ID   Q3SWS4_MOUSE            Unreviewed;       334 AA.
AC   Q3SWS4;
DT   11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2005, sequence version 1.
DT   02-SEP-2026, entry version 142.
DE   RecName: Full=Vasopressin V2 receptor {ECO:0000256|ARBA:ARBA00014011, ECO:0000256|RuleBase:RU046427};
GN   Name=Avpr2 {ECO:0000313|EMBL:AAI04729.1, ECO:0000313|MGI:MGI:88123};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI04729.1};
RN   [1] {ECO:0000313|EMBL:AAI04729.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones {ECO:0000313|EMBL:AAI04729.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: G protein-coupled receptor for arginine vasopressin, an
CC       antidiuretic that promotes renal water reabsorption. Ligand binding
CC       causes a conformation change that triggers signaling via guanine
CC       nucleotide-binding proteins (G proteins) and modulates the activity of
CC       downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is
CC       coupled to G(s) G alpha proteins and mediates activation of adenylate
CC       cyclase activity. {ECO:0000256|ARBA:ARBA00095923,
CC       ECO:0000256|RuleBase:RU046427}.
CC   -!- SUBUNIT: Interacts with ARRDC4. Identified in a complex containing at
CC       least ARRDC4, V2R and HGS. Interacts with TMEM147. Interacts (when
CC       phosphorylated) with ARRB2; the interaction is associated with
CC       internalization of the receptor and short-term desensitization to the
CC       ligand. {ECO:0000256|ARBA:ARBA00094671}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU046427}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU046427}.
CC   -!- SIMILARITY: Belongs to the G protein-coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily.
CC       {ECO:0000256|RuleBase:RU046427}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00521,
CC       ECO:0000256|RuleBase:RU046427}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC104728; AAI04729.1; -; mRNA.
DR   RefSeq; NP_001263227.1; NM_001276298.1.
DR   AlphaFoldDB; Q3SWS4; -.
DR   SMR; Q3SWS4; -.
DR   Antibodypedia; 17443; 298 antibodies from 34 providers.
DR   DNASU; 12000; -.
DR   GeneID; 12000; -.
DR   UCSC; uc009tmz.2; mouse.
DR   AGR; MGI:88123; -.
DR   CTD; 554; -.
DR   MGI; MGI:88123; Avpr2.
DR   VEuPathDB; HostDB:ENSMUSG00000031390; -.
DR   GeneTree; ENSGT01050000244882; -.
DR   OrthoDB; 5987909at2759; -.
DR   BioGRID-ORCS; 12000; 2 hits in 78 CRISPR screens.
DR   Bgee; ENSMUSG00000031390; Expressed in right kidney and 43 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:UniProtKB-UniRule.
DR   FunFam; 1.20.1070.10:FF:000190; Vasopressin V2 receptor; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR000161; Vprsn_rcpt_V2.
DR   PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24241:SF20; VASOPRESSIN V2 RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00898; VASOPRSNV2R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   G protein-coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW   ECO:0000256|PROSITE-ProRule:PRU00521};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU046427};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00521}; Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PROSITE-
KW   ProRule:PRU00521};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW   ProRule:PRU00521};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU046427};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU046427}.
FT   TRANSMEM        38..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        74..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        113..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        155..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   TRANSMEM        204..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU046427"
FT   DOMAIN          53..231
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..23
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  36203 MW;  C6056A7180116627 CRC64;
     MILVSTTSVP GALSSPSSPS NSSQEELLDD RDPLLVRAEL ALLSTIFVAV ALSNGLVLGA
     LIRRGRRGRW APMHVFISHL CLADLAVALF QVLPQLAWDA TDRFHGPDAL CRAVKYLQMV
     GMYASSYMIL AMTLDRHRAI CRPMLAYRHG GGARWNRPVL VAWAFSLLLS LPQLFIFAQR
     DVGNGSGVFD CWARFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHASLVPGPS
     ERAGRRRRGH RTGSPSEGAH VSAAMAKTVR MTLDPPLCCS CCWLALTAVP TPGSMLPSVA
     VSPRSCVACF AVLRGTPHTA WVLKMSPVPQ PAPL
//