ID   Q51162_NEIME            Unreviewed;       720 AA.
AC   Q51162;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   28-JAN-2026, entry version 124.
DE   SubName: Full=Fe-regulated protein B {ECO:0000313|EMBL:CAA61902.1};
GN   Name=frpB {ECO:0000313|EMBL:CAA61902.1};
OS   Neisseria meningitidis.
OC   Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=487 {ECO:0000313|EMBL:CAA61902.1};
RN   [1] {ECO:0000313|EMBL:CAA61902.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H44/76 {ECO:0000313|EMBL:CAA61902.1};
RX   PubMed=7558339;
RA   Pettersson A.M., Maas, van Wassenaar, van der Ley, Tommassen;
RT   "Molecular characterization of FrpB, the 70-kilodalton iron-regulated outer
RT   membrane protein of Neisseria meningitidis.";
RL   Infect. Immun. 63:4181-4184(1995).
RN   [2] {ECO:0007829|PDB:4AIP}
RP   X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 23-720 IN COMPLEX WITH
RP   L-GLUTAMATE.
RX   PubMed=23457610; DOI=10.1371/journal.pone.0056746;
RA   Saleem M., Prince S.M., Rigby S.E., Imran M., Patel H., Chan H.,
RA   Sanders H., Maiden M.C., Feavers I.M., Derrick J.P.;
RT   "Use of a molecular decoy to segregate transport from antigenicity in the
RT   FrpB iron transporter from Neisseria meningitidis.";
RL   PLoS ONE 8:e56746-e56746(2013).
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000256|ARBA:ARBA00004571, ECO:0000256|PROSITE-ProRule:PRU01360};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004571,
CC       ECO:0000256|PROSITE-ProRule:PRU01360}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000256|ARBA:ARBA00009810, ECO:0000256|PROSITE-ProRule:PRU01360,
CC       ECO:0000256|RuleBase:RU003357}.
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DR   EMBL; X89755; CAA61902.1; -; Genomic_DNA.
DR   PIR; S58133; S58133.
DR   RefSeq; WP_002244334.1; NZ_CP031330.1.
DR   PDB; 4AIP; X-ray; 2.40 A; A/B/C=23-720.
DR   AlphaFoldDB; Q51162; -.
DR   SMR; Q51162; -.
DR   EvolutionaryTrace; Q51162; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:TreeGrafter.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IEA:TreeGrafter.
DR   Gene3D; 2.40.170.20; TonB-dependent receptor, beta-barrel domain; 1.
DR   Gene3D; 2.170.130.10; TonB-dependent receptor, plug domain; 1.
DR   InterPro; IPR000531; Beta-barrel_TonB.
DR   InterPro; IPR036942; Beta-barrel_TonB_sf.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR039426; TonB-dep_rcpt-like.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   NCBIfam; TIGR01783; TonB-siderophor; 1.
DR   PANTHER; PTHR30069:SF41; HEME_HEMOPEXIN UTILIZATION PROTEIN C; 1.
DR   PANTHER; PTHR30069; TONB-DEPENDENT OUTER MEMBRANE RECEPTOR; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec_b-barrel; 1.
DR   SUPFAM; SSF56935; Porins; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
DR   PROSITE; PS52016; TONB_DEPENDENT_REC_3; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4AIP};
KW   Cell outer membrane {ECO:0000256|ARBA:ARBA00023237, ECO:0000256|PROSITE-
KW   ProRule:PRU01360}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01360}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   TonB box {ECO:0000256|ARBA:ARBA00023077, ECO:0000256|RuleBase:RU003357};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01360};
KW   Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452,
KW   ECO:0000256|PROSITE-ProRule:PRU01360};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW   ProRule:PRU01360}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..720
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004248336"
FT   DOMAIN          45..144
FT                   /note="TonB-dependent receptor plug"
FT                   /evidence="ECO:0000259|Pfam:PF07715"
FT   DOMAIN          277..689
FT                   /note="TonB-dependent receptor-like beta-barrel"
FT                   /evidence="ECO:0000259|Pfam:PF00593"
FT   MOTIF           703..720
FT                   /note="TonB C-terminal box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10144"
FT   BINDING         254
FT                   /ligand="L-glutamate"
FT                   /ligand_id="ChEBI:CHEBI:29985"
FT                   /evidence="ECO:0007829|PDB:4AIP"
SQ   SEQUENCE   720 AA;  79612 MW;  7F9E540A12A3DB2D CRC64;
     MNTPLFRLSL LSLTLAAGFA HAAENNAKVV LDTVTVKGDR QGSKIRTNIV TLQQKDESTA
     TDMRELLKEE PSIDFGGGNG TSQFLTLRGM GQNSVDIKVD NAYSDSQILY HQGRFIVDPA
     LVKVVSVQKG AGSASAGIGA TNGAIIAKTV DAQDLLKGLD KNWGVRLNSG FASNEGVSYG
     ASVFGKEGNF DGLFSYNRND EKDYEAGKGF RNVNGGKTVP YSALDKRSYL AKIGTTFGDD
     DHRIVLSHMK DQHRGIRTVR EEFTVGDKSS RINIDRQAPA YRETTQSNTN LAYTGKNLGF
     VEKLDANAYV LEKERYSADD SGTGYAGNVK GPNHTRITTR GANFNFDSRL AEQTLLKYGI
     NYRHQEIKPQ AFLNSKFSIP TTEEKNGQKV DKPMEQQMKD RADEDTVHAY KLSNPTKTDT
     GVYVEAIHDI GDFTLTGGLR YDRFKVKTHD GKTVSSSNLN PSFGVIWQPH EHWSFSASHN
     YASRSPRLYD ALQTHGKRGI ISIADGTKAE RARNTEIGFN YNDGTFAANG SYFWQTIKDA
     LANPQNRHDS VAVREAVNAG YIKNHGYELG ASYRTGGLTA KVGVSHSKPR FYDTHKDKLL
     SANPEFGAQV GRTWTASLAY RFQNPNLEIG WRGRYVQKAT GSILAAGQKD RKGNLENVVR
     KGFGVNDVFA NWKPLGKDTL NVNLSVNNVF NKFYYPHSQR WTNTLPGVGR DVRLGVNYKF
//