ID   ARP6_CANAL              Reviewed;         446 AA.
AC   Q5AP59; A0A1D8PET8;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   02-SEP-2026, entry version 111.
DE   RecName: Full=Actin-like protein ARP6;
GN   Name=ARP6; OrderedLocusNames=CAALFM_C110330CA;
GN   ORFNames=CaO19.12369, CaO19.4904;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC   Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
CC       dependent exchange of histone H2A for the H2A variant HZT1 leading to
CC       transcriptional regulation of selected genes by chromatin remodeling.
CC       Involved in chromosome stability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SWR1 chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the actin family. ARP6 subfamily. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26663.1; -; Genomic_DNA.
DR   RefSeq; XP_723586.1; XM_718493.1.
DR   AlphaFoldDB; Q5AP59; -.
DR   SMR; Q5AP59; -.
DR   FunCoup; Q5AP59; 338.
DR   STRING; 237561.Q5AP59; -.
DR   PaxDb; 237561-Q5AP59; -.
DR   EnsemblFungi; C1_10330C_A-T; C1_10330C_A-T-p1; C1_10330C_A.
DR   GeneID; 3634908; -.
DR   KEGG; cal:CAALFM_C110330CA; -.
DR   CGD; CAL0000174064; orf19.12369.
DR   VEuPathDB; FungiDB:C1_10330C_A; -.
DR   eggNOG; KOG0680; Eukaryota.
DR   HOGENOM; CLU_027965_1_1_1; -.
DR   InParanoid; Q5AP59; -.
DR   OMA; FFEEYEC; -.
DR   OrthoDB; 6220758at2759; -.
DR   PRO; PR:Q5AP59; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR   CDD; cd10210; ASKHA_NBD_Arp6; 1.
DR   FunFam; 3.90.640.10:FF:000040; Actin-like protein ARP6; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 3.90.640.10; Actin, Chain A, domain 4; 1.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; ACTIN; 1.
DR   Pfam; PF00022; Actin; 1.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   3: Inferred from homology;
KW   Activator; Chromatin regulator; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..446
FT                   /note="Actin-like protein ARP6"
FT                   /id="PRO_0000089112"
FT   REGION          99..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..112
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  50916 MW;  993B4B11B09513CB CRC64;
     MPEQLQKLVI DNGSYTIKAG FNTGDDDGND TSTPIKVTNA ISKTKDGIIH VGNQYLSHTN
     NFSGIQFRRP FEQNNLTSWE TEKPIWDYTL DNLLLQTNDQ SQSTSSSSSS SLQKHKRGKV
     IDPDDIHLIL TEQPYQLPQL STNTDQIIFE EYGFNKYYRC IAPSLVPFSV DTNQINDDFV
     LVIDSGFNST WIVPMIYQQI HWPAVKKLPI GGNLLNGLLR EMISFRHYDI SEDPILINTI
     KESTCFISSS NYQQDLQHKH DLMCEFVLPD FKLTITGFVK NENSMSSQKL PNDTQVLKLY
     DERFTVPETY FHPEIIFDNN RTTASSSLLN NAPFKNLTDL IVESIMACPS ITQPLLSANI
     CLSGGSTNIP NFKTRLIGEL RKELPSNWKV NIFDKQYDIN RDELSWYGGI NLSNESELLQ
     EISISKKDYF EHGANWCQQQ FGFKNV
//