ID   VAS1L_HUMAN             Reviewed;         224 AA.
AC   Q52LC2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   04-NOV-2026, entry version 136.
DE   RecName: Full=V-type proton ATPase subunit S1-like protein;
DE   AltName: Full=Vacuolar proton pump subunit S1-like protein;
GN   Name=ATP6AP1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the vacuolar ATPase subunit S1 family.
CC       {ECO:0000305}.
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DR   EMBL; CH471084; EAW95889.1; -; Genomic_DNA.
DR   EMBL; BC093982; AAH93982.1; -; mRNA.
DR   EMBL; BC112191; AAI12192.1; -; mRNA.
DR   AlphaFoldDB; Q52LC2; -.
DR   SMR; Q52LC2; -.
DR   FunCoup; Q52LC2; 10.
DR   STRING; 9606.ENSP00000391381; -.
DR   GlyGen; Q52LC2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q52LC2; -.
DR   PhosphoSitePlus; Q52LC2; -.
DR   BioMuta; ATP6AP1L; -.
DR   DMDM; 74735800; -.
DR   MassIVE; Q52LC2; -.
DR   PaxDb; 9606-ENSP00000391381; -.
DR   PeptideAtlas; Q52LC2; -.
DR   ProteomicsDB; 62421; -.
DR   DNASU; 92270; -.
DR   UCSC; uc003khv.5; human.
DR   AGR; HGNC:28091; -.
DR   ClinPGx; PA164716384; -.
DR   GeneCards; ATP6AP1L; -.
DR   HGNC; HGNC:28091; ATP6AP1L.
DR   VEuPathDB; HostDB:ENSG00000205464; -.
DR   eggNOG; KOG3868; Eukaryota.
DR   HOGENOM; CLU_071317_1_0_1; -.
DR   InParanoid; Q52LC2; -.
DR   OMA; AECYKLR; -.
DR   PAN-GO; Q52LC2; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; Q52LC2; -.
DR   PathwayCommons; Q52LC2; -.
DR   SignaLink; Q52LC2; -.
DR   BioGRID-ORCS; 92270; 19 hits in 1150 CRISPR screens.
DR   ChiTaRS; ATP6AP1L; human.
DR   GenomeRNAi; 92270; -.
DR   Pharos; Q52LC2; Tdark.
DR   PRO; PR:Q52LC2; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q52LC2; protein.
DR   GO; GO:0098588; C:bounding membrane of organelle; IEA:UniProtKB-ARBA.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-ARBA.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-ARBA.
DR   FunFam; 2.40.160.110:FF:000003; ATPase H+ transporting accessory protein 1; 1.
DR   Gene3D; 2.40.160.110; -; 1.
DR   InterPro; IPR008388; Ac45_acc_su.
DR   InterPro; IPR046756; VAS1/VOA1_TM.
DR   InterPro; IPR046755; VAS1_LD.
DR   PANTHER; PTHR12471:SF3; ATPASE, H+ TRANSPORTING, LYSOSOMAL ACCESSORY PROTEIN 1-LIKE; 1.
DR   PANTHER; PTHR12471; VACUOLAR ATP SYNTHASE SUBUNIT S1; 1.
DR   Pfam; PF20520; Ac45-VOA1_TM; 1.
DR   Pfam; PF05827; VAS1_LD; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..224
FT                   /note="V-type proton ATPase subunit S1-like protein"
FT                   /id="PRO_0000342377"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  25310 MW;  65C104B815443678 CRC64;
     MRLWKARVLK LVLKTAKDSR LGLNSKWLSL KLGDAGNPRS LAIRFILTNY NKLSIQSWFS
     LRRVEIISNN SIQAVFNPTG VYAPSGYSYR CQRVGSLQQD QALLLPSDTD DGSSLWEVTF
     IDFQIQGFAI KGGRFTKAQD CASSFSPAFL IGLAMSLILL LVLAYALHML IYLRYLDQQY
     DLIASPAHFS QLKARDTAEE KELLRSQGAE CYKLRSQQIS KIYV
//