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<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-11-04" version="110" xmlns="http://uniprot.org/uniprot">
  <accession>Q3AJT9</accession>
  <name>ARGC_SYNSC</name>
  <protein>
    <recommendedName>
      <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
      <shortName evidence="1">AGPR</shortName>
      <ecNumber evidence="1">1.2.1.38</ecNumber>
    </recommendedName>
    <alternativeName>
      <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
      <shortName evidence="1">NAGSA dehydrogenase</shortName>
    </alternativeName>
  </protein>
  <gene>
    <name evidence="1" type="primary">argC</name>
    <name type="ordered locus">Syncc9605_1389</name>
  </gene>
  <organism>
    <name type="scientific">Synechococcus sp. (strain CC9605)</name>
    <dbReference type="NCBI Taxonomy" id="110662"/>
    <lineage>
      <taxon>Bacteria</taxon>
      <taxon>Bacillati</taxon>
      <taxon>Cyanobacteriota</taxon>
      <taxon>Cyanophyceae</taxon>
      <taxon>Synechococcales</taxon>
      <taxon>Synechococcaceae</taxon>
      <taxon>Synechococcus</taxon>
    </lineage>
  </organism>
  <reference key="1">
    <citation type="submission" date="2005-07" db="EMBL/GenBank/DDBJ databases">
      <title>Complete sequence of Synechococcus sp. CC9605.</title>
      <authorList>
        <consortium name="US DOE Joint Genome Institute"/>
        <person name="Copeland A."/>
        <person name="Lucas S."/>
        <person name="Lapidus A."/>
        <person name="Barry K."/>
        <person name="Detter J.C."/>
        <person name="Glavina T."/>
        <person name="Hammon N."/>
        <person name="Israni S."/>
        <person name="Pitluck S."/>
        <person name="Schmutz J."/>
        <person name="Martinez M."/>
        <person name="Larimer F."/>
        <person name="Land M."/>
        <person name="Kyrpides N."/>
        <person name="Ivanova N."/>
        <person name="Richardson P."/>
      </authorList>
    </citation>
    <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    <source>
      <strain>CC9605</strain>
    </source>
  </reference>
  <comment type="function">
    <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
  </comment>
  <comment type="catalytic activity">
    <reaction evidence="1">
      <text>N-acetyl-L-glutamate 5-semialdehyde + phosphate + NADP(+) = N-acetyl-L-glutamyl 5-phosphate + NADPH + H(+)</text>
      <dbReference type="Rhea" id="RHEA:21588"/>
      <dbReference type="ChEBI" id="CHEBI:15378"/>
      <dbReference type="ChEBI" id="CHEBI:29123"/>
      <dbReference type="ChEBI" id="CHEBI:43474"/>
      <dbReference type="ChEBI" id="CHEBI:57783"/>
      <dbReference type="ChEBI" id="CHEBI:57936"/>
      <dbReference type="ChEBI" id="CHEBI:58349"/>
      <dbReference type="EC" id="1.2.1.38"/>
    </reaction>
  </comment>
  <comment type="pathway">
    <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
  </comment>
  <comment type="subcellular location">
    <subcellularLocation>
      <location evidence="1">Cytoplasm</location>
    </subcellularLocation>
  </comment>
  <comment type="similarity">
    <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
  </comment>
  <dbReference type="EC" id="1.2.1.38" evidence="1"/>
  <dbReference type="EMBL" id="CP000110">
    <property type="protein sequence ID" value="ABB35143.1"/>
    <property type="molecule type" value="Genomic_DNA"/>
  </dbReference>
  <dbReference type="RefSeq" id="WP_011364360.1">
    <property type="nucleotide sequence ID" value="NC_007516.1"/>
  </dbReference>
  <dbReference type="AlphaFoldDB" id="Q3AJT9"/>
  <dbReference type="SMR" id="Q3AJT9"/>
  <dbReference type="STRING" id="110662.Syncc9605_1389"/>
  <dbReference type="KEGG" id="syd:Syncc9605_1389"/>
  <dbReference type="eggNOG" id="COG0002">
    <property type="taxonomic scope" value="Bacteria"/>
  </dbReference>
  <dbReference type="HOGENOM" id="CLU_006384_0_1_3"/>
  <dbReference type="OMA" id="AACHRHQ"/>
  <dbReference type="OrthoDB" id="9801289at2"/>
  <dbReference type="UniPathway" id="UPA00068">
    <property type="reaction ID" value="UER00108"/>
  </dbReference>
  <dbReference type="GO" id="GO:0005737">
    <property type="term" value="C:cytoplasm"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-SubCell"/>
