ID   Q2IFX2_ANADE            Unreviewed;       526 AA.
AC   Q2IFX2;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   04-NOV-2026, entry version 109.
DE   SubName: Full=Methyl-accepting chemotaxis sensory transducer {ECO:0000313|EMBL:ABC83484.1};
GN   OrderedLocusNames=Adeh_3718 {ECO:0000313|EMBL:ABC83484.1};
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Pseudomonadati; Myxococcota; Myxococcia; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC83484.1};
RN   [1] {ECO:0000313|EMBL:ABC83484.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=2CP-C {ECO:0000313|EMBL:ABC83484.1};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:4K08}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 38-190 IN COMPLEX WITH ZN(2+).
RX   PubMed=23897711; DOI=10.1002/mbo3.112;
RA   Pokkuluri P.R., Dwulit-Smith J., Duke N.E., Wilton R., Mack J.C.,
RA   Bearden J., Rakowski E., Babnigg G., Szurmant H., Joachimiak A.,
RA   Schiffer M.;
RT   "Analysis of periplasmic sensor domains from Anaeromyxobacter dehalogenans
RT   2CP-C: structure of one sensor domain from a histidine kinase and another
RT   from a chemotaxis protein.";
RL   MicrobiologyOpen 2:766-777(2013).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC   -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC       family. {ECO:0000256|ARBA:ARBA00029447}.
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DR   EMBL; CP000251; ABC83484.1; -; Genomic_DNA.
DR   RefSeq; WP_011422766.1; NC_007760.1.
DR   PDB; 4K08; X-ray; 2.00 A; A=38-190.
DR   AlphaFoldDB; Q2IFX2; -.
DR   SMR; Q2IFX2; -.
DR   STRING; 290397.Adeh_3718; -.
DR   KEGG; ade:Adeh_3718; -.
DR   eggNOG; COG0840; Bacteria.
DR   HOGENOM; CLU_000445_107_21_7; -.
DR   OMA; ADAMFPK; -.
DR   OrthoDB; 9791237at2; -.
DR   EvolutionaryTrace; Q2IFX2; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:TreeGrafter.
DR   GO; GO:0006935; P:chemotaxis; IEA:TreeGrafter.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR004089; MCPsignal_dom.
DR   InterPro; IPR033480; sCache_2.
DR   PANTHER; PTHR43531:SF11; METHYL-ACCEPTING CHEMOTAXIS PROTEIN 3; 1.
DR   PANTHER; PTHR43531; PROTEIN ICFG; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF00015; MCPsignal; 1.
DR   Pfam; PF17200; sCache_2; 1.
DR   SMART; SM01049; Cache_2; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00283; MA; 1.
DR   SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR   PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4K08};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0007829|PDB:4K08};
KW   Transducer {ECO:0000256|PROSITE-ProRule:PRU00284};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Zinc {ECO:0007829|PDB:4K08}.
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          214..266
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          271..486
FT                   /note="Methyl-accepting transducer"
FT                   /evidence="ECO:0000259|PROSITE:PS50111"
FT   BINDING         61
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0007829|PDB:4K08"
SQ   SEQUENCE   526 AA;  54835 MW;  46F5717823A14317 CRC64;
     MLHALANLSI STRLRLVLFA GAAGLFLLSW QSVRVLEARM LAERQAKVRA LVEAAHGLVE
     HQGARAARGE ISADEARRAA LEALRALRYD GSEYFWVNDL EPRMVMHPTN PQLDGQDLSG
     YRDPNGKLLF QEFVRTVRAR GSGFVDYLWP KPGSTVPVPK ISFVTQYQPW GWVVGSGLYV
     DDLDAAVRQE ALRVLGTGAL IVAVILGGAA LVARGVRRSL ARAVRAAGAV ASGDLTVRIP
     DAARDEPGRV LDALSGMADR LSAVVGEVRG ASEAIASAAE ETRTVAGALA EASSGQASDV
     ARSSEAVREL VTEIDGAAAE ARATDQLARR AAGDAGEGAQ AVRETALAMR AIAEKIGVVG
     EIAYQTNLLA LNSAIEAARA GVHGRGFAVV ATEVRRLAER SRVAAQEIGE LAGGSVAAAD
     RAAELIARAL PSIGATSERV QRITEAAGRQ HQAARAIGEV LHGLAGASER QAAASEELAG
     SAAALSDNAE ELARTVGWFR VPGGSGEIAP APACVEPPRP AGRQAA
//