ID   Q3MS94_HUMAN            Unreviewed;       197 AA.
AC   Q3MS94; E9PHN9;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   02-SEP-2026, entry version 121.
DE   SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4 {ECO:0000313|EMBL:CAJ19684.1};
DE   Flags: Fragment;
GN   Name=BTK kinase deficient isoform 4 {ECO:0000313|EMBL:CAJ19684.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAJ19684.1};
RN   [1] {ECO:0000313|EMBL:CAJ19684.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16141323; DOI=10.1073/pnas.0505196102;
RA   Feldhahn N., Rio P., Ndikung B.B.S., Liedtke S., Sprangers M., Klein F.,
RA   Wernet P., Jumaa H., Hofmann W.K., Hanenberg H., Rowley J.D., Mueschen M.;
RT   "Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia
RT   cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13266-13271(2005).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM051278; CAJ19684.1; -; mRNA.
DR   AlphaFoldDB; Q3MS94; -.
DR   SMR; Q3MS94; -.
DR   OpenTargets; ENSG00000010671; -.
DR   GeneTree; ENSGT00940000158469; -.
DR   OrthoDB; 4062651at2759; -.
DR   ChiTaRS; BTK; human.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-ARBA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR   FunFam; 3.30.200.20:FF:000053; Tyrosine-protein kinase; 1.
DR   Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR050198; Non-receptor_tyrosine_kinases.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAJ19684.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT   DOMAIN          1..48
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          73..197
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         101
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAJ19684.1"
SQ   SEQUENCE   197 AA;  22813 MW;  936CCD7D331A1A2E CRC64;
     VIRHYVVCST PQSQYYLAEK HLFSTIPELI NYHQHNSAGL ISRLKYPVSQ QNKNAPSTAG
     LGYGSWEIDP KDLTFLKELG TGQFGVVKYG KWRGQYDVAI KMIKEGSMSE DEFIEEAKVM
     MNLSHEKLVQ LYGVCTKQRP IFIITEYMAN GCLLNYLREM RHRFQTQQLL EMCKDVCEAM
     EYLESKQFLH RDLVCPG
//