFGVADKV LKVLEAAKIP
     YEIFSEIKPN PTVSNVKAGV EAFASSGADF ILAIGGGSSM DTAKAIGIIT NNPEFSDVVS
     LEGVADTKKK SVPIIALPTT AGTAAEVTIN YVITDEKNQK KMVCVDPNDI PSIAIVDAEL
     MYTLPKSLTA ATGLDALTHA IEGLITKGAW EMSDMFEIKA IEMINRYLVT AVEEPSNAEA
     RNGMAVAQYI AGMAFSNVGL GVVHGMAHPL GAIFDIPHGV ANALLLPIIM EFNAPAALDK
     YVEIAKAMNV YSTDMTKEKA AEAAVEAVKT LSLRVNIPQH LSDLGIQESD LDRLATAAFA
     DVCTPGNPRE VTKEIILDLY KKAL
//