ID   Q49ME5_AMBTI            Unreviewed;       240 AA.
AC   Q49ME5;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   04-NOV-2026, entry version 67.
DE   RecName: Full=Fucosyltransferase {ECO:0000256|RuleBase:RU003832};
DE            EC=2.4.1.- {ECO:0000256|RuleBase:RU003832};
DE   Flags: Fragment;
OS   Ambystoma tigrinum (Eastern tiger salamander).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX   NCBI_TaxID=8305 {ECO:0000313|EMBL:AAW32623.1};
RN   [1] {ECO:0000313|EMBL:AAW32623.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Petit D.P., Petit J.-M.;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAW32623.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16927008; DOI=10.1007/s00239-005-0189-x;
RA   Petit D., Maftah A., Julien R., Petit J.M.;
RT   "En bloc duplications, mutation rates, and densities of amino acid changes
RT   clarify the evolution of vertebrate alpha-1,3/4-fucosyltransferases.";
RL   J. Mol. Evol. 63:353-364(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-
CC         N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an
CC         alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-
CC         GlcNAc derivative + GDP + H(+); Xref=Rhea:RHEA:56076,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57273, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:136545, ChEBI:CHEBI:139509;
CC         Evidence={ECO:0000256|ARBA:ARBA00036481};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:56077;
CC         Evidence={ECO:0000256|ARBA:ARBA00036481};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|ARBA:ARBA00004922}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000256|RuleBase:RU003832}; Single-pass type II membrane protein
CC       {ECO:0000256|RuleBase:RU003832}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 10 family.
CC       {ECO:0000256|ARBA:ARBA00008919, ECO:0000256|RuleBase:RU003832}.
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DR   EMBL; AY692027; AAW32623.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q49ME5; -.
DR   BRENDA; 2.4.1.152; 295.
DR   UniPathway; UPA00378; -.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046920; F:alpha-(1->3)-fucosyltransferase activity; IEA:TreeGrafter.
DR   GO; GO:0009101; P:glycoprotein biosynthetic process; IEA:InterPro.
DR   FunFam; 3.40.50.11660:FF:000001; alpha-(1,3)-fucosyltransferase 9; 1.
DR   Gene3D; 3.40.50.11660; Glycosyl transferase family 10, C-terminal domain; 1.
DR   InterPro; IPR055270; Glyco_tran_10_C.
DR   InterPro; IPR031481; Glyco_tran_10_N.
DR   InterPro; IPR001503; Glyco_trans_10.
DR   InterPro; IPR038577; GT10-like_C_sf.
DR   PANTHER; PTHR11929; ALPHA- 1,3 -FUCOSYLTRANSFERASE; 1.
DR   PANTHER; PTHR11929:SF244; FUCOSYLTRANSFERASE; 1.
DR   Pfam; PF17039; Glyco_tran_10_N; 1.
DR   Pfam; PF00852; Glyco_transf_10; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU003832};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU003832};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transferase {ECO:0000256|RuleBase:RU003832, ECO:0000313|EMBL:AAW32623.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003832};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          7..113
FT                   /note="Fucosyltransferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17039"
FT   DOMAIN          127..240
FT                   /note="Fucosyltransferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00852"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAW32623.1"
FT   NON_TER         240
FT                   /evidence="ECO:0000313|EMBL:AAW32623.1"
SQ   SEQUENCE   240 AA;  27945 MW;  B9742A568E76FB24 CRC64;
     SKPEEPVKII LLWTWPFGFA FPLNQCPSQF NGTGCFFTAN RSLYSEAAAV VLHSRDVCSS
     KNQLPQMQRP PNQYWIWFTL ESPSHNYNTS FVEKLINLTM TYRADSDIFT PYGWLERHDG
     TENVSIPEKT KLVAWVVSNW NPNSRRVEYY GELKNHLAVD VFGNQRLQLP RDKHIETLPK
     YKFYLAFENS IHEDYITEKL WHNALASWAV PVVLGPTRAN YERFLPPDAF IHVDDFPTAK
//