ID   Q2FSN1_METHJ            Unreviewed;       252 AA.
AC   Q2FSN1;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   08-OCT-2025, entry version 85.
DE   RecName: Full=Methyl-coenzyme M reductase subunit gamma {ECO:0000256|PIRNR:PIRNR000264};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000264};
GN   OrderedLocusNames=Mhun_2147 {ECO:0000313|EMBL:ABD41853.1};
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Methanobacteriati; Methanobacteriota; Stenosarchaea group;
OC   Methanomicrobia; Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259 {ECO:0000313|EMBL:ABD41853.1, ECO:0000313|Proteomes:UP000001941};
RN   [1] {ECO:0000313|Proteomes:UP000001941}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1
RC   {ECO:0000313|Proteomes:UP000001941};
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=coenzyme B + methyl-coenzyme M = methane + coenzyme M-coenzyme
CC         B heterodisulfide; Xref=Rhea:RHEA:12532, ChEBI:CHEBI:16183,
CC         ChEBI:CHEBI:58286, ChEBI:CHEBI:58411, ChEBI:CHEBI:58596; EC=2.8.4.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00047772};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12533;
CC         Evidence={ECO:0000256|ARBA:ARBA00047772};
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001952};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction; methane
CC       from methyl-coenzyme M: step 1/1. {ECO:0000256|ARBA:ARBA00005149,
CC       ECO:0000256|PIRNR:PIRNR000264}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000264}.
CC   -!- SUBUNIT: MCR is a hexamer of two alpha, two beta, and two gamma chains,
CC       forming a dimer of heterotrimers. {ECO:0000256|ARBA:ARBA00011155}.
CC   -!- SIMILARITY: Belongs to the methyl-coenzyme M reductase gamma subunit
CC       family. {ECO:0000256|ARBA:ARBA00008740}.
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DR   EMBL; CP000254; ABD41853.1; -; Genomic_DNA.
DR   RefSeq; WP_011449111.1; NC_007796.1.
DR   AlphaFoldDB; Q2FSN1; -.
DR   FunCoup; Q2FSN1; 70.
DR   STRING; 323259.Mhun_2147; -.
DR   EnsemblBacteria; ABD41853; ABD41853; Mhun_2147.
DR   GeneID; 3922304; -.
DR   KEGG; mhu:Mhun_2147; -.
DR   eggNOG; arCOG04858; Archaea.
DR   HOGENOM; CLU_1092436_0_0_2; -.
DR   InParanoid; Q2FSN1; -.
DR   OrthoDB; 52520at2157; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.320.20; Methyl-coenzyme M reductase, gamma subunit; 1.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   InterPro; IPR003178; Me_CoM_Rdtase_gsu.
DR   InterPro; IPR036994; Me_CoM_Rdtase_gsu_sf.
DR   NCBIfam; TIGR03259; met_CoM_red_gam; 1.
DR   Pfam; PF02240; MCR_gamma; 1.
DR   PIRSF; PIRSF000264; Meth_CoM_rd_gama; 1.
DR   SUPFAM; SSF55088; Methyl-coenzyme M reductase subunits; 1.
PE   3: Inferred from homology;
KW   Methanogenesis {ECO:0000256|ARBA:ARBA00022994,
KW   ECO:0000256|PIRNR:PIRNR000264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001941};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000264}.
SQ   SEQUENCE   252 AA;  28464 MW;  CFD841EC12AE56CA CRC64;
     MAYTPQYGPG QSIVAENRRK QMNPNVKLEK IRNVTDEDIV LILGHRAPGQ AYPTAHPPLA
     EQGEPDCPIR KIVTPTDGAK AGDRVRYIQF ADSMFNAPSQ PYQRTYTECY RYRGIDPGTL
     SGRQIVECRE RDLEKISADL INTNLFDPAR VGIRGATVHG HSLRLAEDGM MFDMLQRCIL
     EGGTVKYVKD QIGTPLDKKV DVGKPMDDAW LKANTTMFHS LVGTPYRSDA EYIEYIQRIH
     SLRTKYGFMP VE
//