ID Q59FS0_HUMAN Unreviewed; 967 AA. AC Q59FS0; DT 26-APR-2005, integrated into UniProtKB/TrEMBL. DT 26-APR-2005, sequence version 1. DT 02-SEP-2026, entry version 105. DE RecName: Full=General transcription factor II-I repeat domain-containing protein 1 {ECO:0000256|ARBA:ARBA00072433}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92626.1}; RN [1] {ECO:0000313|EMBL:BAD92626.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Brain {ECO:0000313|EMBL:BAD92626.1}; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., RA Ohara O., Nagase T., Kikuno R.F.; RT "Homo sapiens protein coding cDNA."; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: May be a transcription regulator involved in cell-cycle CC progression and skeletal muscle differentiation. May repress GTF2I CC transcriptional functions, by preventing its nuclear residency, or by CC inhibiting its transcriptional activation. May contribute to slow- CC twitch fiber type specificity during myogenesis and in regenerating CC muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds CC specifically and with high affinity to the EFG sequences derived from CC the early enhancer of HOXC8. {ECO:0000256|ARBA:ARBA00058906}. CC -!- SUBUNIT: Interacts with the retinoblastoma protein (RB1) via its C- CC terminus. {ECO:0000256|ARBA:ARBA00063804}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00484}. CC -!- SIMILARITY: Belongs to the TFII-I family. {ECO:0000256|PROSITE- CC ProRule:PRU00484}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB209389; BAD92626.1; -; mRNA. DR AlphaFoldDB; Q59FS0; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-ARBA. DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro. DR FunFam; 3.90.1460.10:FF:000002; General transcription factor II-I isoform 1; 1. DR FunFam; 3.90.1460.10:FF:000005; general transcription factor II-I repeat domain-containing protein 1; 1. DR FunFam; 3.90.1460.10:FF:000006; General transcription factor II-I repeat domain-containing protein 1; 1. DR FunFam; 3.90.1460.10:FF:000007; General transcription factor II-I repeat domain-containing protein 1; 1. DR FunFam; 3.90.1460.10:FF:000008; General transcription factor II-I repeat domain-containing protein 1; 1. DR Gene3D; 3.90.1460.10; GTF2I-like; 5. DR InterPro; IPR004212; GTF2I. DR InterPro; IPR036647; GTF2I-like_rpt_sf. DR InterPro; IPR016659; TF_II-I. DR PANTHER; PTHR46304; GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1; 1. DR PANTHER; PTHR46304:SF1; GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 1; 1. DR Pfam; PF02946; GTF2I; 5. DR PIRSF; PIRSF016441; TF_II-I; 1. DR SUPFAM; SSF117773; GTF2I-like repeat; 5. DR PROSITE; PS51139; GTF2I; 5. PE 2: Evidence at transcript level; KW Developmental protein {ECO:0000256|ARBA:ARBA00022473}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00484}; Isopeptide bond {ECO:0000256|ARBA:ARBA00022499}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00484}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE- KW ProRule:PRU00484}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|PROSITE-ProRule:PRU00484}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}. FT REPEAT 126..220 FT /note="GTF2I-like" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00484" FT REPEAT 349..443 FT /note="GTF2I-like" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00484" FT REPEAT 563..657 FT /note="GTF2I-like" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00484" FT REPEAT 688..782 FT /note="GTF2I-like" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00484" FT REPEAT 785..879 FT /note="GTF2I-like" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00484" FT REGION 103..124 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 237..257 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 475..499 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 884..920 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 103..113 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 902..915 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAD92626.1" SQ SEQUENCE 967 AA; 106680 MW; F5B74BAF487B83B2 CRC64; GTGDQATMAL LGKRCDVPTN GCGPDRWNSA FTRKDEIITS LVSALDSMCS ALSKLNAEVA CVAVHDESAF VVGTEKGRMF LNARKELQSD FLRFCRGPPW KDPEAEHPKK VQRGEGGGRS LPRSSLEHGS DVYLLRKMVE EVFDVLYSEA LGRASVVPLP YERLLREPGL LAVQGLPEGL AFRRPAEYDP KALMAILEHS HRIRFKLKRP LEDGGRDSKA LVELNGVSLI PKGSRDCGLH GQAPKVPPQD LPPTATSSSM ASFLYSTALP NHAIRELKQE APSCPLAPSD LGLSRPMPEP KATGAQDFSD CCGQKPTGPG GPLIQNVHAS KRILFSIVHD KSEKWDAFIK ETEDINTLRE CVQILFNSRY AEALGLDHMV PVPYRKIACD PEAVEIVGIP DKIPFKRPCT YGVPKLKRIL EERHSIHFII KRMFDERIFT GNKFTKDTTK LEPASPPEDT SAEVSRATVL DLAGNARSDK GSMSEDCGPG TSGELGGLRP IKIEPEDLDI IQVTVPDPSP TSEEMTDSMP GHLPSEDSGY GMEMLTDKGL SEDARPEERP VEDSHGDVIR PLRKQVELLF NTRYAKAIGI SEPVKVPYSK FLMHPEELFV VGLPEGISLR RPNCFGIAKL RKILEASNSI QFVIKRPELL TEGVKEPIMD SQERDSGDPL VDESLKRQGF QENYDARLSR IDIANTLREQ VQDLFNKKYG EALGIKYPVQ VPYKRIKSNP GSVIIEGLPP GIPFRKPCTF GSQNLERILA VADKIKFTVT RPFQGLIPKP DEDDANRLGE KVILREQVKE LFNEKYGEAL GLNRPVLVPY KLIRDSPDAV EVTGLPDDIP FRNPNTYDIH RLEKILKARE HVRMVIINQL QPFAEICNDA KVPAKDSSIP KRKRKRVSEG NSVSSSSSSS SSSSSNPDSV ASANQISLVV KLHRFGLRHS SLWPSPLCLA GPSTLGCGPR GRGGTGL //