ID   PCYA_SYNS9              Reviewed;         246 AA.
AC   Q3AXI3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   10-JUN-2026, entry version 102.
DE   RecName: Full=Phycocyanobilin:ferredoxin oxidoreductase {ECO:0000255|HAMAP-Rule:MF_00618};
DE            EC=1.3.7.5 {ECO:0000255|HAMAP-Rule:MF_00618};
DE   AltName: Full=Ferredoxin-dependent bilin reductase {ECO:0000255|HAMAP-Rule:MF_00618};
DE            Short=FDBR {ECO:0000255|HAMAP-Rule:MF_00618};
GN   Name=pcyA {ECO:0000255|HAMAP-Rule:MF_00618};
GN   OrderedLocusNames=Syncc9902_1253;
OS   Synechococcus sp. (strain CC9902).
OC   Bacteria; Bacillati; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC   Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=316279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC9902;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F.,
RA   Land M., Kyrpides N., Ivanova N., Richardson P.;
RT   "Complete sequence of Synechococcus sp. CC9902.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the four-electron reduction of biliverdin IX-alpha
CC       (2-electron reduction at both the A and D rings); the reaction proceeds
CC       via an isolatable 2-electron intermediate, 18(1),18(2)-
CC       dihydrobiliverdin. {ECO:0000255|HAMAP-Rule:MF_00618}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R,3Z)-phycocyanobilin + 4 oxidized [2Fe-2S]-[ferredoxin] =
CC         biliverdin IXalpha + 4 reduced [2Fe-2S]-[ferredoxin] + 4 H(+);
CC         Xref=Rhea:RHEA:15309, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC         ChEBI:CHEBI:57437, ChEBI:CHEBI:57991; EC=1.3.7.5;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00618};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00618}.
CC   -!- SIMILARITY: Belongs to the HY2 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00618}.
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DR   EMBL; CP000097; ABB26217.1; -; Genomic_DNA.
DR   RefSeq; WP_011360042.1; NC_007513.1.
DR   AlphaFoldDB; Q3AXI3; -.
DR   SMR; Q3AXI3; -.
DR   STRING; 316279.Syncc9902_1253; -.
DR   KEGG; sye:Syncc9902_1253; -.
DR   eggNOG; ENOG502Z7RN; Bacteria.
DR   HOGENOM; CLU_074224_0_0_3; -.
DR   OrthoDB; 581340at2; -.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:InterPro.
DR   GO; GO:0050620; F:phycocyanobilin:ferredoxin oxidoreductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0010024; P:phytochromobilin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.1500.20; -; 1.
DR   HAMAP; MF_00618; Ferredoxin_bilin_red; 1.
DR   InterPro; IPR009249; Ferredoxin-dep_bilin_Rdtase.
DR   InterPro; IPR022870; Ferredoxin_bilin_OxRdtase.
DR   NCBIfam; NF002760; PRK02816.1; 1.
DR   PANTHER; PTHR34557; PHYTOCHROMOBILIN:FERREDOXIN OXIDOREDUCTASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR34557:SF1; PHYTOCHROMOBILIN:FERREDOXIN OXIDOREDUCTASE, CHLOROPLASTIC; 1.
DR   Pfam; PF05996; Fe_bilin_red; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..246
FT                   /note="Phycocyanobilin:ferredoxin oxidoreductase"
FT                   /id="PRO_1000061377"
FT   ACT_SITE        72
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   ACT_SITE        84
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   ACT_SITE        101
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   BINDING         84
FT                   /ligand="biliverdin IXalpha"
FT                   /ligand_id="ChEBI:CHEBI:57991"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   BINDING         101
FT                   /ligand="biliverdin IXalpha"
FT                   /ligand_id="ChEBI:CHEBI:57991"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   BINDING         110
FT                   /ligand="biliverdin IXalpha"
FT                   /ligand_id="ChEBI:CHEBI:57991"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   BINDING         143
FT                   /ligand="biliverdin IXalpha"
FT                   /ligand_id="ChEBI:CHEBI:57991"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
FT   BINDING         217
FT                   /ligand="biliverdin IXalpha"
FT                   /ligand_id="ChEBI:CHEBI:57991"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00618"
SQ   SEQUENCE   246 AA;  27464 MW;  A430D1EB983B5BAE CRC64;
     MQPQSKDPCQ ELHPLVSTLA ASIRSSWQKL PELAPLCTAD DLKAIHGELD GETLFIGNEL
     YQCRGFRKIH LEIARLGNGL QILHCVWFPD PQYDLPIFGA DIVAGPAGIS AAIVDLSPTS
     GELPDPVFKG LEAIERPAFR QVRDLPGWGT IFSSKVCFIR PDGADEEALF NQVVIDYLEV
     LSDCASRANP ESPTTVSTIN RYEGQLNYCL QQKRNDKTRR VLEKAFDPEW ADRYIELLLF
     DNPPTP
//