ID   UXUA_HAEI8              Reviewed;         394 AA.
AC   Q4QPI9;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   10-JUN-2026, entry version 99.
DE   RecName: Full=Mannonate dehydratase {ECO:0000255|HAMAP-Rule:MF_00106};
DE            EC=4.2.1.8 {ECO:0000255|HAMAP-Rule:MF_00106};
DE   AltName: Full=D-mannonate hydro-lyase {ECO:0000255|HAMAP-Rule:MF_00106};
GN   Name=uxuA {ECO:0000255|HAMAP-Rule:MF_00106};
GN   OrderedLocusNames=NTHI0065;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pasteurellales; Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=86-028NP;
RX   PubMed=15968074; DOI=10.1128/jb.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable Haemophilus
RT   influenzae: comparative study with H. influenzae serotype d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Catalyzes the dehydration of D-mannonate. {ECO:0000255|HAMAP-
CC       Rule:MF_00106}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O;
CC         Xref=Rhea:RHEA:20097, ChEBI:CHEBI:15377, ChEBI:CHEBI:17767,
CC         ChEBI:CHEBI:57990; EC=4.2.1.8; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00106};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00106}.
CC   -!- SIMILARITY: Belongs to the mannonate dehydratase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00106}.
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DR   EMBL; CP000057; AAX87058.1; -; Genomic_DNA.
DR   RefSeq; WP_011271799.1; NC_007146.2.
DR   AlphaFoldDB; Q4QPI9; -.
DR   SMR; Q4QPI9; -.
DR   GeneID; 93218931; -.
DR   KEGG; hit:NTHI0065; -.
DR   HOGENOM; CLU_058621_2_0_6; -.
DR   UniPathway; UPA00246; -.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:TreeGrafter.
DR   GO; GO:0030145; F:manganese ion binding; IEA:TreeGrafter.
DR   GO; GO:0008927; F:mannonate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042840; P:D-glucuronate catabolic process; IEA:TreeGrafter.
DR   FunFam; 3.20.20.150:FF:000004; Mannonate dehydratase; 1.
DR   FunFam; 3.20.20.150:FF:000005; Mannonate dehydratase; 1.
DR   Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 2.
DR   HAMAP; MF_00106; UxuA; 1.
DR   InterPro; IPR004628; Man_deHydtase.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   NCBIfam; NF003027; PRK03906.1; 1.
DR   NCBIfam; TIGR00695; uxuA; 1.
DR   PANTHER; PTHR30387; MANNONATE DEHYDRATASE; 1.
DR   PANTHER; PTHR30387:SF2; MANNONATE DEHYDRATASE; 1.
DR   Pfam; PF03786; UxuA; 1.
DR   PIRSF; PIRSF016049; Man_dehyd; 1.
DR   SUPFAM; SSF51658; Xylose isomerase-like; 1.
PE   3: Inferred from homology;
KW   Iron; Lyase; Manganese.
FT   CHAIN           1..394
FT                   /note="Mannonate dehydratase"
FT                   /id="PRO_0000231053"
SQ   SEQUENCE   394 AA;  45307 MW;  944B1515B026BF41 CRC64;
     MEQAWRWYGP KDPVSLSDIR QAGATGIVTA LHHIPNGEVW SIEEIKKRKT EIENAGLSWS
     VVESVPVHEE IKTQTGNYQK WINNYKQTLR NLAQCGIDTV CYNFMPVLDW TRTDLAYELP
     DGSKALRFDH IAFAAFELHI LKRPDAEKAY NQEEQVAART YYDKMSEQDI TQLTRNIIAG
     LPGAEEGYTL DEFQTQLDRY KDISPEKFRT HLAYFLNEIV PVAQEVGIKM AIHPDDPPRP
     ILGLPRIVST IEDMQWFVET QPLPANGFTM CTGSYGVRSD NDLVKMTEQF ADRIYFAHLR
     STQREDNPLT FHEAAHLEGD VDMFNVVKAL LNEEYRRLNQ GETRLIPMRP DHGHQMLDDL
     RKKTNPGYSA IGRLKGLAEF RGLEMALKKV YFNK
//