ID   XKR3_HUMAN              Reviewed;         459 AA.
AC   Q5GH77; B2RPN1; Q52PG8; Q8N7E1;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   04-NOV-2026, entry version 125.
DE   RecName: Full=XK-related protein 3;
DE   AltName: Full=X Kell blood group-related 3;
DE   AltName: Full=XTES;
GN   Name=XKR3; Synonyms=XRG3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   VARIANTS LEU-255 AND ASN-442.
RC   TISSUE=Testis;
RX   PubMed=16431037; DOI=10.1016/j.gene.2005.10.037;
RA   Calenda G., Peng J., Redman C.M., Sha Q., Wu X., Lee S.;
RT   "Identification of two new members, XPLAC and XTES, of the XK family.";
RL   Gene 370:6-16(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-232; LEU-255 AND
RP   ASN-442.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly, if not exclusively, in
CC       testis. {ECO:0000269|PubMed:16431037}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY534240; AAT07089.1; -; mRNA.
DR   EMBL; AY989815; AAX86010.1; -; mRNA.
DR   EMBL; AK098608; BAC05352.1; -; mRNA.
DR   EMBL; BC137521; AAI37522.1; -; mRNA.
DR   EMBL; BC137522; AAI37523.1; -; mRNA.
DR   CCDS; CCDS42975.1; -.
DR   RefSeq; NP_001305180.1; NM_001318251.3.
DR   RefSeq; NP_001373884.1; NM_001386955.1.
DR   RefSeq; NP_001373885.1; NM_001386956.1.
DR   RefSeq; NP_001373886.1; NM_001386957.1.
DR   RefSeq; NP_787074.2; NM_175878.5.
DR   SMR; Q5GH77; -.
DR   BioGRID; 127266; 7.
DR   STRING; 9606.ENSP00000331704; -.
DR   TCDB; 2.A.112.1.7; the kx blood-group antigen (kxa) family.
DR   iPTMnet; Q5GH77; -.
DR   PhosphoSitePlus; Q5GH77; -.
DR   BioMuta; XKR3; -.
DR   DMDM; 74707819; -.
DR   PaxDb; 9606-ENSP00000331704; -.
DR   PeptideAtlas; Q5GH77; -.
DR   ProteomicsDB; 62835; -.
DR   jPOST; Q5GH77; -.
DR   MassIVE; Q5GH77; -.
DR   DNASU; 150165; -.
DR   Ensembl; ENST00000331428.5; ENSP00000331704.5; ENSG00000172967.8.
DR   Ensembl; ENST00000684488.1; ENSP00000507478.1; ENSG00000172967.8.
DR   GeneID; 150165; -.
DR   KEGG; hsa:150165; -.
DR   MANE-Select; ENST00000684488.1; ENSP00000507478.1; NM_001386955.1; NP_001373884.1.
DR   UCSC; uc002zlv.4; human.
DR   CTD; 150165; -.
DR   DisGeNET; 150165; -.
DR   VEuPathDB; HostDB:ENSG00000172967; -.
DR   GeneCards; XKR3; -.
DR   HGNC; HGNC:28778; XKR3.
DR   AGR; HGNC:28778; -.
DR   HPA; ENSG00000172967; Tissue enriched (testis).
DR   MIM; 611674; gene.
DR   OpenTargets; ENSG00000172967; -.
DR   ClinPGx; PA142670562; -.
DR   eggNOG; ENOG502QSH6; Eukaryota.
DR   GeneTree; ENSGT00390000003231; -.
DR   HOGENOM; CLU_037429_1_1_1; -.
DR   InParanoid; Q5GH77; -.
DR   OMA; AAIEFCC; -.
DR   OrthoDB; 10037417at2759; -.
DR   PhylomeDB; Q5GH77; -.
DR   ChiTaRS; XKR3; human.
DR   Agora; ENSG00000172967; -.
DR   GenomeRNAi; 150165; -.
DR   PRO; PR:Q5GH77; -.
DR   Bgee; ENSG00000172967; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 16 other cell types or tissues.
DR   InterPro; IPR018629; XK-rel.
DR   InterPro; IPR051773; XK-related_adapter.
DR   PANTHER; PTHR14297; MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER; 1.
DR   PANTHER; PTHR14297:SF9; XK-RELATED PROTEIN 3; 1.
DR   Pfam; PF09815; XK-related; 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Proteomes; UP000005640; Chromosome 22.
DR   PathwayCommons; Q5GH77; -.
DR   Pharos; Q5GH77; Tbio.
DR   Antibodypedia; 22625; 79 antibodies from 18 providers.
DR   RNAct; Q5GH77; protein.
DR   BioGRID-ORCS; 150165; 21 hits in 1146 CRISPR screens.
DR   AlphaFoldDB; Q5GH77; -.
DR   PAN-GO; Q5GH77; 0 GO annotations based on evolutionary models.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Proteomics identification; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..459
FT                   /note="XK-related protein 3"
FT                   /id="PRO_0000190776"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         143
FT                   /note="T -> M (in dbSNP:rs5748648)"
FT                   /id="VAR_053740"
FT   VARIANT         232
FT                   /note="P -> L (in dbSNP:rs9605146)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_053741"
FT   VARIANT         255
FT                   /note="F -> L (in dbSNP:rs5748623)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:16431037"
FT                   /id="VAR_053742"
FT   VARIANT         442
FT                   /note="H -> N (in dbSNP:rs5748622)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:16431037"
FT                   /id="VAR_053743"
SQ   SEQUENCE   459 AA;  53448 MW;  291FDD2A952F6BD8 CRC64;
     METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF GLYMFEIYRK
     ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL FWHILLLGPI VRCLHTIRNY
     HKWLKNLKQE KEETQVSITK RNTMLEREIA FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI
     LQMYISLTIR EWPLNRALLM TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM
     WRFLEVISRV VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM
     VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF QFLENVIMIL
     VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL YPWQSGKVLP GRTENQPEAP
     YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF SIRKSMTCS
//