ID   Q2S151_SALRD            Unreviewed;       327 AA.
AC   Q2S151;
DT   24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT   24-JAN-2006, sequence version 1.
DT   04-NOV-2026, entry version 114.
DE   SubName: Full=Pyruvate dehydrogenase E1 component, beta subunit {ECO:0000313|EMBL:ABC43655.1};
DE            EC=1.2.4.1 {ECO:0000313|EMBL:ABC43655.1};
GN   OrderedLocusNames=SRU_1970 {ECO:0000313|EMBL:ABC43655.1};
OS   Salinibacter ruber (strain DSM 13855 / M31).
OC   Bacteria; Pseudomonadati; Rhodothermota; Rhodothermia; Rhodothermales;
OC   Salinibacteraceae; Salinibacter.
OX   NCBI_TaxID=309807 {ECO:0000313|EMBL:ABC43655.1, ECO:0000313|Proteomes:UP000008674};
RN   [1] {ECO:0000313|EMBL:ABC43655.1, ECO:0000313|Proteomes:UP000008674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 13855 / CECT 5946 / M31
RC   {ECO:0000313|Proteomes:UP000008674};
RX   PubMed=16330755; DOI=10.1073/pnas.0509073102;
RA   Mongodin E.F., Nelson K.E., Daugherty S., Deboy R.T., Wister J., Khouri H.,
RA   Weidman J., Walsh D.A., Papke R.T., Sanchez Perez G., Sharma A.K.,
RA   Nesbo C.L., MacLeod D., Bapteste E., Doolittle W.F., Charlebois R.L.,
RA   Legault B., Rodriguez-Valera F.;
RT   "The genome of Salinibacter ruber: convergence and gene exchange among
RT   hyperhalophilic bacteria and archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:18147-18152(2005).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000159; ABC43655.1; -; Genomic_DNA.
DR   RefSeq; WP_011404705.1; NC_007677.1.
DR   AlphaFoldDB; Q2S151; -.
DR   STRING; 309807.SRU_1970; -.
DR   EnsemblBacteria; ABC43655; ABC43655; SRU_1970.
DR   KEGG; sru:SRU_1970; -.
DR   PATRIC; fig|309807.25.peg.2044; -.
DR   eggNOG; COG0022; Bacteria.
DR   HOGENOM; CLU_012907_1_1_10; -.
DR   OMA; AAHHSQC; -.
DR   OrthoDB; 9771835at2; -.
DR   Proteomes; UP000008674; Chromosome.
DR   GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR   CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR   FunFam; 3.40.50.920:FF:000001; Pyruvate dehydrogenase E1 beta subunit; 1.
DR   FunFam; 3.40.50.970:FF:000001; Pyruvate dehydrogenase E1 beta subunit; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   NCBIfam; NF006667; PRK09212.1; 1.
DR   NCBIfam; NF008854; PRK11892.1; 1.
DR   PANTHER; PTHR43257; PYRUVATE DEHYDROGENASE E1 COMPONENT BETA SUBUNIT; 1.
DR   PANTHER; PTHR43257:SF2; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ABC43655.1}; Pyruvate {ECO:0000313|EMBL:ABC43655.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008674};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          4..179
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   327 AA;  35869 MW;  71343D44C1D2202D CRC64;
     MATLEFRTAL REAMTEEMER DDDIFLIGEE VAEYDGAYKV SKGMLDHFGS DRVIDSPISE
     LGFAGLGIGA AMNGLRPIVE FMTFNFSFVA FDQVINNAPN MRYMSGGQFD VPIVFRGPNG
     AAGQLGATHS NSTEALYSNI PGLKVVSPSV PDDGKGLLKT AIRDDDPVVF LESELMYGMK
     REVSEESDYT IPIGSARVAR EGDDVTIVAH SKSYHIAMDA AETLEEQGYE AEVIDPRTIK
     PLDIETIVES VVKTNRLVVI DESTPFTSVA SEITHQVQDR AFDYLDAPIL RVTAPDTPAP
     YAPNLMDEYM PGADETVDKC LRVLYAE
//