ID   Q59GH5_HUMAN            Unreviewed;       276 AA.
AC   Q59GH5;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   02-SEP-2026, entry version 77.
DE   RecName: Full=COP9 signalosome complex subunit 5 {ECO:0000256|ARBA:ARBA00014880};
DE   AltName: Full=Jun activation domain-binding protein 1 {ECO:0000256|ARBA:ARBA00076748};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92371.1};
RN   [1] {ECO:0000313|EMBL:BAD92371.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92371.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|ARBA:ARBA00001968};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the peptidase M67A family. CSN5 subfamily.
CC       {ECO:0000256|ARBA:ARBA00006008}.
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DR   EMBL; AB209134; BAD92371.1; -; mRNA.
DR   AlphaFoldDB; Q59GH5; -.
DR   MEROPS; M67.002; -.
DR   PeptideAtlas; Q59GH5; -.
DR   GO; GO:0008180; C:COP9 signalosome; IEA:UniProtKB-ARBA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:UniProtKB-ARBA.
DR   CDD; cd08069; MPN_RPN11_CSN5; 1.
DR   FunFam; 3.40.140.10:FF:000203; COP9 signalosome complex subunit 5; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   InterPro; IPR040961; CSN5_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR050242; JAMM_MPN+_peptidase_M67A.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED; 1.
DR   Pfam; PF18323; CSN5_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01182};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01182};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049, ECO:0000256|PROSITE-
KW   ProRule:PRU01182}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01182}; Signalosome {ECO:0000256|ARBA:ARBA00022790};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU01182}.
FT   DOMAIN          24..161
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   MOTIF           107..120
FT                   /note="JAMM motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01182"
FT   BINDING         107
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01182"
FT   BINDING         109
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01182"
FT   BINDING         120
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01182"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92371.1"
SQ   SEQUENCE   276 AA;  31259 MW;  1928491F16FC794E CRC64;
     NFTLYKEFNY IVILFCSHHY FKYCKISALA LLKMVMHARS GGNLEVMGLM LGKVDGETMI
     IMDSFALPVE GTETRVNAQA AAYEYMAAYI ENAKQVGRLE NAIGWYHSHP GYGCWLSGID
     VSTQMLNQQF QEPFVAVVID PTRTISAGKV NLGAFRTYPK GYKPPDEGPS EYQTIPLNKI
     EDFGVHCKQY YALEVSYFKS SLDRKLLELL WNKYWVNTLS SSSLLTNADY TTGQVFDLSE
     KLEQSEAQLG RGSFMLGLET HDRKSEDKLA KATRDR
//