ID   Q59FD0_HUMAN            Unreviewed;       449 AA.
AC   Q59FD0;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   10-JUN-2026, entry version 63.
DE   SubName: Full=Huntingtin interacting protein-1-related {ECO:0000313|EMBL:BAD92767.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92767.1};
RN   [1] {ECO:0000313|EMBL:BAD92767.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92767.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB209530; BAD92767.1; -; mRNA.
DR   AlphaFoldDB; Q59FD0; -.
DR   CAZy; GH89; Glycoside Hydrolase Family 89.
DR   PeptideAtlas; Q59FD0; -.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR   InterPro; IPR007781; NAGLU.
DR   InterPro; IPR024732; NAGLU_C.
DR   InterPro; IPR024733; NAGLU_tim-barrel.
DR   PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR   Pfam; PF05089; NAGLU; 1.
DR   Pfam; PF12972; NAGLU_C; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          8..141
FT                   /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF05089"
FT   DOMAIN          150..395
FT                   /note="Alpha-N-acetylglucosaminidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12972"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92767.1"
SQ   SEQUENCE   449 AA;  50312 MW;  BDCE35E5AC851B26 CRC64;
     PQCCLHSRGM FPRLSPVDTE AVWLLQGWLF QHQPQFWGPA QIRAVLGAVP RGRLLVLDLF
     AESQPVYTRT ASFQGQPFIW CMLHNFGGNH GLFGALEAVN GGPEAARLFP NSTMVGTGMA
     PEGISQNEVV YSLMAELGWR KDPVPDLAAW VTSFAARRYG VSHPDAGAAW RLLLRSVYNC
     SGEACRGHNR SPLVRRPSLQ MNTSIWYNRS DVFEAWRLLL TSAPSLATSP AFRYDLLDLT
     RQAVQELVSL YYEEARSAYL SKELASLLRA GGVLAYELLP ALDEVLASDS RFLLGSWLEQ
     ARAAAVSEAE ADFYEQNSRY QLTLWGPEGN ILDYANKQLA GLVANYYTPR WRLFLEALVD
     SVAQGIPFQQ HQFDKNVFQL EQAFVLSKQR YPSQHVVLLP QLPQPHAFSL QRLLQLQDTH
     LRLHLLLLQL DEGQAGEIHG VSVLNLLLA
//