ID   SRPRB_RAT               Reviewed;         269 AA.
AC   Q4FZX7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   02-SEP-2026, entry version 105.
DE   RecName: Full=Signal recognition particle receptor subunit beta;
DE            Short=SR-beta;
GN   Name=Srprb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex
CC       receptor (SR) (By similarity). Ensures, in conjunction with the SRP
CC       complex, the correct targeting of the nascent secretory proteins to the
CC       endoplasmic reticulum membrane system (By similarity). May mediate the
CC       membrane association of SR (By similarity).
CC       {ECO:0000250|UniProtKB:P47758}.
CC   -!- SUBUNIT: Heterodimer with SRPRA. {ECO:0000250|UniProtKB:P47758}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:O13950}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SRP receptor beta subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BC098951; AAH98951.1; -; mRNA.
DR   RefSeq; NP_001013270.1; NM_001013252.1.
DR   AlphaFoldDB; Q4FZX7; -.
DR   SMR; Q4FZX7; -.
DR   BioGRID; 256772; 1.
DR   FunCoup; Q4FZX7; 2230.
DR   GlyGen; Q4FZX7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q4FZX7; -.
DR   PhosphoSitePlus; Q4FZX7; -.
DR   jPOST; Q4FZX7; -.
DR   GeneID; 300965; -.
DR   KEGG; rno:300965; -.
DR   UCSC; RGD:1304698; rat.
DR   AGR; RGD:1304698; -.
DR   CTD; 58477; -.
DR   RGD; 1304698; Srprb.
DR   InParanoid; Q4FZX7; -.
DR   OrthoDB; 41266at2759; -.
DR   PRO; PR:Q4FZX7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0005785; C:signal recognition particle receptor complex; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD.
DR   GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR   CDD; cd04105; SR_beta; 1.
DR   FunFam; 3.40.50.300:FF:001173; signal recognition particle receptor subunit beta; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR019009; SRP_receptor_beta_su.
DR   PANTHER; PTHR45909; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR   PANTHER; PTHR45909:SF1; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR   Pfam; PF09439; SRPRB; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding;
KW   Phosphoprotein; Receptor; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..269
FT                   /note="Signal recognition particle receptor subunit beta"
FT                   /id="PRO_0000331245"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         69..77
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         90..93
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         118
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         246
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         110
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5M8"
FT   MOD_RES         212
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5M8"
SQ   SEQUENCE   269 AA;  29569 MW;  DA63194232A47386 CRC64;
     MASANTRRVG DGAGGAFQPY LDSLRQELQQ RDPTLLSVAV AVLAVLLTLV FWKFIWSRKS
     SQRAVLFVGL CDSGKTLLFV RLLTGQYRDT QTSITDSSAI YKVNNNRGNS LTLIDLPGHE
     SLRLQFLDRF KSSARAVVFV VDSATFQREV KDVAEFLYQV LIDSMALKNT PAFLVACNKQ
     DIAMAKSAKL IQQQLEKELN TLRVTRSAAP STLDSSSTAP AQLGKKGKEF EFSQLPLKVE
     FLECSAKGGR GDAGSADVQD LEKWLAKIA
//