ID NAR1_CANAL Reviewed; 607 AA. AC Q5APK7; A0A1D8PEJ3; DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot. DT 10-MAY-2017, sequence version 2. DT 02-SEP-2026, entry version 99. DE RecName: Full=Cytosolic Fe-S cluster assembly factor NAR1; DE AltName: Full=Nuclear architecture-related protein 1; GN Name=NAR1; OrderedLocusNames=CAALFM_C109010WA; GN ORFNames=CaO19.12221, CaO19.4757; OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes; OC Debaryomycetaceae; Candida/Lodderomyces clade; Candida. OX NCBI_TaxID=237561; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=15123810; DOI=10.1073/pnas.0401648101; RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., RA Scherer S.; RT "The diploid genome sequence of Candida albicans."; RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004). RN [2] RP GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52; RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D., RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M., RA Chibana H., Nantel A., Magee P.T.; RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned RT on the eight chromosomes."; RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION. RC STRAIN=SC5314 / ATCC MYA-2876; RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97; RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.; RT "Assembly of a phased diploid Candida albicans genome facilitates allele- RT specific measurements and provides a simple model for repeat and indel RT structure."; RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013). CC -!- FUNCTION: Component of the cytosolic Fe/S protein assembly machinery. CC Required for maturation of extramitochondrial Fe/S proteins. May play a CC role in the transfer of pre-assembled Fe/S clusters to target CC apoproteins (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the NARF family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP017623; AOW26536.1; -; Genomic_DNA. DR RefSeq; XP_723443.2; XM_718350.2. DR AlphaFoldDB; Q5APK7; -. DR SMR; Q5APK7; -. DR FunCoup; Q5APK7; 392. DR STRING; 237561.Q5APK7; -. DR PaxDb; 237561-Q5APK7; -. DR PeptideAtlas; Q5APK7; -. DR EnsemblFungi; C1_09010W_A-T; C1_09010W_A-T-p1; C1_09010W_A. DR GeneID; 3634916; -. DR KEGG; cal:CAALFM_C109010WA; -. DR CGD; CAL0000185143; NAR1. DR VEuPathDB; FungiDB:C1_09010W_A; -. DR eggNOG; KOG2439; Eukaryota. DR HOGENOM; CLU_018240_0_1_1; -. DR InParanoid; Q5APK7; -. DR OrthoDB; 10253113at2759; -. DR PRO; PR:Q5APK7; -. DR Proteomes; UP000000559; Chromosome 1. DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi. DR GO; GO:0097361; C:cytosolic [4Fe-4S] assembly targeting complex; IBA:GO_Central. DR GO; GO:0016020; C:membrane; IEA:EnsemblFungi. DR GO; GO:0051536; F:iron-sulfur cluster binding; ISS:UniProtKB. DR GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB. DR Gene3D; 3.30.70.20; -; 1. DR Gene3D; 3.40.50.1780; -; 1. DR Gene3D; 3.40.950.10; Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3; 1. DR InterPro; IPR050340; Cytosolic_Fe-S_CAF. DR InterPro; IPR009016; Fe_hydrogenase. DR InterPro; IPR004108; Fe_hydrogenase_lsu_C. DR PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1. DR Pfam; PF02906; Fe_hyd_lg_C; 1. DR SUPFAM; SSF53920; Fe-only hydrogenase; 1. PE 3: Inferred from homology; KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding; Reference proteome. FT CHAIN 1..607 FT /note="Cytosolic Fe-S cluster assembly factor NAR1" FT /id="PRO_0000383721" FT REGION 430..476 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 432..447 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 20 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="1" FT /evidence="ECO:0000255" FT BINDING 82 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="1" FT /evidence="ECO:0000255" FT BINDING 85 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="1" FT /evidence="ECO:0000255" FT BINDING 88 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="1" FT /evidence="ECO:0000255" FT BINDING 204 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="2" FT /evidence="ECO:0000255" FT BINDING 259 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="2" FT /evidence="ECO:0000255" FT BINDING 496 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="2" FT /evidence="ECO:0000255" FT BINDING 500 FT /ligand="[4Fe-4S] cluster" FT /ligand_id="ChEBI:CHEBI:49883" FT /ligand_label="2" FT /evidence="ECO:0000255" SQ SEQUENCE 607 AA; 67085 MW; 1532950F0CBA38EA CRC64; MSALLSADDL NDFISPGVAC IKPLASSSTN TTTTNTTDSY NENGEVEIQI DSQGNPLEIS KIDDKQFQTN KLTPAQISLA DCLACSGCIT SAEEVLVAQH SHQELIKALQ SQKETNKVFV VSISHQSRAS LAMAYNVSIE NMDKCLIDLF IRQMGFTYIV GTSLGRKLSL INEAKEIINR KTKGSGTGGI DSDSSSGPIL SSICPGWVLY AEKTHPYIIP KMSTVKSPQQ ITGCLLKNLT SNSLNIEKSK IYHLSIMPCF DKKLESARPE VYEEEEEEEE EKDKALVSVP DVDCVITAKE LITLLEECPQ YQLIPPTLPQ EELIGGGCLS MTEIYKQYAP PNWPFIEISW SNDSGSASGG YAYNYLTIYR NDLILKGYDG NKFTINLING RNPDIYEMRL MYNGENKEKL ASAAVVNGFR NIQNLVRKLK PNTGKSTNTT TTTTKSKVNP LAARRRARIA NNRGKPETKS TSEVNSQEME IVADASKVDY VEIMACPNGC INGGGQISAP NTTTTSITLP QKEIEKQWIN AVLEKYNSIP MFDLSSQSSS SSSPNEIIKF IEWSKKFENQ FNISDNRLFK THFNPVEKNI IMSVDDPATA LLVGSKW //