ID   POR_CHLRE               Reviewed;         397 AA.
AC   Q39617;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-SEP-2026, entry version 141.
DE   RecName: Full=Protochlorophyllide reductase, chloroplastic;
DE            Short=PCR;
DE            EC=1.3.1.33;
DE   AltName: Full=NADPH-protochlorophyllide oxidoreductase;
DE            Short=POR;
DE   Flags: Precursor;
GN   Name=PORA; Synonyms=LPCR-1;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=137c / CC-125;
RX   PubMed=8616232; DOI=10.1007/bf00017800;
RA   Li J., Timko M.P.;
RT   "The pc-1 phenotype of Chlamydomonas reinhardtii results from a deletion
RT   mutation in the nuclear gene for NADPH:protochlorophyllide
RT   oxidoreductase.";
RL   Plant Mol. Biol. 30:15-37(1996).
CC   -!- FUNCTION: Phototransformation of protochlorophyllide (Pchlide) to
CC       chlorophyllide (Chlide).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chlorophyllide a + NADP(+) = protochlorophyllide a + NADPH +
CC         H(+); Xref=Rhea:RHEA:11132, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349, ChEBI:CHEBI:83348, ChEBI:CHEBI:83350; EC=1.3.1.33;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC       biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. POR subfamily. {ECO:0000305}.
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DR   EMBL; U36752; AAB04951.1; -; Genomic_DNA.
DR   PIR; S71468; S71468.
DR   RefSeq; XP_001689464.1; XM_001689412.2.
DR   AlphaFoldDB; Q39617; -.
DR   SMR; Q39617; -.
DR   ProMEX; Q39617; -.
DR   EnsemblPlants; PNW88126; PNW88126; CHLRE_01g015350v5.
DR   Gramene; PNW88126; PNW88126; CHLRE_01g015350v5.
DR   KEGG; cre:CHLRE_01g015350v5; -.
DR   eggNOG; KOG1208; Eukaryota.
DR   HOGENOM; CLU_010194_44_3_1; -.
DR   OMA; SKVACMM; -.
DR   OrthoDB; 191139at2759; -.
DR   BRENDA; 1.3.1.33; 1318.
DR   UniPathway; UPA00668; -.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0016630; F:protochlorophyllide reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd09810; LPOR_like_SDR_c_like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR005979; Prochl_reduct.
DR   InterPro; IPR002347; SDR_fam.
DR   NCBIfam; TIGR01289; LPOR; 1.
DR   PANTHER; PTHR44419:SF19; PROTOCHLOROPHYLLIDE REDUCTASE A, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR44419; PROTOCHLOROPHYLLIDE REDUCTASE C, CHLOROPLASTIC; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Chloroplast; NADP; Oxidoreductase;
KW   Photosynthesis; Plastid; Transit peptide.
FT   TRANSIT         1..57
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           58..397
FT                   /note="Protochlorophyllide reductase, chloroplastic"
FT                   /id="PRO_0000023290"
SQ   SEQUENCE   397 AA;  41871 MW;  4CEF08F15545754D CRC64;
     MALTMSAKSV SARAQVSSKA QAAPAVAVSG RTSSRVMPAP ALAARSSVAR TPLVVCAATA
     TAPSPSLADK FKPNAIARVP ATQQKQTAII TGASSGLGLN AAKALAATGE WHVVMACRDF
     LKAEQAAKKV GMPAGSYSIL HLDLSSLESV RQFVQNFKAS GRRLDALVCN AAVYLPTAKE
     PRFTADGFEL SVGTNHLGHF LLTNLLLDDL KNAPNKQPRC IIVGSITGNT NTLAGNVPPK
     ANLGDLSGLA AGVPAANPMM DGQEFNGAKA YKDSKVACMM TVRQMHQRFH DATGITFASL
     YPGCIAETGL FREHVPLFKT LFPPFQKYIT KGYVSEEEAG RRLAAVISDP KLNKSGAYWS
     WSSTTGSFDN QVSEEVADDS KASKLWDISA KLVGLSA
//