ID   Q3AAP6_CARHZ            Unreviewed;       507 AA.
AC   Q3AAP6;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   28-JAN-2026, entry version 87.
DE   SubName: Full=HDIG domain protein {ECO:0000313|EMBL:ABB14681.1};
GN   OrderedLocusNames=CHY_1969 {ECO:0000313|EMBL:ABB14681.1};
OS   Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 /
OS   Z-2901).
OC   Bacteria; Bacillati; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Carboxydothermus.
OX   NCBI_TaxID=246194 {ECO:0000313|EMBL:ABB14681.1, ECO:0000313|Proteomes:UP000002706};
RN   [1] {ECO:0000313|EMBL:ABB14681.1, ECO:0000313|Proteomes:UP000002706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-161 / DSM 6008 / Z-2901
RC   {ECO:0000313|Proteomes:UP000002706};
RX   PubMed=16311624; DOI=10.1371/journal.pgen.0010065;
RA   Wu M., Ren Q., Durkin A.S., Daugherty S.C., Brinkac L.M., Dodson R.J.,
RA   Madupu R., Sullivan S.A., Kolonay J.F., Haft D.H., Nelson W.C.,
RA   Tallon L.J., Jones K.M., Ulrich L.E., Gonzalez J.M., Zhulin I.B.,
RA   Robb F.T., Eisen J.A.;
RT   "Life in hot carbon monoxide: the complete genome sequence of
RT   Carboxydothermus hydrogenoformans Z-2901.";
RL   PLoS Genet. 1:563-574(2005).
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DR   EMBL; CP000141; ABB14681.1; -; Genomic_DNA.
DR   RefSeq; WP_011344861.1; NC_007503.1.
DR   AlphaFoldDB; Q3AAP6; -.
DR   STRING; 246194.CHY_1969; -.
DR   KEGG; chy:CHY_1969; -.
DR   eggNOG; COG2206; Bacteria.
DR   HOGENOM; CLU_000445_92_13_9; -.
DR   InParanoid; Q3AAP6; -.
DR   OrthoDB; 10822at2; -.
DR   Proteomes; UP000002706; Chromosome.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR037522; HD_GYP_dom.
DR   InterPro; IPR006675; HDIG_dom.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR   PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR   Pfam; PF13492; GAF_3; 1.
DR   Pfam; PF13487; HD_5; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   PROSITE; PS51831; HD; 1.
DR   PROSITE; PS51832; HD_GYP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002706};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        35..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        135..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          319..507
FT                   /note="HD-GYP"
FT                   /evidence="ECO:0000259|PROSITE:PS51832"
FT   DOMAIN          341..463
FT                   /note="HD"
FT                   /evidence="ECO:0000259|PROSITE:PS51831"
SQ   SEQUENCE   507 AA;  57748 MW;  74AE25502428235B CRC64;
     MVDQIIGDFH RLRFLALVGA LLFFLFNSEP INKKAFLIFL IAVIYSIVLY AYLLKKPEKR
     DFGYKVSFWL DCLLLTALIY YTGLGHSLFY FGYVLLVAIH TFYYGPQFGL LTATVSTAMY
     FIVCYLDPEV KWFDFLFKAG FLFVMVIGVA VVYWENYRLK KLYLEEISKL RDLTAKTQKI
     AQIQDLKELA DFGLKMAVNI SGALAGIVWV LDERRKNLHP IAVFGIEKKD LPWVLPAEIL
     SSLISAENCE AIITGESFTK LTFEKNYQKV YTVCLAGKEQ RIGFLNLYGN GEFKNLDYLT
     IFCGYLASQM SIVRLYEQSK ELCFSITQAL VMAIEAKDSY TAGHSLRVTA IAEKIGKKLG
     FSLERLEKLR KAALLHDIGK IGISEKILNK PGKLLPEEYR EIQNHPGIGV EIIKPIEQMQ
     DIIEIIYHHH EWYDGTGYPA RLKGEEIPLE ARVLAVADAF EAMTSDRSYR KALTKEEAIA
     EIIKQKGKQF DPQVVEAFLE VVKEVGG
//