ID   Q2J511_FRACC            Unreviewed;      1204 AA.
AC   Q2J511;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   02-SEP-2026, entry version 109.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ABD13631.1};
GN   OrderedLocusNames=Francci3_4285 {ECO:0000313|EMBL:ABD13631.1};
OS   Frankia casuarinae (strain DSM 45818 / CECT 9043 / HFP020203 / CcI3).
OC   Bacteria; Bacillati; Actinomycetota; Actinomycetes; Frankiales;
OC   Frankiaceae; Frankia.
OX   NCBI_TaxID=106370 {ECO:0000313|EMBL:ABD13631.1, ECO:0000313|Proteomes:UP000001937};
RN   [1] {ECO:0000313|EMBL:ABD13631.1, ECO:0000313|Proteomes:UP000001937}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45818 / CECT 9043 / CcI3
RC   {ECO:0000313|Proteomes:UP000001937};
RX   PubMed=17151343; DOI=10.1101/gr.5798407;
RA   Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA   Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA   Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA   Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA   Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA   Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA   Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA   Benson D.R.;
RT   "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT   reflect host range and host plant biogeography.";
RL   Genome Res. 17:7-15(2007).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|PROSITE-ProRule:PRU00099}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00099}.
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DR   EMBL; CP000249; ABD13631.1; -; Genomic_DNA.
DR   RefSeq; WP_011438639.1; NC_007777.1.
DR   AlphaFoldDB; Q2J511; -.
DR   STRING; 106370.Francci3_4285; -.
DR   KEGG; fra:Francci3_4285; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   HOGENOM; CLU_004435_3_1_11; -.
DR   OrthoDB; 5476461at2; -.
DR   PhylomeDB; Q2J511; -.
DR   Proteomes; UP000001937; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-ARBA.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_rpt.
DR   PANTHER; PTHR16305:SF28; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001937};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          51..181
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          815..848
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          1031..1085
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1204 AA;  127518 MW;  12EDEC854C9DBAC4 CRC64;
     MVITAPHTGP LRCPRCSSAA VPGGRFCYHC GLEFTSVESP AVDASERRVV TVLFGDLSDF
     TAWAEDRDPE RVGEMTDRVL AALAHEIDEV GGRVDNLTGD GIMAVFGAPT AHEDDPERAV
     RAAAAMQETV RRLVLTSTGG DDDGRLGLRV GVNTGEVLAG VQAALSYTVI GDTVNTAARL
     SAAATIGTVY AGRETALATR SVATWRELPD LVLKGKREPV PAYELVSLRP SNVARPGLAD
     DAMFLGRDAE LASLTDLFDL VVANQSPEVA LITGEAGIGK TRLAIELACR AERTPGTTVL
     WGRTVRHGDG RGLAPLVDVV RNACGVTDGD SLDRVANRVR RTVAGLAHPH SGARLPPGIA
     DRLLLLLGVP LDRRPAVATA AAPGDPAARA SHIAEAEQRS VDATVDAVAL LLGALASSGP
     ILVMIDDLEW ATSQLSDAMS RLASALSGPI LLVLLDRTGP RLAGLPHIHR IALRPLSLEA
     SSRLLQDHLG GVQLEPRGRA DLLSRVHGNP FFLVELLNLL IDRGMLHQSA ETTNGEWPGW
     VLEGSLTEAT LPAGVQSVLA ARIDDLDPVA KAVLRAAAVL GPRFPAEALP VVDERPAEEV
     TRALRVLTER QLVRPPRATE TRWRFVHPMA RDAAYAGLPK VERARRHATA ARWGVTAMVG
     SSRAVSTFVA NHALRAYDLA ASMNLPITDP AWSSRMSGFH AHVRLAREAL ARDDHRAAAD
     LLANARRLGR GIIDTNEDNV VRVLHAEALV ALRQLDEAER TLRPALRADA PVRRAAAFSV
     LGELRQKQGR AEEAAQCLLT ALESAQQAGD DRAEAAALRR LGMLEYNAGR IDAAEERYRE
     ALAIARQVDD PRGVGWALQH LAWSATTRGD YPRAERTLRE ASAVFDRLED TGGLGWCRGT
     EALVLLLSGQ LTRARKLTRE LIELASSVGE QWGMAVCLTI DAIAAAELGD IATAETHAER
     AAELFTSIGD AWGTMLTLVA RGLAARGTGE SARGAEYLEQ ACAEAAARGH VVVGALARVL
     LGLTWLDAGE VDKAGQAAEI AQADLAQLEL RPHAQLGAKV LVAQIARARG RLDEATELLR
     EALSASEPAT LMFPRRQAYA HLAGILLDAG QPTQALTVAR RAVNVDAEDV RAQVLGYRAL
     GTALVANGDL EGGRAAYLRA LAAATATGAV SEAPQTRRLL ARLPVSGAAD GATITPAGLA
     GTAG
//