  </dbReference>
  <dbReference type="GO" id="GO:0003942">
    <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="GO" id="GO:0051287">
    <property type="term" value="F:NAD binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0070401">
    <property type="term" value="F:NADP+ binding"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="InterPro"/>
  </dbReference>
  <dbReference type="GO" id="GO:0006526">
    <property type="term" value="P:L-arginine biosynthetic process"/>
    <property type="evidence" value="ECO:0000501"/>
    <property type="project" value="UniProtKB-UniRule"/>
  </dbReference>
  <dbReference type="CDD" id="cd23934">
    <property type="entry name" value="AGPR_1_C"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="CDD" id="cd17895">
    <property type="entry name" value="AGPR_1_N"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="FunFam" id="3.30.360.10:FF:000014">
    <property type="entry name" value="N-acetyl-gamma-glutamyl-phosphate reductase"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.30.360.10">
    <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Gene3D" id="3.40.50.720">
    <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="HAMAP" id="MF_00150">
    <property type="entry name" value="ArgC_type1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR050085">
    <property type="entry name" value="AGPR"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR023013">
    <property type="entry name" value="AGPR_AS"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR058924">
    <property type="entry name" value="AGPR_dimerisation_dom"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR000706">
    <property type="entry name" value="AGPR_type-1"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR036291">
    <property type="entry name" value="NAD(P)-bd_dom_sf"/>
  </dbReference>
  <dbReference type="InterPro" id="IPR000534">
    <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
  </dbReference>
  <dbReference type="NCBIfam" id="TIGR01850">
    <property type="entry name" value="argC"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR32338:SF10">
    <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PANTHER" id="PTHR32338">
    <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF01118">
    <property type="entry name" value="Semialdhyde_dh"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="Pfam" id="PF22698">
    <property type="entry name" value="Semialdhyde_dhC_1"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SMART" id="SM00859">
    <property type="entry name" value="Semialdhyde_dh"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF55347">
    <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="SUPFAM" id="SSF51735">
    <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
    <property type="match status" value="1"/>
  </dbReference>
  <dbReference type="PROSITE" id="PS01224">
    <property type="entry name" value="ARGC"/>
    <property type="match status" value="1"/>
  </dbReference>
  <proteinExistence type="inferred from homology"/>
  <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
  <keyword id="KW-0055">Arginine biosynthesis</keyword>
  <keyword id="KW-0963">Cytoplasm</keyword>
  <keyword id="KW-0521">NADP</keyword>
  <keyword id="KW-0560">Oxidoreductase</keyword>
  <feature type="chain" id="PRO_1000011074" description="N-acetyl-gamma-glutamyl-phosphate reductase">
    <location>
      <begin position="1"/>
      <end position="357"/>
    </location>
  </feature>
  <feature type="active site" evidence="1">
    <location>
      <position position="160"/>
    </location>
  </feature>
  <evidence type="ECO:0000255" key="1">
    <source>
      <dbReference type="HAMAP-Rule" id="MF_00150"/>
    </source>
  </evidence>
  <sequence length="357" mass="38053" checksum="5800D4B1BC87BD19" modified="2005-11-22" version="1">MATVKGGRVAVIGASGYGGLQTIRLLQGHPGLSVSFLGGERSAGQRWSSVCSFLPLPDDPKVESADPDRIAACSDFAVLSLPNGLACQLAPQLLERGVRVVDLSADFRYRSLEQWLQVYAKEAGSLNRQDAELCSSAVYGLPEWNGPAIADAKLVAAPGCFPTASLMPLLPFLKQGLIETSGIIIDAKTGTSGGGRVPKEAMLLAEASESIAPYGVIGHRHTSEIEQMAMEVAGQDIRLQFTPHLVPMVRGLLSTVYARLRDPGLTAEDCTTVLEAIYRHHPCVQVLPVGTYPATKWARHTNRALLSVQVDTRTGQLVLMSAIDNLIKGQAGQGVQCINLMAGLAPETGLPLQSFYP</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>