ID   Q4FP82_PELUB            Unreviewed;       190 AA.
AC   Q4FP82;
DT   30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2005, sequence version 1.
DT   04-NOV-2026, entry version 85.
DE   RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE            EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN   Name=tag {ECO:0000313|EMBL:AAZ21007.1};
GN   OrderedLocusNames=SAR11_0186 {ECO:0000313|EMBL:AAZ21007.1};
OS   Pelagibacter ubique (strain HTCC1062).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Alphaproteobacteria;
OC   Candidatus Pelagibacterales; Candidatus Pelagibacteraceae;
OC   Candidatus Pelagibacter.
OX   NCBI_TaxID=335992 {ECO:0000313|EMBL:AAZ21007.1, ECO:0000313|Proteomes:UP000002528};
RN   [1] {ECO:0000313|EMBL:AAZ21007.1, ECO:0000313|Proteomes:UP000002528}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC1062 {ECO:0000313|EMBL:AAZ21007.1,
RC   ECO:0000313|Proteomes:UP000002528};
RX   PubMed=16109880; DOI=10.1126/science.1114057;
RA   Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D.,
RA   Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M.,
RA   Carrington J.C., Mathur E.J.;
RT   "Genome streamlining in a cosmopolitan oceanic bacterium.";
RL   Science 309:1242-1245(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC         methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00000086};
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DR   EMBL; CP000084; AAZ21007.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4FP82; -.
DR   STRING; 335992.SAR11_0186; -.
DR   KEGG; pub:SAR11_0186; -.
DR   eggNOG; COG0122; Bacteria.
DR   HOGENOM; CLU_000445_72_5_5; -.
DR   OMA; AAAHLWW; -.
DR   Proteomes; UP000002528; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0032993; C:protein-DNA complex; IEA:TreeGrafter.
DR   GO; GO:0032131; F:alkylated DNA binding; IEA:TreeGrafter.
DR   GO; GO:0008725; F:DNA-3-methyladenine glycosylase activity; IEA:TreeGrafter.
DR   GO; GO:0043916; F:DNA-7-methylguanine glycosylase activity; IEA:TreeGrafter.
DR   GO; GO:0006285; P:base-excision repair, AP site formation; IEA:TreeGrafter.
DR   GO; GO:0006307; P:DNA alkylation repair; IEA:TreeGrafter.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.40; -; 1.
DR   Gene3D; 1.10.340.30; Hypothetical protein, domain 2; 1.
DR   InterPro; IPR051912; Alkylbase_DNA_Glycosylase/TA.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR   PANTHER; PTHR43003:SF5; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SUPFAM; SSF48150; DNA-glycosylase; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Glycosidase {ECO:0000313|EMBL:AAZ21007.1};
KW   Hydrolase {ECO:0000313|EMBL:AAZ21007.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002528}.
FT   DOMAIN          31..184
FT                   /note="HhH-GPD"
FT                   /evidence="ECO:0000259|SMART:SM00478"
SQ   SEQUENCE   190 AA;  21781 MW;  9B2E459B8C5DC62D CRC64;
     MSSLINKYKS PSEAVLTSRK DIFFSLCKSI IGQQISVAAA NSVFLKFKKK CKNKINAKTV
     SKLSSVQLKS CGLSGQKVRG IKSLAKQILD KSFNPRLIPK MSDEEAIIYL SQLRQIGRWS
     AEMILLFTYN RSNIWPIQDI GLLRGISKNY KKKYLPPESY VKLLNKRFSP YCSVATWYLW
     RSIDPEPIQY
//