##gff-version 3 Q5JRA6 UniProtKB Signal peptide 1 22 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Chain 23 1907 . . . ID=PRO_0000288998;Note=Transport and Golgi organization protein 1 homolog Q5JRA6 UniProtKB Topological domain 23 1144 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Intramembrane 1145 1165 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Topological domain 1166 1176 . . . Note=Lumenal;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Transmembrane 1177 1197 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Topological domain 1198 1907 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Domain 45 107 . . . Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 Q5JRA6 UniProtKB Region 155 258 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 314 378 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 390 601 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 659 918 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 1093 1121 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 1211 1650 . . . Note=Mediates interaction with MIA2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21525241;Dbxref=PMID:21525241 Q5JRA6 UniProtKB Region 1420 1443 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 1642 1907 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Region 1751 1907 . . . Note=Proline-rich domain (PRD)%3B mediates interaction with the COPII coat subunits SEC23A and SEC23B;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19269366,ECO:0000269|PubMed:27551091,ECO:0000269|PubMed:28442536;Dbxref=PMID:19269366,PMID:27551091,PMID:28442536 Q5JRA6 UniProtKB Region 1788 1847 . . . Note=SEC16A-interacting region (SIR)%3B required for its localization to endoplasmic reticulum exit sites and for its interaction with SEC16A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28442536;Dbxref=PMID:28442536 Q5JRA6 UniProtKB Coiled coil 471 531 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Coiled coil 1214 1396 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Coiled coil 1487 1639 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Compositional bias 155 178 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 179 201 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 234 245 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 246 256 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 317 327 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 337 364 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 407 419 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 453 463 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 470 483 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 495 506 . . . Note=Low complexity;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 511 521 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 555 567 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 584 595 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 671 693 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 701 711 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 721 735 . . . Note=Acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 771 780 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 810 832 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 846 863 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 874 884 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 1650 1667 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 1721 1732 . . . Note=Low complexity;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 1733 1747 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 1777 1809 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 1859 1875 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Compositional bias 1892 1907 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q5JRA6 UniProtKB Modified residue 226 226 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039 Q5JRA6 UniProtKB Modified residue 229 229 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26091039;Dbxref=PMID:26091039 Q5JRA6 UniProtKB Modified residue 727 727 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q5JRA6 UniProtKB Modified residue 876 876 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q5JRA6 UniProtKB Modified residue 1067 1067 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q5JRA6 UniProtKB Modified residue 1431 1431 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1666 1666 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1678 1678 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1706 1706 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:23186163,PMID:24275569 Q5JRA6 UniProtKB Modified residue 1727 1727 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1741 1741 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1745 1745 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21406692;Dbxref=PMID:21406692 Q5JRA6 UniProtKB Modified residue 1784 1784 . . . Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1892 1892 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8BI84 Q5JRA6 UniProtKB Modified residue 1906 1906 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:26091039,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:24275569,PMID:26091039 Q5JRA6 UniProtKB Glycosylation 246 246 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q5JRA6 UniProtKB Glycosylation 589 589 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19159218;Dbxref=PMID:19159218 Q5JRA6 UniProtKB Alternative sequence 1 1122 . . . ID=VSP_025860;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q5JRA6 UniProtKB Alternative sequence 493 500 . . . ID=VSP_025861;Note=In isoform 3. MTVHSSVH->FKTEPIKL;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 Q5JRA6 UniProtKB Alternative sequence 501 1907 . . . ID=VSP_025862;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:12975309;Dbxref=PMID:12975309 Q5JRA6 UniProtKB Alternative sequence 1123 1159 . . . ID=VSP_025863;Note=In isoform 4. IDANKQPETAAEEPASVTPLENAILLIYSFMFYLTKS->MDSVPATVPSIAATPGDPELVGPLSVLYAAFIAKLLE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q5JRA6 UniProtKB Alternative sequence 1304 1362 . . . ID=VSP_025864;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q5JRA6 UniProtKB Natural variant 482 482 . . . ID=VAR_032546;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12975309;Dbxref=dbSNP:rs2936053,PMID:12975309 Q5JRA6 UniProtKB Natural variant 605 605 . . . ID=VAR_032547;Note=K->R;Dbxref=dbSNP:rs2936052 Q5JRA6 UniProtKB Natural variant 881 881 . . . ID=VAR_032548;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9039502;Dbxref=dbSNP:rs2936051,PMID:9039502 Q5JRA6 UniProtKB Natural variant 1659 1659 . . . ID=VAR_032549;Note=G->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17857325,PMID:15489334 Q5JRA6 UniProtKB Natural variant 1723 1723 . . . ID=VAR_032550;Note=K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs17854428,PMID:15489334 Q5JRA6 UniProtKB Sequence conflict 46 46 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5JRA6 UniProtKB Sequence conflict 1032 1032 . . . Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5JRA6 UniProtKB Sequence conflict 1443 1443 . . . Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5JRA6 UniProtKB Sequence conflict 1754 1754 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q5JRA6 UniProtKB Beta strand 34 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 48 52 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 60 63 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 70 80 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 85 90 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 93 98 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Helix 99 101 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 102 108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Beta strand 113 116 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M Q5JRA6 UniProtKB Turn 119 122 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7R3M