ID   Q38CL9_TRYB2            Unreviewed;       250 AA.
AC   Q38CL9;
DT   22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2005, sequence version 1.
DT   02-SEP-2026, entry version 101.
DE   RecName: Full=40S ribosomal protein S6 {ECO:0000256|PIRNR:PIRNR002129};
GN   ORFNames=Tb10.100.0080 {ECO:0000313|EMBL:EAN77451.1};
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN77451.1, ECO:0000313|Proteomes:UP000008524};
RN   [1] {ECO:0000313|EMBL:EAN77451.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77451.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020724; DOI=10.1126/science.1112181;
RA   El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA   Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA   Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA   Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA   Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA   Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA   Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA   Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA   Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT   "Comparative genomics of trypanosomatid parasitic protozoa.";
RL   Science 309:404-409(2005).
RN   [2] {ECO:0000313|EMBL:EAN77451.1, ECO:0000313|Proteomes:UP000008524}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN77451.1,
RC   ECO:0000313|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
RN   [3] {ECO:0007829|PDB:4V8M}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.57 ANGSTROMS).
RX   PubMed=23395961; DOI=10.1038/nature11872;
RA   Hashem Y., des Georges A., Fu J., Buss S.N., Jossinet F., Jobe A.,
RA   Zhang Q., Liao H.Y., Grassucci R.A., Bajaj C., Westhof E.,
RA   Madison-Antenucci S., Frank J.;
RT   "High-resolution cryo-electron microscopy structure of the Trypanosoma
RT   brucei ribosome.";
RL   Nature 494:385-389(2013).
RN   [4] {ECO:0007829|PDB:8OVA, ECO:0007829|PDB:8OVE}
RP   STRUCTURE BY ELECTRON MICROSCOPY (2.47 ANGSTROMS) IN COMPLEX WITH MG(2+).
RX   PubMed=37985661; DOI=10.1038/s41467-023-43263-6;
RA   Rajan K.S., Madmoni H., Bashan A., Taoka M., Aryal S., Nobe Y., Doniger T.,
RA   Galili Kostin B., Blumberg A., Cohen-Chalamish S., Schwartz S., Rivalta A.,
RA   Zimmerman E., Unger R., Isobe T., Yonath A., Michaeli S.;
RT   "A single pseudouridine on rRNA regulates ribosome structure and function
RT   in the mammalian parasite Trypanosoma brucei.";
RL   Nat. Commun. 14:7462-7462(2023).
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS6 family.
CC       {ECO:0000256|ARBA:ARBA00009312, ECO:0000256|PIRNR:PIRNR002129}.
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DR   EMBL; CM000208; EAN77451.1; -; Genomic_DNA.
DR   RefSeq; XP_822279.1; XM_817186.1.
DR   PDB; 4V8M; EM; 5.57 A; A3=1-250.
DR   PDB; 8OVA; EM; 2.47 A; A3=1-250.
DR   PDB; 8OVE; EM; 2.60 A; A3=1-250.
DR   AlphaFoldDB; Q38CL9; -.
DR   EMDB; EMD-17208; -.
DR   EMDB; EMD-17212; -.
DR   FunCoup; Q38CL9; 512.
DR   IntAct; Q38CL9; 1.
DR   STRING; 185431.Q38CL9; -.
DR   PaxDb; 185431-Q38CL9; -.
DR   GeneID; 3661495; -.
DR   KEGG; tbr:Tb10.100.0080; -.
DR   VEuPathDB; TriTrypDB:Tb927.10.190; -.
DR   eggNOG; KOG1646; Eukaryota.
DR   InParanoid; Q38CL9; -.
DR   OMA; KPRYKAP; -.
DR   OrthoDB; 10260596at2759; -.
DR   Proteomes; UP000008524; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; HTP:Others.
DR   GO; GO:0005730; C:nucleolus; HTP:Others.
DR   GO; GO:0005840; C:ribosome; ISM:GeneDB.
DR   GO; GO:0003729; F:mRNA binding; IDA:GeneDB.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISM:GeneDB.
DR   GO; GO:0001558; P:regulation of cell growth; ISA:GeneDB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISA:GeneDB.
DR   GO; GO:0006412; P:translation; ISM:GeneDB.
DR   FunFam; 1.20.5.2650:FF:000004; 40S ribosomal protein S6; 1.
DR   Gene3D; 1.20.5.2650; -; 1.
DR   InterPro; IPR001377; Ribosomal_eS6.
DR   InterPro; IPR014401; Ribosomal_eS6-like.
DR   InterPro; IPR018282; Ribosomal_eS6_CS.
DR   PANTHER; PTHR11502; 40S RIBOSOMAL PROTEIN S6; 1.
DR   Pfam; PF01092; Ribosomal_S6e; 1.
DR   PIRSF; PIRSF002129; Ribosom_S6_euk; 1.
DR   SMART; SM01405; Ribosomal_S6e; 1.
DR   PROSITE; PS00578; RIBOSOMAL_S6E; 1.
DR   PDBsum; 4V8M; -.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4V8M, ECO:0007829|PDB:8OVA};
KW   Metal-binding {ECO:0007829|PDB:8OVE};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|PIRNR:PIRNR002129};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW   ECO:0000256|PIRNR:PIRNR002129}.
FT   REGION          219..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..234
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..250
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         180
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0007829|PDB:8OVE"
SQ   SEQUENCE   250 AA;  28440 MW;  0E8D0D3411080D38 CRC64;
     MKLNVAYPRN GTVKQVEVTD EVLRRVNLGD YRLGNEVDGA IFGEAFRGYT FKLRGGSDKE
     GFPMVQGVMA PSRVSLLVKR GAVGFNTFRG YQGERRRKSL RGCILGSDIA VLNVTVEKVG
     EQPIEGVTDV SVPRRLGPKR ANKIRKLFNL GRTDDVRKYV IRRKVTKEGK KDRFKAPKIQ
     RLITSTIRAR RAKKVRVAID KVRKSAAERR EYLRLVGARR RAARQRKAAR HHSSRVNAQR
     KEVDAFKARK
//