ID   Q3MF34_TRIV2            Unreviewed;       414 AA.
AC   Q3MF34;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   02-SEP-2026, entry version 91.
DE   RecName: Full=Dolichol-phosphate mannosyltransferase {ECO:0000256|ARBA:ARBA00074878};
DE            EC=2.4.1.83 {ECO:0000256|ARBA:ARBA00012704};
DE   AltName: Full=Dolichol-phosphate mannose synthase {ECO:0000256|ARBA:ARBA00082614};
DE   AltName: Full=Dolichyl-phosphate beta-D-mannosyltransferase {ECO:0000256|ARBA:ARBA00082336};
DE   AltName: Full=Mannose-P-dolichol synthase {ECO:0000256|ARBA:ARBA00083744};
GN   OrderedLocusNames=Ava_0778 {ECO:0000313|EMBL:ABA20402.1};
OS   Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis).
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Nostocales;
OC   Nostocaceae; Trichormus.
OX   NCBI_TaxID=240292 {ECO:0000313|EMBL:ABA20402.1, ECO:0000313|Proteomes:UP000002533};
RN   [1] {ECO:0000313|Proteomes:UP000002533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29413 / PCC 7937 {ECO:0000313|Proteomes:UP000002533};
RX   PubMed=25197444; DOI=10.4056/sigs.3899418;
RA   Thiel T., Pratte B.S., Zhong J., Goodwin L., Copeland A., Lucas S., Han C.,
RA   Pitluck S., Land M.L., Kyrpides N.C., Woyke T.;
RT   "Complete genome sequence of Anabaena variabilis ATCC 29413.";
RL   Stand. Genomic Sci. 9:562-573(2014).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC       {ECO:0000256|ARBA:ARBA00006739}.
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DR   EMBL; CP000117; ABA20402.1; -; Genomic_DNA.
DR   RefSeq; WP_011317636.1; NC_007413.1.
DR   AlphaFoldDB; Q3MF34; -.
DR   STRING; 240292.Ava_0778; -.
DR   GeneID; 58723441; -.
DR   KEGG; ava:Ava_0778; -.
DR   eggNOG; COG0463; Bacteria.
DR   eggNOG; COG2246; Bacteria.
DR   HOGENOM; CLU_039727_0_0_3; -.
DR   Proteomes; UP000002533; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035269; P:protein O-linked glycosylation via mannose; IEA:TreeGrafter.
DR   CDD; cd06442; DPM1_like; 1.
DR   FunFam; 3.90.550.10:FF:000119; Dolichol-phosphate mannosyltransferase subunit 1; 1.
DR   Gene3D; 3.90.550.10; Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A; 1.
DR   InterPro; IPR039528; DPM1-like.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR007267; GtrA_DPMS_TM.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43398; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1; 1.
DR   PANTHER; PTHR43398:SF1; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1; 1.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   Pfam; PF04138; GtrA_DPMS_TM; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000313|EMBL:ABA20402.1}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002533};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABA20402.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        283..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          37..204
FT                   /note="Glycosyltransferase 2-like"
FT                   /evidence="ECO:0000259|Pfam:PF00535"
FT   DOMAIN          285..407
FT                   /note="GtrA/DPMS transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04138"
SQ   SEQUENCE   414 AA;  46642 MW;  3F97BF724536F74C CRC64;
     MKINIANELL TVPTGLLQVS DVPPNSVGTG HRDIFFSLII PTYKERDNIE NVVKILSQTL
     DEFIPGDYEL IVVDDDSPDM TWEVAHSLTE EYPQLRVMRR QQERGLSSAV VRGWQVARGS
     VLGVIDGDLQ HPPEVLTQLL TKITQGADLA LASRHVDGGG VSSWSVVRRF LSRGAQVLGL
     MLLPGVLGRV SDPMSGYFMV RRSSVARATL NPVGYKILLE VIGRGNVKNI AEVGYVFCER
     QQGESKVTWK QYIDYIHHLV RLRLSTGRVG RVQKKMNFPI DRFLRFALVG LSGVFVDMVL
     LYLLSDPSTL ALPLTRSKII AGEIAIFNNF LWNDAWTFAD VTMKQQEWHQ RLKRFAKFNV
     ICLAGLVLNV LVLNLVFNFL IPNRYVANLV AIAVATIWNF WVNLKLSWRV TDVK
//