ID   Q2LSK6_SYNAS            Unreviewed;       648 AA.
AC   Q2LSK6;
DT   21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   21-FEB-2006, sequence version 1.
DT   04-NOV-2026, entry version 99.
DE   SubName: Full=Methyl-accepting chemotaxis protein {ECO:0000313|EMBL:ABC77066.1};
GN   ORFNames=SYN_00971 {ECO:0000313|EMBL:ABC77066.1};
OS   Syntrophus aciditrophicus (strain SB).
OC   Bacteria; Pseudomonadati; Thermodesulfobacteriota; Syntrophia;
OC   Syntrophales; Syntrophaceae; Syntrophus.
OX   NCBI_TaxID=56780 {ECO:0000313|EMBL:ABC77066.1, ECO:0000313|Proteomes:UP000001933};
RN   [1] {ECO:0000313|EMBL:ABC77066.1, ECO:0000313|Proteomes:UP000001933}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB {ECO:0000313|EMBL:ABC77066.1,
RC   ECO:0000313|Proteomes:UP000001933};
RX   PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA   McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA   Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA   Campbell J.W., Gunsalus R.P.;
RT   "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT   of microbial growth.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000252; ABC77066.1; -; Genomic_DNA.
DR   RefSeq; WP_011417095.1; NC_007759.1.
DR   AlphaFoldDB; Q2LSK6; -.
DR   STRING; 56780.SYN_00971; -.
DR   KEGG; sat:SYN_00971; -.
DR   eggNOG; COG0840; Bacteria.
DR   eggNOG; COG4191; Bacteria.
DR   HOGENOM; CLU_000445_107_19_7; -.
DR   InParanoid; Q2LSK6; -.
DR   OMA; AAFHTMQ; -.
DR   OrthoDB; 9765170at2; -.
DR   Proteomes; UP000001933; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd12914; PDC1_DGC_like; 1.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR004090; Chemotax_Me-accpt_rcpt.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   PANTHER; PTHR43531:SF14; METHYL-ACCEPTING CHEMOTAXIS PROTEIN I-RELATED; 1.
DR   PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   PRINTS; PR00260; CHEMTRNSDUCR.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001933};
KW   Transducer {ECO:0000256|PROSITE-ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          334..563
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   REGION          356..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          617..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..377
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  68200 MW;  EFCD1E1774E2E576 CRC64;
     MKKRTLEFKL VAGGILLVLI PLLVTGIFST LRSSKALEST AMGQSEQVAK SVGNMVQLVL
     QEEIKVATHL ASNNTVIEAA AGVAGKGVDG AAVELTRACS TLGMILKKSG TDYEYIVVTD
     SSGKIIADSN GGQLRGMDIS ERDYIKVPKS TGKSHVGEVS KSKATGKPIA PFGAPVYSSS
     GQFLGVVGCV ANIDFISDKI GAVKIGETGY AYVLNKEGVV IAHPKADFIL EKNLAKEEGM
     VEFAQQMLAR KSGTGKYALA GVEKIGGYAP VELTAWSVGV VQDYEELMAP AVSIRNFMML
     ITAAFLALAV VLVLYFARSI SRPIKNAVNT LNDSADQIAS ASMQVSSASQ SLAEGASEQA
     SALEETSSSL EEMSSMTKQN AGNASQADSL MRQANQVVQR ANSSMIHLTD SMQQISKASD
     ETSKIIKTID EVAFQTNLLA LNAAVEAARA GEAGAGFAVV AEEVRNLAMR AADAARNTAS
     LIEGTVKKVK EGSDLVVKTN EAFMEVAESS EKVGGLVSEI AAASNEQAQG IDQVNKAVAE
     MDKVTQQTAA NAEESASASE ELNAQAQQMK NISNDLADIV GAVNSSLASS VNGFQAQAAH
     DSRKGILKKI SALPMSRSIV RSPSPKQKGK EIRPDQIIPL EDDEFKDF
//