ID   XKR6_HUMAN              Reviewed;         641 AA.
AC   Q5GH73; Q8TBA0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   04-NOV-2026, entry version 143.
DE   RecName: Full=XK-related protein 6 {ECO:0000305};
GN   Name=XKR6 {ECO:0000312|HGNC:HGNC:27806};
GN   Synonyms=C8orf21 {ECO:0000312|HGNC:HGNC:27806}, C8orf5
GN   {ECO:0000312|HGNC:HGNC:27806}, C8orf7 {ECO:0000312|HGNC:HGNC:27806},
GN   XRG6 {ECO:0000303|Ref.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q6C8};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5GH73-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5GH73-2; Sequence=VSP_014663;
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY534244; AAT07093.1; -; mRNA.
DR   EMBL; BC024146; AAH24146.1; -; mRNA.
DR   CCDS; CCDS5978.2; -. [Q5GH73-1]
DR   RefSeq; NP_775954.2; NM_173683.4. [Q5GH73-1]
DR   AlphaFoldDB; Q5GH73; -.
DR   SMR; Q5GH73; -.
DR   BioGRID; 130280; 9.
DR   FunCoup; Q5GH73; 596.
DR   IntAct; Q5GH73; 5.
DR   NDEx; IQUERY-CP-XKR6; 1 NDEx IQuery Curated Pathway.
DR   STRING; 9606.ENSP00000416707; -.
DR   GlyGen; Q5GH73; 2 sites.
DR   iPTMnet; Q5GH73; -.
DR   PhosphoSitePlus; Q5GH73; -.
DR   BioMuta; XKR6; -.
DR   DMDM; 71153416; -.
DR   MassIVE; Q5GH73; -.
DR   PaxDb; 9606-ENSP00000416707; -.
DR   PeptideAtlas; Q5GH73; -.
DR   ProteomicsDB; 62832; -. [Q5GH73-1]
DR   ProteomicsDB; 62833; -. [Q5GH73-2]
DR   Antibodypedia; 8456; 49 antibodies from 15 providers.
DR   DNASU; 286046; -.
DR   Ensembl; ENST00000416569.3; ENSP00000416707.2; ENSG00000171044.11. [Q5GH73-1]
DR   GeneID; 286046; -.
DR   KEGG; hsa:286046; -.
DR   MANE-Select; ENST00000416569.3; ENSP00000416707.2; NM_173683.4; NP_775954.2.
DR   UCSC; uc003wtk.3; human. [Q5GH73-1]
DR   AGR; HGNC:27806; -.
DR   ClinPGx; PA134922549; -.
DR   CTD; 286046; -.
DR   DisGeNET; 286046; -.
DR   GeneCards; XKR6; -.
DR   HGNC; HGNC:27806; XKR6.
DR   HPA; ENSG00000171044; Low tissue specificity.
DR   OpenTargets; ENSG00000171044; -.
DR   VEuPathDB; HostDB:ENSG00000171044; -.
DR   eggNOG; KOG4790; Eukaryota.
DR   GeneTree; ENSGT01160000290782; -.
DR   HOGENOM; CLU_028534_1_0_1; -.
DR   InParanoid; Q5GH73; -.
DR   OMA; ACMIIYY; -.
DR   OrthoDB; 6356248at2759; -.
DR   PAN-GO; Q5GH73; 4 GO annotations based on evolutionary models.
DR   PhylomeDB; Q5GH73; -.
DR   PathwayCommons; Q5GH73; -.
DR   SignaLink; Q5GH73; -.
DR   Agora; ENSG00000171044; -.
DR   BioGRID-ORCS; 286046; 14 hits in 1144 CRISPR screens.
DR   ChiTaRS; XKR6; human.
DR   GenomeRNAi; 286046; -.
DR   Pharos; Q5GH73; Tdark.
DR   PRO; PR:Q5GH73; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q5GH73; protein.
DR   Bgee; ENSG00000171044; Expressed in buccal mucosa cell and 107 other cell types or tissues.
DR   ExpressionAtlas; Q5GH73; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR   InterPro; IPR018629; XK-rel.
DR   InterPro; IPR050895; XK-related_scramblase.
DR   InterPro; IPR061936; XKR4/6/7_C.
DR   PANTHER; PTHR16024; XK-RELATED PROTEIN; 1.
DR   PANTHER; PTHR16024:SF9; XK-RELATED PROTEIN 6; 1.
DR   Pfam; PF09815; XK-related; 1.
DR   Pfam; PF31027; XKR4_C; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Membrane; Proteomics identification;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..641
FT                   /note="XK-related protein 6"
FT                   /id="PRO_0000190785"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        442..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          20..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..46
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..120
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..279
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_014663"
SQ   SEQUENCE   641 AA;  71638 MW;  DEFFE0EE7CB43C79 CRC64;
     MAAKSDGGGV GVGFAQLHNL DEAVGSGGEE DGEPGGGGCG GGGDGSEPGE SSSMHICHCC
     NTSSCYWGCR SACLRSLLGR KPRRSAAADG GDQPLQPPAA PGAGRQPPTP SAARPEPPPP
     QVERPWLDCL WIVLALLVFF GDVGTDLWLA LDYYRKGDYV YFGLTLFFVL VPSLLVQSLS
     FRWFVQDYTG GGLGAVEGLT SRGPPMMGAG YVHGAARGGP GVRVSPTPGA QRLCRLSVWI
     WQSVIHLLQM GQVWRYIRTM YLGIQSQRRK EHQRRFYWAM MYEYADVNML RLLETFLESA
     PQLVLQLYIM LQKNSAETLP CVSSVTSLMS LAWVLASYHK LLRDSRDDKK SMSYRGAIIQ
     VFWRLFTISS RVISFALFAS IFQLYFGIFV VVHWCAMAFW IIHGGTDFCM SKWEEILFNM
     VVGIVYIFCW FNVKEGRTRY RMFAYYTIVL TENAALTFLW YFYRDPETTD SYAVPALCCV
     FISFVAGIAM MLLYYGVLHP TGPRAKILAS SCCAELLWGI PLPPDVEPMA PEIPGYRGTQ
     VTPTRAVTEQ QEDLTADTCL PVFQVRPMGP PTPLGRPYLP EGPLIKIDMP RKRYPAWDAH
     FVDRRLRRTI NILQYVTPTA VGIRYRDGPL LYELLQYESS L
//